Q7Z5B4 · RIC3_HUMAN
- ProteinProtein RIC-3
- GeneRIC3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids369 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | Golgi membrane | |
Cellular Component | intracellular membrane-bounded organelle | |
Cellular Component | neuron projection | |
Cellular Component | neuronal cell body | |
Cellular Component | synapse | |
Molecular Function | acetylcholine receptor binding | |
Molecular Function | protein folding chaperone | |
Biological Process | positive regulation of cytosolic calcium ion concentration | |
Biological Process | positive regulation of protein localization to cell surface | |
Biological Process | protein localization to cell surface | |
Biological Process | protein-containing complex assembly | |
Biological Process | synaptic transmission, cholinergic |
Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameProtein RIC-3
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ7Z5B4
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Isoform 1
Isoform 2
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 29-95 | Lumenal | ||||
Sequence: SRGKRQEPPPTPEGKLGRFPPMMHHHQAPSDGQTPGARFQRSHLAEAFAKAKGSGGGAGGGGSGRGL | ||||||
Transmembrane | 96-116 | Helical | ||||
Sequence: MGQIIPIYGFGIFLYILYILF | ||||||
Topological domain | 117-369 | Cytoplasmic | ||||
Sequence: KLSKGKTTAEDGKCYTAMPGNTHRKITSFELAQLQEKLKETEAAMEKLINRVGPNGESRAQTVTSDQEKRLLHQLREITRVMKEGKFIDRFSPEKEAEEAPYMEDWEGYPEETYPIYDLSDCIKRRQETILVDYPDPKELSAEEIAERMGMIEEEESDHLGWESLPTDPRAQEDNSVTSCDPKPETCSCCFHEDEDPAVLAENAGFSADSYPEQEETTKEEWSQDFKDEGLGISTDKAYTGSMLRKRNPQGLE |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_034943 | 57 | in dbSNP:rs17855498 | |||
Sequence: P → H | ||||||
Natural variant | VAR_062208 | 130 | in dbSNP:rs55990541 | |||
Sequence: C → Y | ||||||
Natural variant | VAR_036391 | 346 | in a colorectal cancer sample; somatic mutation; dbSNP:rs1945152321 | |||
Sequence: G → V |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 500 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, modified residue, cross-link.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-28 | |||||
Sequence: MAYSTVQRVALASGLVLALSLLLPKAFL | ||||||
Chain | PRO_0000302731 | 29-369 | Protein RIC-3 | |||
Sequence: SRGKRQEPPPTPEGKLGRFPPMMHHHQAPSDGQTPGARFQRSHLAEAFAKAKGSGGGAGGGGSGRGLMGQIIPIYGFGIFLYILYILFKLSKGKTTAEDGKCYTAMPGNTHRKITSFELAQLQEKLKETEAAMEKLINRVGPNGESRAQTVTSDQEKRLLHQLREITRVMKEGKFIDRFSPEKEAEEAPYMEDWEGYPEETYPIYDLSDCIKRRQETILVDYPDPKELSAEEIAERMGMIEEEESDHLGWESLPTDPRAQEDNSVTSCDPKPETCSCCFHEDEDPAVLAENAGFSADSYPEQEETTKEEWSQDFKDEGLGISTDKAYTGSMLRKRNPQGLE | ||||||
Modified residue | 202 | N6-acetyllysine; alternate | ||||
Sequence: K | ||||||
Cross-link | 202 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate | ||||
Sequence: K |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Gene expression databases
Organism-specific databases
Interaction
Subunit
Binary interactions
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, coiled coil, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 30-67 | Disordered | ||||
Sequence: RGKRQEPPPTPEGKLGRFPPMMHHHQAPSDGQTPGARF | ||||||
Coiled coil | 140-169 | |||||
Sequence: RKITSFELAQLQEKLKETEAAMEKLINRVG | ||||||
Region | 272-295 | Disordered | ||||
Sequence: ESDHLGWESLPTDPRAQEDNSVTS | ||||||
Region | 316-369 | Disordered | ||||
Sequence: LAENAGFSADSYPEQEETTKEEWSQDFKDEGLGISTDKAYTGSMLRKRNPQGLE | ||||||
Compositional bias | 329-348 | Basic and acidic residues | ||||
Sequence: EQEETTKEEWSQDFKDEGLG |
Domain
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 5 isoforms produced by Alternative splicing.
Q7Z5B4-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Synonymsa
- Length369
- Mass (Da)41,092
- Last updated2003-10-01 v1
- Checksum15FD70384070345D
Q7Z5B4-2
- Name2
- Synonymsd
Q7Z5B4-3
- Name3
- Synonymsc
- Differences from canonical
- 41-222: Missing
Q7Z5B4-5
- Name4
- Synonymsb
- Differences from canonical
- 174-174: Missing
Q7Z5B4-6
- Name5
- Synonymse
- Differences from canonical
- 143-224: TSFELAQLQEKLKETEAAMEKLINRVGPNGESRAQTVTSDQEKRLLHQLREITRVMKEGKFIDRFSPEKEAEEAPYMEDWEG → S
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for sequence conflict, alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 23 | in Ref. 1; AAP92163 | ||||
Sequence: Missing | ||||||
Alternative sequence | VSP_027939 | 41-222 | in isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_027940 | 118-128 | in isoform 2 | |||
Sequence: LSKGKTTAEDG → VSRIILIILHQ | ||||||
Sequence conflict | 124 | In isoform Q7Z5B4-2; in Ref. 1; AAP92163 | ||||
Sequence: I → T | ||||||
Alternative sequence | VSP_027941 | 129-369 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_043786 | 143-224 | in isoform 5 | |||
Sequence: TSFELAQLQEKLKETEAAMEKLINRVGPNGESRAQTVTSDQEKRLLHQLREITRVMKEGKFIDRFSPEKEAEEAPYMEDWEG → S | ||||||
Sequence conflict | 165 | in Ref. 8; AAH22455 | ||||
Sequence: I → F | ||||||
Alternative sequence | VSP_027943 | 174 | in isoform 4 | |||
Sequence: Missing | ||||||
Compositional bias | 329-348 | Basic and acidic residues | ||||
Sequence: EQEETTKEEWSQDFKDEGLG |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY326435 EMBL· GenBank· DDBJ | AAP92162.1 EMBL· GenBank· DDBJ | mRNA | ||
AY326436 EMBL· GenBank· DDBJ | AAP92163.1 EMBL· GenBank· DDBJ | mRNA | ||
AM422214 EMBL· GenBank· DDBJ | CAM12309.1 EMBL· GenBank· DDBJ | mRNA | ||
AY358475 EMBL· GenBank· DDBJ | AAQ88839.1 EMBL· GenBank· DDBJ | mRNA | ||
AK021670 EMBL· GenBank· DDBJ | BAB13871.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
AK315379 EMBL· GenBank· DDBJ | BAG37772.1 EMBL· GenBank· DDBJ | mRNA | ||
AL832601 EMBL· GenBank· DDBJ | CAD89943.1 EMBL· GenBank· DDBJ | mRNA | ||
AC091013 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC116456 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC129895 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471064 EMBL· GenBank· DDBJ | EAW68628.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471064 EMBL· GenBank· DDBJ | EAW68630.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC022455 EMBL· GenBank· DDBJ | AAH22455.1 EMBL· GenBank· DDBJ | mRNA |