Q7X279 · SDGA_STRSQ

  • Protein
    Salicylyl-CoA synthase / salicylate adenylyltransferase
  • Gene
    sdgA
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Involved in the degradation of salicylate via a pathway involving coenzyme A derivative. Catalyzes the conversion of salicylate to salicyloyl-CoA via the formation of a salicylate-adenylate intermediate. The substrate specificity is strong, since benzoate, 3-hydroxybenzoate, 4-hydroxybenzoate, gentisate, 2-aminobenzoate, aminobenzoate, salicylamide, salicylaldoxime and 2-hydroxyphenyl acetate cannot substitute for salicylate.

Catalytic activity

Features

Showing features for binding site.

155350100150200250300350400450500550
TypeIDPosition(s)Description
Binding site203ATP (UniProtKB | ChEBI)
Binding site246-247substrate
Binding site320ATP (UniProtKB | ChEBI)
Binding site342ATP (UniProtKB | ChEBI)
Binding site426ATP (UniProtKB | ChEBI)
Binding site441ATP (UniProtKB | ChEBI)
Binding site533ATP (UniProtKB | ChEBI)
Binding site533substrate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular Functionacyltransferase activity, transferring groups other than amino-acyl groups
Molecular FunctionATP binding
Molecular Functionmedium-chain fatty acid-CoA ligase activity
Molecular Functionnucleotidyltransferase activity
Biological Processcatabolic process
Biological Processfatty acid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Salicylyl-CoA synthase / salicylate adenylyltransferase
  • EC number

Gene names

    • Name
      sdgA

Organism names

  • Taxonomic identifier
  • Strain
    • WA46
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces

Accessions

  • Primary accession
    Q7X279

Phenotypes & Variants

Disruption phenotype

Cells lacking this gene are unable to degrade salicylate.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004357391-553Salicylyl-CoA synthase / salicylate adenylyltransferase

Expression

Induction

By salicylate.

Structure

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    553
  • Mass (Da)
    59,350
  • Last updated
    2003-10-01 v1
  • Checksum
    8127A58D18715749
MTREGFVPWPKEAADRYREAGYWRGRPLGSYLHEWAETYGDTVAVVDGDTRLTYRQLVDRADGLACRLLDSGLNPGDAMLVQLPNGWEFVTLTLACLRAGIAPVMAMPAHRGHELRYLAAHAEVTSIAVPDRLGDFDHQALGREVAEDTPSVGLLLVAGGTVGTDATDLRALAEPADDPVTARARLDRIAPDSGDIAVFLLSGGTTGLPKLITRTHDDYEYNARRSAEVCGLDSDSVYLVALPAGHNFPLACPGILGTLMNGGRVVLARTPEPGKVLPLMAAEGVTATAAVPAVVQRWIDAVASGRHPAPPALRLLQVGGARLAPEVARRAEPVLGGTLQQVFGMAEGLLNYTRPDDPDDIKIETQGRPMCPDDEILVVDASDNPVPPGEMGALLTRGPYTPRGYYRAAEHNARAFTPDGWYRTGDVVRLHPSGNLVVEGRDKDLINRGGEKISAEEVENLIYRLPGVARVAAVAKADPDLGERVCAVVVVEPGTQLSLESVRAALTAMQVARYKLPEDLLVVDELPLTKVGKIDKKRLRDVVRGKADSVEAV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB112586
EMBL· GenBank· DDBJ
BAC78380.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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