Q7YS44 · FMO3_PANTR

Function

function

Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.

Catalytic activity

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site9-13FAD (UniProtKB | ChEBI)
Binding site32FAD (UniProtKB | ChEBI)
Binding site40-41FAD (UniProtKB | ChEBI)
Binding site60-61NADP+ (UniProtKB | ChEBI)
Binding site61-62FAD (UniProtKB | ChEBI)
Binding site195-198NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionalbendazole monooxygenase activity
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionhypotaurine dehydrogenase activity
Molecular FunctionN,N-dimethylaniline monooxygenase activity
Molecular FunctionNADP binding
Molecular Functiontrimethylamine monooxygenase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Flavin-containing monooxygenase 3
  • EC number
  • Alternative names
    • Dimethylaniline monooxygenase [N-oxide-forming] 3
    • Dimethylaniline oxidase 3
    • Hepatic flavin-containing monooxygenase 3 (FMO 3)
    • Trimethylamine monooxygenase

Gene names

    • Name
      FMO3

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan

Accessions

  • Primary accession
    Q7YS44

Proteomes

Organism-specific databases

Subcellular Location

Microsome membrane
; Single-pass membrane protein
Endoplasmic reticulum membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane510-530Helical

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001476571-532Flavin-containing monooxygenase 3
Modified residue401Phosphoserine

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the FMO family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    532
  • Mass (Da)
    60,052
  • Last updated
    2007-01-23 v3
  • Checksum
    11B75102F9A7DD66
MGKKVAIIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGGLWKFSDHAEEGRASIYKSVFSNSSKEMMCFPDFPFPDDFPNFMHNSKIQEYIIAFAKEKNLLKYIQFKTFVSSVNKRPDFATTGQWDVTTERDGKKESAVFDAVMVCSGHHVYPNLPKESFPGLNHFKGKCFHSRDYKEPGVFNGKRVLVVGLGNSGCDIATELSRTAEQVMISSRSGSWVMSRVWDNGYPWDMLLVTRFGTFLKNNLPTAISDWLYVKQMNARFKHENYGLMPLNGVLRKEPVFNDELPASILCGIVSVKPNVKEFTETSAIFEDGTIFEGIDCVIFATGYSFAYPFLDESIIKSRNNEIILFKGVFPPLLEKSTIAVIGFVQSLGAAIPTVDLQSRWAAQVIKGTCTLPSMEDMMNDINEKMEKKRKWFGKSETIQTDYIVYMDELSSFIGAKPNIPWLFLTDPKLAMEVYFGPCSPYQFRLVGPGQWPGARNAILTQWDRSLKPMQTRVVGRLQKPCFFFHWLKLFAIPILLIAVFLVLT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY082442
EMBL· GenBank· DDBJ
AAP57529.1
EMBL· GenBank· DDBJ
Genomic DNA
AY063499
EMBL· GenBank· DDBJ
AAP57529.1
EMBL· GenBank· DDBJ
Genomic DNA
AY082436
EMBL· GenBank· DDBJ
AAP57529.1
EMBL· GenBank· DDBJ
Genomic DNA
AY082437
EMBL· GenBank· DDBJ
AAP57529.1
EMBL· GenBank· DDBJ
Genomic DNA
AY082438
EMBL· GenBank· DDBJ
AAP57529.1
EMBL· GenBank· DDBJ
Genomic DNA
AY082439
EMBL· GenBank· DDBJ
AAP57529.1
EMBL· GenBank· DDBJ
Genomic DNA
AY082440
EMBL· GenBank· DDBJ
AAP57529.1
EMBL· GenBank· DDBJ
Genomic DNA
AY082441
EMBL· GenBank· DDBJ
AAP57529.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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