Direct observation of conformational population shifts in crystalline human hemoglobin.
- AnnotationData suggest that in crystal form of Hb containing three protein molecules--Hbalpha(1)beta(2) allosteric effectors (phosphate bezafibrate) induce conformational changes in direction from relaxed-state to tense-state; binding of each effector energetically stabilizes lowest affinity conformer more strongly than intermediate affinity conformer; minor Hb conformers have disproportionate effects on overall O(2) affinity.
- CategoryStructure
- SourceGeneRif: 3039