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Q7WTB1 · GALE_LACHE

Function

function

Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD. It also could be involved in preparation of carbohydrate residues for incorporation into complex polymers, such as exopolysaccharides.

Catalytic activity

Cofactor

NAD+ (UniProtKB | Rhea| CHEBI:57540 )

Pathway

Carbohydrate metabolism; galactose metabolism.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site11-12NAD+ (UniProtKB | ChEBI)
Binding site31-36NAD+ (UniProtKB | ChEBI)
Binding site51-52NAD+ (UniProtKB | ChEBI)
Binding site73-77NAD+ (UniProtKB | ChEBI)
Binding site92NAD+ (UniProtKB | ChEBI)
Binding site117NAD+ (UniProtKB | ChEBI)
Binding site117substrate
Active site141Proton acceptor
Binding site141NAD+ (UniProtKB | ChEBI)
Binding site141substrate
Binding site145NAD+ (UniProtKB | ChEBI)
Binding site169NAD+ (UniProtKB | ChEBI)
Binding site170substrate
Binding site189-190substrate
Binding site206-208substrate
Binding site221substrate
Binding site282-285substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionUDP-glucose 4-epimerase activity
Biological Processgalactose catabolic process via UDP-galactose

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UDP-glucose 4-epimerase
  • EC number
  • Alternative names
    • Galactowaldenase
    • UDP-galactose 4-epimerase

Gene names

    • Name
      galE

Organism names

Accessions

  • Primary accession
    Q7WTB1

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001832081-330UDP-glucose 4-epimerase

Expression

Induction

Seems to be constitutively expressed.

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    330
  • Mass (Da)
    36,429
  • Last updated
    2003-10-01 v1
  • MD5 Checksum
    87518A93904E229C747F0D6EAF03B891
MKVLVIGGAGYIGSHAVRELVKEGNDVLVLDALYTGHRKAVDPKAKFYQGDIEDTFLVSKILRDEKIDAVMHFAAYSLVPESVKKPLKYYDNNVTGMISLLQAMNDANVKYLVFSSSAATYGIPKKLPITEDTPLNPINPYGETKMMMEKIMAWADKADGIKYTALRYFNVAGASSDGSIGEDHAPETHLIPNILKSAISGDGKFTIFGDDYDTKDGTNVRDYVQVEDLIDAHILALKHMMKTNKSDVFNLGTAHGYSNLEILESAKKVTGIDIPYTMGPRRGGDPDSLVADSTKARTVLGWKPKHENVDDVIATAWKWHKSHPKGYEDK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ512879
EMBL· GenBank· DDBJ
CAD55502.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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