Q7Z3V5 · ZN571_HUMAN
- ProteinZinc finger protein 571
- GeneZNF571
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids609 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
May be involved in transcriptional regulation.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
The subsequence PHLLVTFRDVAIDFSQEEWECLDPAQRDLYRDVMLENYSNLISLDLESSCVTKKLSPEKEIYEMESLQWENMGKRINHHL, which contains the KRAB domain, shows transcriptional repressor activity in a high-throughput recruitment assay.
Names & Taxonomy
Protein names
- Recommended nameZinc finger protein 571
Gene names
- Community suggested namesZNF571
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ7Z3V5
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_052869 | 170 | in dbSNP:rs16973893 | |||
Sequence: K → M | ||||||
Natural variant | VAR_023953 | 189 | in dbSNP:rs8111790 | |||
Sequence: Q → H | ||||||
Natural variant | VAR_023954 | 252 | in dbSNP:rs28512414 | |||
Sequence: E → D | ||||||
Natural variant | VAR_023955 | 573 | in dbSNP:rs4802029 | |||
Sequence: L → H | ||||||
Natural variant | VAR_031093 | 593 | in dbSNP:rs16973890 | |||
Sequence: K → E |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 808 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000047662 | 1-609 | Zinc finger protein 571 | |||
Sequence: MPHLLVTFRDVAIDFSQEEWECLDPAQRDLYRDVMLENYSNLISLDLESSCVTKKLSPEKEIYEMESLQWENMGKRINHHLQYNGLGDNMECKGNLEGQEASQEGLYMCVKITCEEKATESHSTSSTFHRIIPTKEKLYKCKECRQGFSYLSCLIQHEENHNIEKCSEVKKHRNTFSKKPSYIQHQRIQTGEKPYECMECGKAFGRTSDLIQHQKIHTNEKPYQCNACGKAFIRGSQLTEHQRVHTGEKPYECKKCGKAFSYCSQYTLHQRIHSGEKPYECKDCGKAFILGSQLTYHQRIHSGEKPYECKECGKAFILGSHLTYHQRVHTGEKPYICKECGKAFLCASQLNEHQRIHTGEKPYECKECGKTFFRGSQLTYHLRVHSGERPYKCKECGKAFISNSNLIQHQRIHTGEKPYKCKECGKAFICGKQLSEHQRIHTGEKPFECKECGKAFIRVAYLTQHEKIHGEKHYECKECGKTFVRATQLTYHQRIHTGEKPYKCKECDKAFIYGSQLSEHQRIHRGEKPYECKQCGKAFIRGSHLTEHLRTHTGEKPYECKECGRAFSRGSELTLHQRIHTGEKPYTCVQCGKDFRCPSQLTQHTRLHN |
Proteomic databases
PTM databases
Expression
Structure
Family & Domains
Features
Showing features for domain, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 6-84 | KRAB | ||||
Sequence: VTFRDVAIDFSQEEWECLDPAQRDLYRDVMLENYSNLISLDLESSCVTKKLSPEKEIYEMESLQWENMGKRINHHLQYN | ||||||
Zinc finger | 139-161 | C2H2-type 1 | ||||
Sequence: YKCKECRQGFSYLSCLIQHEENH | ||||||
Zinc finger | 164-189 | C2H2-type 2; atypical | ||||
Sequence: EKCSEVKKHRNTFSKKPSYIQHQRIQ | ||||||
Zinc finger | 195-217 | C2H2-type 3 | ||||
Sequence: YECMECGKAFGRTSDLIQHQKIH | ||||||
Zinc finger | 223-245 | C2H2-type 4 | ||||
Sequence: YQCNACGKAFIRGSQLTEHQRVH | ||||||
Zinc finger | 251-273 | C2H2-type 5 | ||||
Sequence: YECKKCGKAFSYCSQYTLHQRIH | ||||||
Zinc finger | 279-301 | C2H2-type 6 | ||||
Sequence: YECKDCGKAFILGSQLTYHQRIH | ||||||
Zinc finger | 307-329 | C2H2-type 7 | ||||
Sequence: YECKECGKAFILGSHLTYHQRVH | ||||||
Zinc finger | 335-357 | C2H2-type 8 | ||||
Sequence: YICKECGKAFLCASQLNEHQRIH | ||||||
Zinc finger | 363-385 | C2H2-type 9 | ||||
Sequence: YECKECGKTFFRGSQLTYHLRVH | ||||||
Zinc finger | 391-413 | C2H2-type 10 | ||||
Sequence: YKCKECGKAFISNSNLIQHQRIH | ||||||
Zinc finger | 419-441 | C2H2-type 11 | ||||
Sequence: YKCKECGKAFICGKQLSEHQRIH | ||||||
Zinc finger | 447-469 | C2H2-type 12 | ||||
Sequence: FECKECGKAFIRVAYLTQHEKIH | ||||||
Zinc finger | 474-496 | C2H2-type 13 | ||||
Sequence: YECKECGKTFVRATQLTYHQRIH | ||||||
Zinc finger | 502-524 | C2H2-type 14 | ||||
Sequence: YKCKECDKAFIYGSQLSEHQRIH | ||||||
Zinc finger | 530-552 | C2H2-type 15 | ||||
Sequence: YECKQCGKAFIRGSHLTEHLRTH | ||||||
Zinc finger | 558-580 | C2H2-type 16 | ||||
Sequence: YECKECGRAFSRGSELTLHQRIH | ||||||
Zinc finger | 586-608 | C2H2-type 17 | ||||
Sequence: YTCVQCGKDFRCPSQLTQHTRLH |
Sequence similarities
Belongs to the krueppel C2H2-type zinc-finger protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length609
- Mass (Da)70,792
- Last updated2007-03-20 v3
- Checksum7DAA91B38A806EF1
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 62 | in Ref. 2; CAD97643 | ||||
Sequence: I → V | ||||||
Sequence conflict | 102 | in Ref. 3; AAH40591 | ||||
Sequence: S → N |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF161544 EMBL· GenBank· DDBJ | AAF29031.2 EMBL· GenBank· DDBJ | mRNA | ||
BX537401 EMBL· GenBank· DDBJ | CAD97643.1 EMBL· GenBank· DDBJ | mRNA | ||
BC040591 EMBL· GenBank· DDBJ | AAH40591.1 EMBL· GenBank· DDBJ | mRNA | ||
BC113870 EMBL· GenBank· DDBJ | AAI13871.1 EMBL· GenBank· DDBJ | mRNA |