Q7YS44 · FMO3_PANTR
- ProteinFlavin-containing monooxygenase 3
- GeneFMO3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids532 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
Catalytic activity
- NADPH + O2 + trimethylamine = H2O + NADP+ + trimethylamine N-oxideThis reaction proceeds in the forward direction.
- (S)-nicotine + NADPH + O2 = H2O + NADP+ + trans-(S)-nicotine N(1')-oxideThis reaction proceeds in the forward direction.
Cofactor
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 9-13 | FAD (UniProtKB | ChEBI) | ||||
Sequence: GAGVS | ||||||
Binding site | 32 | FAD (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 40-41 | FAD (UniProtKB | ChEBI) | ||||
Sequence: LW | ||||||
Binding site | 60-61 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: SN | ||||||
Binding site | 61-62 | FAD (UniProtKB | ChEBI) | ||||
Sequence: NS | ||||||
Binding site | 195-198 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: SGCD |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | albendazole monooxygenase activity | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | hypotaurine dehydrogenase activity | |
Molecular Function | N,N-dimethylaniline monooxygenase activity | |
Molecular Function | NADP binding | |
Molecular Function | trimethylamine monooxygenase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFlavin-containing monooxygenase 3
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Pan
Accessions
- Primary accessionQ7YS44
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Microsome membrane ; Single-pass membrane protein
Endoplasmic reticulum membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 510-530 | Helical | ||||
Sequence: FFFHWLKLFAIPILLIAVFLV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000147657 | 1-532 | Flavin-containing monooxygenase 3 | |||
Sequence: MGKKVAIIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGGLWKFSDHAEEGRASIYKSVFSNSSKEMMCFPDFPFPDDFPNFMHNSKIQEYIIAFAKEKNLLKYIQFKTFVSSVNKRPDFATTGQWDVTTERDGKKESAVFDAVMVCSGHHVYPNLPKESFPGLNHFKGKCFHSRDYKEPGVFNGKRVLVVGLGNSGCDIATELSRTAEQVMISSRSGSWVMSRVWDNGYPWDMLLVTRFGTFLKNNLPTAISDWLYVKQMNARFKHENYGLMPLNGVLRKEPVFNDELPASILCGIVSVKPNVKEFTETSAIFEDGTIFEGIDCVIFATGYSFAYPFLDESIIKSRNNEIILFKGVFPPLLEKSTIAVIGFVQSLGAAIPTVDLQSRWAAQVIKGTCTLPSMEDMMNDINEKMEKKRKWFGKSETIQTDYIVYMDELSSFIGAKPNIPWLFLTDPKLAMEVYFGPCSPYQFRLVGPGQWPGARNAILTQWDRSLKPMQTRVVGRLQKPCFFFHWLKLFAIPILLIAVFLVLT | ||||||
Modified residue | 401 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length532
- Mass (Da)60,052
- Last updated2007-01-23 v3
- Checksum11B75102F9A7DD66
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY082442 EMBL· GenBank· DDBJ | AAP57529.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY063499 EMBL· GenBank· DDBJ | AAP57529.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY082436 EMBL· GenBank· DDBJ | AAP57529.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY082437 EMBL· GenBank· DDBJ | AAP57529.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY082438 EMBL· GenBank· DDBJ | AAP57529.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY082439 EMBL· GenBank· DDBJ | AAP57529.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY082440 EMBL· GenBank· DDBJ | AAP57529.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY082441 EMBL· GenBank· DDBJ | AAP57529.1 EMBL· GenBank· DDBJ | Genomic DNA |