These results support that loss of EMP2 is common and its re-expression may serve as an approach to enhance radiation sensitivity in nasopharyngeal carcinoma.
Experiments in vitro using human trophoblast cells lines indicate that EMP2 modulates angiogenesis by altering HIF-1alpha expression. The results reveal a novel role for EMP2 in regulating trophoblast function and vascular development in mice and humans and suggest that it may be a new biomarker for placental insufficiency.
a novel SNP x SNP interaction between rs2267668 in PPARdelta and rs7191411 in EMP2 that has significant impact on circulating HDL-C levels in the Singaporean Chinese population.
All studied ERMs and PVR membranes express EMP2. Levels of EMP2 trended higher in all PVR subgroups than in ERMs especially in inflammatory and traumatic PVR.
The studies implicating GAS3 protein family (EMP1 EMP2 EMP3 and PMP22) in cancer pathogenesis as well as probe the structural similarities between the family members were highlighted.
Data show that loss of epithelial membrane protein 2 (EMP2) is involved in sphingosylphosphorylcholine (SPC)-induced phosphorylation of keratin 8 (K8) via ubiquitination of protein phosphatase 2 (PP2A) through alpha4 phosphoprotein by caveolin-1 (cav-1).
EMP2 plays a tumor suppressor role by inducing G2/M cell cycle arrest suppressing cell viability proliferation colony formation/ anchorage-independent cell growth via regulation of G2/M checkpoints in distinct-derived cell lines.
We showed that knockdown of EMP2 in podocytes and endothelial cells resulted in an increased amount of CAVEOLIN-1 and decreased cell proliferation so EMP2 mutations causes a recessive Mendelian form of steroid-sensitive nephrotic syndrome.
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