Q7XU27 · BRE1A_ORYSJ
- ProteinE3 ubiquitin-protein ligase BRE1-like 1
- GeneHUB1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids884 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
E3 ubiquitin-protein ligase that monoubiquitinates H2B to form H2BK143ub1. H2BK143ub1 gives a specific tag for epigenetic transcriptional activation and is a prerequisite for H3 Lys-4 methylation (H3K4me). It thereby plays a central role in histone code and gene regulation. H2B monoubiquitination (H2BK143ub1), mediated by HUB1, modulates transcriptional regulation of anther development, likely by promoting histone H3K4 dimethylation (H3K4me2) in the chromatin of the key tapetum degradation-related genes C4, CP1 and UDT1.
Catalytic activity
Pathway
Protein modification; protein ubiquitination.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | HULC complex | |
Cellular Component | nucleus | |
Molecular Function | metal ion binding | |
Molecular Function | protein homodimerization activity | |
Molecular Function | ubiquitin protein ligase activity | |
Biological Process | cell division | |
Biological Process | chromatin organization | |
Biological Process | defense response to fungus | |
Biological Process | flower development | |
Biological Process | innate immune response | |
Biological Process | leaf morphogenesis | |
Biological Process | positive regulation of cell division | |
Biological Process | protein monoubiquitination | |
Biological Process | regulation of G2/M transition of mitotic cell cycle | |
Biological Process | seed dormancy process | |
Biological Process | vegetative to reproductive phase transition of meristem |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameE3 ubiquitin-protein ligase BRE1-like 1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza > Oryza sativa
Accessions
- Primary accessionQ7XU27
- Secondary accessions
Proteomes
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Semi-dwarf plants, early heading, and partial sterility of spikelets due to defects in the anther developmental program and pollen formation.
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000293110 | 1-884 | UniProt | E3 ubiquitin-protein ligase BRE1-like 1 | |||
Sequence: MGSTGEPDRKRRLSSSVAPGGGAPVSPAKRLAVAPTSEDKKLDFTVLKYKNQKLSEQLEAHKFEYRALENKFAGLKEKQRTHNETLSLVNSSWEQLVADLKSRSFCKSGSPNSSPGSGHNNVQKDGTCAPIERDTLRSLVESGATESSGCLPGCHLGSDAPPLHLSTANALGDIFFPSSDLLQANEECALAALTKLPENDRSKQLQSTSSNLLSSLNNVVQALSNLQLKHKQLAEDYQNQRDSSARKRAEHRRLKEELASAASELEETNYKLAALKAQRDNTQGARIPYPTLGNKNMPEDKVRDKQREMQDLEATHKELSELISKRLVEIKRLHEERIEILNKIATFQNILMDFKSIRSSKAFQLVNDRLQKSQAELDHYQTLLEKLQVDKDKFVWQERQFNLKVDLAEIPERVSTYCESSIADLKKDIQKLCDEKNMLILKLEEASREPGRNQVITKFKALVSSIPREMGAMQSEMTKHKEASLELNSLRAEVHSLSRILSRKERDNEEASCRSARAGSDITQLQSVISDLKQTNKELKLFADMYKRESTDSREIMESRDREFLEWAHVHALKSSLDESKLEQRVKAANEAEAITQQRLATAEAEIAESGQKLGTSRKDLVSLSHMLKSKQEECEAYRVEVECIGQAYEDIQAQNQQLLQQIIERDDDNTKIFMEGVKAKQTQDALHLETYSLRRNLQQESSLMDLYNQKIVSLEDQLKMWSDRVGKLQEDGWQQSVSLSNYQRKLVDVHRDAQKLMQSLDGIQANVGSSRLEVADLLIELEKERFSKKRIEDDLEVMSRKASSLRAKARESAVLEKLRHEVKEYRGILKCGICHDRQKEVVITKCYHLFCNQCIQKSLGNRQRRCPSCSLSFGANDVKPIYI | |||||||
Modified residue (large scale data) | 26 | PTMeXchange | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 110 | PTMeXchange | Phosphoserine | ||||
Sequence: S |
Proteomic databases
Structure
Family & Domains
Features
Showing features for region, coiled coil, compositional bias, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-37 | Disordered | ||||
Sequence: MGSTGEPDRKRRLSSSVAPGGGAPVSPAKRLAVAPTS | ||||||
Coiled coil | 49-86 | |||||
Sequence: YKNQKLSEQLEAHKFEYRALENKFAGLKEKQRTHNETL | ||||||
Compositional bias | 107-124 | Polar residues | ||||
Sequence: KSGSPNSSPGSGHNNVQK | ||||||
Region | 107-127 | Disordered | ||||
Sequence: KSGSPNSSPGSGHNNVQKDGT | ||||||
Coiled coil | 216-541 | |||||
Sequence: LNNVVQALSNLQLKHKQLAEDYQNQRDSSARKRAEHRRLKEELASAASELEETNYKLAALKAQRDNTQGARIPYPTLGNKNMPEDKVRDKQREMQDLEATHKELSELISKRLVEIKRLHEERIEILNKIATFQNILMDFKSIRSSKAFQLVNDRLQKSQAELDHYQTLLEKLQVDKDKFVWQERQFNLKVDLAEIPERVSTYCESSIADLKKDIQKLCDEKNMLILKLEEASREPGRNQVITKFKALVSSIPREMGAMQSEMTKHKEASLELNSLRAEVHSLSRILSRKERDNEEASCRSARAGSDITQLQSVISDLKQTNKELKL | ||||||
Coiled coil | 580-663 | |||||
Sequence: SKLEQRVKAANEAEAITQQRLATAEAEIAESGQKLGTSRKDLVSLSHMLKSKQEECEAYRVEVECIGQAYEDIQAQNQQLLQQI | ||||||
Coiled coil | 696-762 | |||||
Sequence: RNLQQESSLMDLYNQKIVSLEDQLKMWSDRVGKLQEDGWQQSVSLSNYQRKLVDVHRDAQKLMQSLD | ||||||
Coiled coil | 789-827 | |||||
Sequence: KKRIEDDLEVMSRKASSLRAKARESAVLEKLRHEVKEYR | ||||||
Zinc finger | 832-871 | RING-type | ||||
Sequence: CGICHDRQKEVVITKCYHLFCNQCIQKSLGNRQRRCPSCS |
Domain
The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
Sequence similarities
Belongs to the BRE1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length884
- Mass (Da)100,373
- Last updated2007-07-10 v3
- ChecksumC01CB1684FB0DF2A
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 107-124 | Polar residues | ||||
Sequence: KSGSPNSSPGSGHNNVQK |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL663000 EMBL· GenBank· DDBJ | CAD41603.3 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AP008210 EMBL· GenBank· DDBJ | BAF15403.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AP014960 EMBL· GenBank· DDBJ | BAS90372.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CM000141 EMBL· GenBank· DDBJ | EEE61450.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK067475 EMBL· GenBank· DDBJ | - | mRNA | No translation available. |