Q7Y7K9 · Q7Y7K9_HUMAN
- ProteinCytochrome c oxidase subunit 1
- GeneCOX1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids513 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + 8 H+(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H+(out) + 2 H2OThis reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + 8 H+ (in)CHEBI:15378+ CHEBI:15379 = 4 RHEA-COMP:14399 + 4 H+ (out)CHEBI:15378+ 2 CHEBI:15377
Cofactor
Protein has several cofactor binding sites:
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | oxidative phosphorylation |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ7Y7K9
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 18-37 | Helical | ||||
Sequence: LYLLFGAWAGVLGTALSLLI | ||||||
Transmembrane | 57-83 | Helical | ||||
Sequence: IVTAHAFVMIFFMVMPIMIGGFGNWLV | ||||||
Transmembrane | 104-128 | Helical | ||||
Sequence: LLPPSLLLLLASATVEAGAGTGWTV | ||||||
Transmembrane | 148-171 | Helical | ||||
Sequence: FSLHLAGVSSILGAINFITTIINM | ||||||
Transmembrane | 183-210 | Helical | ||||
Sequence: LFVWSVLITAVLLLLSLPVLAAGITMLL | ||||||
Transmembrane | 243-261 | Helical | ||||
Sequence: VYILILPGFGMISHIVTYY | ||||||
Transmembrane | 268-291 | Helical | ||||
Sequence: FGYMGMVWAMMSIGFLGFIVWAHH | ||||||
Transmembrane | 303-325 | Helical | ||||
Sequence: AYFTSATMIIAIPTGVKVFSWLA | ||||||
Transmembrane | 337-359 | Helical | ||||
Sequence: AVLWALGFIFLFTVGGLTGIVLA | ||||||
Transmembrane | 379-400 | Helical | ||||
Sequence: YVLSMGAVFAIMGGFIHWFPLF | ||||||
Transmembrane | 412-430 | Helical | ||||
Sequence: IHFTIMFIGVNLTFFPQHF | ||||||
Transmembrane | 450-473 | Helical | ||||
Sequence: WNILSSVGSFISLTAVMLMIFMIW |
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-511 | Cytochrome oxidase subunit I profile | ||||
Sequence: MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASATVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEPVYM |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length513
- Mass (Da)57,011
- Last updated2003-10-01 v1
- Checksum463E64636839BEB7
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY255169 EMBL· GenBank· DDBJ | AAO67087.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY289091 EMBL· GenBank· DDBJ | AAP48402.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY495146 EMBL· GenBank· DDBJ | AAR93226.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY713995 EMBL· GenBank· DDBJ | AAU02373.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY738960 EMBL· GenBank· DDBJ | AAU13214.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY963577 EMBL· GenBank· DDBJ | AAX53739.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ112862 EMBL· GenBank· DDBJ | AAZ02076.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ272115 EMBL· GenBank· DDBJ | ABB51348.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ282402 EMBL· GenBank· DDBJ | ABB78288.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DQ372873 EMBL· GenBank· DDBJ | ABC96451.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EF657726 EMBL· GenBank· DDBJ | ABR99397.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU200765 EMBL· GenBank· DDBJ | ABW72966.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
EU600353 EMBL· GenBank· DDBJ | ACD44103.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ384437 EMBL· GenBank· DDBJ | ACI95183.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ442939 EMBL· GenBank· DDBJ | ACJ44206.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ348171 EMBL· GenBank· DDBJ | ACJ59791.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ544230 EMBL· GenBank· DDBJ | ACK76868.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ383769 EMBL· GenBank· DDBJ | ACM77125.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ748704 EMBL· GenBank· DDBJ | ACN37118.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FJ770957 EMBL· GenBank· DDBJ | ACN49709.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GQ119025 EMBL· GenBank· DDBJ | ACS48794.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU377087 EMBL· GenBank· DDBJ | ADB78214.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM030529 EMBL· GenBank· DDBJ | ADE33457.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM185219 EMBL· GenBank· DDBJ | ADK61393.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
HM852832 EMBL· GenBank· DDBJ | ADL30884.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
GU392090 EMBL· GenBank· DDBJ | ADN42227.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JF824829 EMBL· GenBank· DDBJ | AEG62327.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN580302 EMBL· GenBank· DDBJ | AEO89809.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JN857020 EMBL· GenBank· DDBJ | AET09102.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ324533 EMBL· GenBank· DDBJ | AFA28691.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ701892 EMBL· GenBank· DDBJ | AFF62556.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JQ797872 EMBL· GenBank· DDBJ | AFI51086.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX152825 EMBL· GenBank· DDBJ | AFO20900.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JX289113 EMBL· GenBank· DDBJ | AFP96213.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC152560 EMBL· GenBank· DDBJ | AFY51667.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC505096 EMBL· GenBank· DDBJ | AGI49918.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC994014 EMBL· GenBank· DDBJ | AGO23169.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC911289 EMBL· GenBank· DDBJ | AGO90499.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF056263 EMBL· GenBank· DDBJ | AGT52608.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KC252338 EMBL· GenBank· DDBJ | AGX89773.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF540541 EMBL· GenBank· DDBJ | AGZ06327.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF451474 EMBL· GenBank· DDBJ | AGZ72797.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF148131 EMBL· GenBank· DDBJ | AGZ96552.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KF849935 EMBL· GenBank· DDBJ | AHE79045.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ801427 EMBL· GenBank· DDBJ | AIL91411.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KJ856688 EMBL· GenBank· DDBJ | AIN37439.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM101994 EMBL· GenBank· DDBJ | AIU62623.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KM986579 EMBL· GenBank· DDBJ | AJV87651.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KP346023 EMBL· GenBank· DDBJ | AKC00026.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU131383 EMBL· GenBank· DDBJ | AMB50870.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KU521429 EMBL· GenBank· DDBJ | AMK46685.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KT725883 EMBL· GenBank· DDBJ | ANA92285.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX457178 EMBL· GenBank· DDBJ | APD62345.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KX675304 EMBL· GenBank· DDBJ | APZ83650.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY595632 EMBL· GenBank· DDBJ | ARD72842.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY686206 EMBL· GenBank· DDBJ | ARH56180.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY824949 EMBL· GenBank· DDBJ | ARK16718.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF362699 EMBL· GenBank· DDBJ | ASF83785.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF362932 EMBL· GenBank· DDBJ | ASF86812.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY645719 EMBL· GenBank· DDBJ | ASR15126.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF057327 EMBL· GenBank· DDBJ | ASS14155.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF498666 EMBL· GenBank· DDBJ | ASY00263.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MF695982 EMBL· GenBank· DDBJ | AUT78877.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG272769 EMBL· GenBank· DDBJ | AVL87419.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MG952875 EMBL· GenBank· DDBJ | AWX65355.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH449124 EMBL· GenBank· DDBJ | AYW06323.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008260 EMBL· GenBank· DDBJ | BAE07365.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP008568 EMBL· GenBank· DDBJ | BAE11371.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AP010708 EMBL· GenBank· DDBJ | BAG15006.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK128860 EMBL· GenBank· DDBJ | QBB88070.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MH553659 EMBL· GenBank· DDBJ | QBY36568.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK059529 EMBL· GenBank· DDBJ | QCB17087.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK491423 EMBL· GenBank· DDBJ | QEG55939.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MK134283 EMBL· GenBank· DDBJ | QGW53976.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN849597 EMBL· GenBank· DDBJ | QKT23297.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN687190 EMBL· GenBank· DDBJ | QLH91300.1 EMBL· GenBank· DDBJ | Genomic DNA |