No Association between Genetic Variants of the COMT and OPRM1 Genes and Pain Perception among Patients Undergoing Total Hip or Knee Arthroplasty for Primary Osteoarthritis.
Influence of genetic variants of opioid-related genes on opioid-induced adverse effects in patients with lung cancer: A STROBE-compliant observational study.
Association between polymorphisms in catechol-O-methyl transferase opioid receptor Mu 1 and serotonin receptor genes with postoperative pain following root canal treatment.
Significant association of mu-opioid receptor 1 haplotype with tobacco smoking in healthy control subjects but not in patients with schizophrenia and alcohol dependence.
Genetic association study of breast cancer patients with post-operative pain fails to find such association between the methylation status of OPRM1 gene to the pain-related phenotype groups.
We found that individuals with OPRM1 AA combined with FAAH Pro/Pro and those carrying COMT met/met together with FAAH Pro/Pro showed significant placebo effects.
The rs1799971 and rs1323040 polymorphisms of the OPRM1 gene and rs2032582 and rs1128503 polymorphisms of the ABCB1 gene are related to the analgesic effect and consumed dose of sufentanil in Chinese Han patients undergoing radical operation of lung cancer.
The OPRM1 A118G AA genotype associated with elevated risk of alcohol-related hospital readmission more readmissions and fewer days until first readmission in male patients only. After normalizing patient 2D:4D against control 2D:4D we found that normalized 2D:4D ratios were lower in male 118G patients than male AA patients suggesting prenatal androgens interact with OPRM1 to influence alcohol dependence risk.
Our results indicate that cathechol-O-methyl-transferase rs4860 and mu-opioid receptor rs1799971 may not contribute to chronic postsurgical pain development after cesarean delivery. The genotype of rs1799971 affects postcesarean analgesic requirement while the rs4680 do not
the present findings on OPRM1 and OPRL1 methylation together with our previous study on OPRK1 and OPRD1 suggest an epigenetic involvement of the opioid system in AD and a potential diagnostic value of opioid receptor methylation for AD.
This study showed that The opioid receptor mu 1 (OPRM1) rs1799971 and catechol-O-methyltransferase (COMT) rs4680 as genetic markers for placebo analgesia.
Subjects with morbid obesity and binge eating disorder (BED) had widespread reduction in OPRM1 binding compared to control subjects. However there was no significant difference in brain OPRM1 binding between subjects with morbid obesity and BED.
The MDR1/CYP3A4/OPRM1 gene polymorphisms influenced the fentanyl consumption and the physiological effects of intravenous analgesia in the Chinese women who received lower segment caesarean section surgeries.
Possession of the OPRM1 minor allele 118G and lower mother-child language style matching were both associated with greater Separation Anxiety Disorder symptoms.
Higher methylation levels within the infants at the -18 (11.4% vs 4.4% P = .0001) -14 (46.1% vs 24.0% P = .002) and +23 (26.3% vs 12.9% P = .008) CpG sites were associated with higher rates of infant pharmacologic treatment. Higher levels of methylation within the mothers at the -169 (R = 0.43 P = .008) -152 (R = 0.40 P = .002) and +84 (R = 0.44 P = .006) sites were associated with longer infant length of stay.
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