Q7YCF7 · Q7YCF7_HUMAN

  • Protein
    NADH-ubiquinone oxidoreductase chain 4
  • Gene
    ND4
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Biological ProcessATP synthesis coupled electron transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 4
  • EC number

Gene names

    • Name
      ND4

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • LN7595
    • UasiQ2a001
    • AS26
    • Tzsw010_L0d
    • Aus33
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q7YCF7

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein
Mitochondrion membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane21-41Helical
Transmembrane148-167Helical
Transmembrane196-216Helical
Transmembrane223-244Helical
Transmembrane256-277Helical
Transmembrane284-303Helical
Transmembrane309-330Helical
Transmembrane351-369Helical
Transmembrane389-409Helical

Keywords

PTM/Processing

Proteomic databases

Interaction

Subunit

Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-109NADH:ubiquinone oxidoreductase chain 4 N-terminal
Domain112-397NADH:quinone oxidoreductase/Mrp antiporter membrane subunit

Sequence similarities

Belongs to the complex I subunit 4 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    459
  • Mass (Da)
    51,641
  • Last updated
    2003-10-01 v1
  • Checksum
    8444F6A48FC362AE
MLKLIVPTIMLLPLTWLSKKHMIWINTTTHSLIISIIPLLFFNQINNNLFSCSPTFSSDPLTTPLLMLTTWLLPLTIMASQRHLSSEPLSRKKLYLSMLIFLQISLIMTFTATELIMFYIFFETTLIPTLAIITRWGNQPERLNAGTYFLFYTLVGSLPLLIALIYTHNTLGSLNILLLTLTAQELSNSWANNLMWLAYTMAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAVLLKLGGYGMMRLTLILNPLTKHMAYPFLVLSLWGMIMTSSICLRQTDLKSLIAYSSISHMALVVTAILIQTPWSFTGAVILMIAHGLTSSLLFCLANSNYERTHSRIMILSQGLQTLLPLMAFWWLLASLANLALPPTINLLGELSVLVTTFSWSNITLLLTGLNMLVTALYSLYMFTTTQWGSLTHHINNMKPSFTRENTLMFMHLSPILLLSLNPDIITGFSS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY255147
EMBL· GenBank· DDBJ
AAO66809.1
EMBL· GenBank· DDBJ
Genomic DNA
AY956412
EMBL· GenBank· DDBJ
AAX45445.1
EMBL· GenBank· DDBJ
Genomic DNA
DQ112788
EMBL· GenBank· DDBJ
AAZ01121.1
EMBL· GenBank· DDBJ
Genomic DNA
EF184588
EMBL· GenBank· DDBJ
ABO39331.1
EMBL· GenBank· DDBJ
Genomic DNA
EF495218
EMBL· GenBank· DDBJ
ABO70928.1
EMBL· GenBank· DDBJ
Genomic DNA
EU092842
EMBL· GenBank· DDBJ
ABU66371.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ748721
EMBL· GenBank· DDBJ
ACN37346.1
EMBL· GenBank· DDBJ
Genomic DNA
FJ969382
EMBL· GenBank· DDBJ
ACQ73888.1
EMBL· GenBank· DDBJ
Genomic DNA
GU392099
EMBL· GenBank· DDBJ
ADN42351.1
EMBL· GenBank· DDBJ
Genomic DNA
JF824897
EMBL· GenBank· DDBJ
AEG63218.1
EMBL· GenBank· DDBJ
Genomic DNA
JN857012
EMBL· GenBank· DDBJ
AET09005.1
EMBL· GenBank· DDBJ
Genomic DNA
JX289133
EMBL· GenBank· DDBJ
AFP96480.1
EMBL· GenBank· DDBJ
Genomic DNA
KC345931
EMBL· GenBank· DDBJ
AGD84067.1
EMBL· GenBank· DDBJ
Genomic DNA
KC533475
EMBL· GenBank· DDBJ
AGK64422.1
EMBL· GenBank· DDBJ
Genomic DNA
KF450936
EMBL· GenBank· DDBJ
AGZ65810.1
EMBL· GenBank· DDBJ
Genomic DNA
KF672823
EMBL· GenBank· DDBJ
AHA47740.1
EMBL· GenBank· DDBJ
Genomic DNA
KF849948
EMBL· GenBank· DDBJ
AHE79221.1
EMBL· GenBank· DDBJ
Genomic DNA
KJ154178
EMBL· GenBank· DDBJ
AHW29982.1
EMBL· GenBank· DDBJ
Genomic DNA
KT725950
EMBL· GenBank· DDBJ
ANA93159.1
EMBL· GenBank· DDBJ
Genomic DNA
KX228175
EMBL· GenBank· DDBJ
ANP95228.1
EMBL· GenBank· DDBJ
Genomic DNA
KX456813
EMBL· GenBank· DDBJ
APD57608.1
EMBL· GenBank· DDBJ
Genomic DNA
KY686216
EMBL· GenBank· DDBJ
ARH56317.1
EMBL· GenBank· DDBJ
Genomic DNA
MF057324
EMBL· GenBank· DDBJ
ASS14123.1
EMBL· GenBank· DDBJ
Genomic DNA
MF696069
EMBL· GenBank· DDBJ
AUT80015.1
EMBL· GenBank· DDBJ
Genomic DNA
MG244212
EMBL· GenBank· DDBJ
AUZ22902.1
EMBL· GenBank· DDBJ
Genomic DNA
MH449100
EMBL· GenBank· DDBJ
AYW06021.1
EMBL· GenBank· DDBJ
Genomic DNA
MH553648
EMBL· GenBank· DDBJ
QBY36432.1
EMBL· GenBank· DDBJ
Genomic DNA
MK248286
EMBL· GenBank· DDBJ
QFV14508.1
EMBL· GenBank· DDBJ
Genomic DNA
MN398766
EMBL· GenBank· DDBJ
QIQ24514.1
EMBL· GenBank· DDBJ
Genomic DNA
MN849836
EMBL· GenBank· DDBJ
QKT26411.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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