Q7X279 · SDGA_STRSQ
- ProteinSalicylyl-CoA synthase / salicylate adenylyltransferase
- GenesdgA
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids553 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Involved in the degradation of salicylate via a pathway involving coenzyme A derivative. Catalyzes the conversion of salicylate to salicyloyl-CoA via the formation of a salicylate-adenylate intermediate. The substrate specificity is strong, since benzoate, 3-hydroxybenzoate, 4-hydroxybenzoate, gentisate, 2-aminobenzoate, aminobenzoate, salicylamide, salicylaldoxime and 2-hydroxyphenyl acetate cannot substitute for salicylate.
Catalytic activity
- ATP + CoA + salicylate = 2-hydroxybenzoyl-CoA + AMP + diphosphate
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 203 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 246-247 | substrate | ||||
Sequence: HN | ||||||
Binding site | 320 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 342 | ATP (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 426 | ATP (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 441 | ATP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 533 | ATP (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 533 | substrate | ||||
Sequence: K |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | acyltransferase activity, transferring groups other than amino-acyl groups | |
Molecular Function | ATP binding | |
Molecular Function | medium-chain fatty acid-CoA ligase activity | |
Molecular Function | nucleotidyltransferase activity | |
Biological Process | catabolic process | |
Biological Process | fatty acid metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSalicylyl-CoA synthase / salicylate adenylyltransferase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces
Accessions
- Primary accessionQ7X279
Phenotypes & Variants
Disruption phenotype
Cells lacking this gene are unable to degrade salicylate.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000435739 | 1-553 | Salicylyl-CoA synthase / salicylate adenylyltransferase | |||
Sequence: MTREGFVPWPKEAADRYREAGYWRGRPLGSYLHEWAETYGDTVAVVDGDTRLTYRQLVDRADGLACRLLDSGLNPGDAMLVQLPNGWEFVTLTLACLRAGIAPVMAMPAHRGHELRYLAAHAEVTSIAVPDRLGDFDHQALGREVAEDTPSVGLLLVAGGTVGTDATDLRALAEPADDPVTARARLDRIAPDSGDIAVFLLSGGTTGLPKLITRTHDDYEYNARRSAEVCGLDSDSVYLVALPAGHNFPLACPGILGTLMNGGRVVLARTPEPGKVLPLMAAEGVTATAAVPAVVQRWIDAVASGRHPAPPALRLLQVGGARLAPEVARRAEPVLGGTLQQVFGMAEGLLNYTRPDDPDDIKIETQGRPMCPDDEILVVDASDNPVPPGEMGALLTRGPYTPRGYYRAAEHNARAFTPDGWYRTGDVVRLHPSGNLVVEGRDKDLINRGGEKISAEEVENLIYRLPGVARVAAVAKADPDLGERVCAVVVVEPGTQLSLESVRAALTAMQVARYKLPEDLLVVDELPLTKVGKIDKKRLRDVVRGKADSVEAV |
Expression
Induction
By salicylate.
Structure
Sequence
- Sequence statusComplete
- Length553
- Mass (Da)59,350
- Last updated2003-10-01 v1
- Checksum8127A58D18715749
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB112586 EMBL· GenBank· DDBJ | BAC78380.1 EMBL· GenBank· DDBJ | Genomic DNA |