Q7VRI8 · METE_BLOFL
- Protein5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
- GenemetE
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids769 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
Catalytic activity
- 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 17-20 | 5-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 118 | 5-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 441-443 | L-homocysteine (UniProtKB | ChEBI) | |||
Binding site | 441-443 | L-methionine (UniProtKB | ChEBI) | |||
Binding site | 494 | L-homocysteine (UniProtKB | ChEBI) | |||
Binding site | 494 | L-methionine (UniProtKB | ChEBI) | |||
Binding site | 525-526 | 5-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 571 | 5-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 609 | L-homocysteine (UniProtKB | ChEBI) | |||
Binding site | 609 | L-methionine (UniProtKB | ChEBI) | |||
Binding site | 615 | 5-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI) | |||
Binding site | 651 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 653 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 675 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Active site | 705 | Proton donor | |||
Binding site | 737 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity | |
Molecular Function | zinc ion binding | |
Biological Process | methionine biosynthetic process | |
Biological Process | methylation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > ant endosymbionts > Candidatus Blochmanniella
Accessions
- Primary accessionQ7VRI8
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000098623 | 1-769 | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase | ||
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length769
- Mass (Da)89,643
- Last updated2003-10-01 v1
- Checksum237481A565500CC2
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX248583 EMBL· GenBank· DDBJ | CAD83300.1 EMBL· GenBank· DDBJ | Genomic DNA |