Q7VRI8 · METE_BLOFL

  • Protein
    5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
  • Gene
    metE
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site17-205-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site1185-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site441-443L-homocysteine (UniProtKB | ChEBI)
Binding site441-443L-methionine (UniProtKB | ChEBI)
Binding site494L-homocysteine (UniProtKB | ChEBI)
Binding site494L-methionine (UniProtKB | ChEBI)
Binding site525-5265-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site5715-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site609L-homocysteine (UniProtKB | ChEBI)
Binding site609L-methionine (UniProtKB | ChEBI)
Binding site6155-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site651Zn2+ (UniProtKB | ChEBI); catalytic
Binding site653Zn2+ (UniProtKB | ChEBI); catalytic
Binding site675Zn2+ (UniProtKB | ChEBI); catalytic
Active site705Proton donor
Binding site737Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Molecular Function5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
Molecular Functionzinc ion binding
Biological Processmethionine biosynthetic process
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
  • EC number
  • Alternative names
    • Cobalamin-independent methionine synthase
    • Methionine synthase, vitamin-B12 independent isozyme

Gene names

    • Name
      metE
    • Ordered locus names
      Bfl625

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > ant endosymbionts > Candidatus Blochmanniella

Accessions

  • Primary accession
    Q7VRI8

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000986231-7695-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    769
  • Mass (Da)
    89,643
  • Last updated
    2003-10-01 v1
  • Checksum
    237481A565500CC2
MPVLSHILGFPRIGLYRELKHALEQYWEKKITENKLLDIGRMLRMRHWKQQINSGINLIPIGDFSWYDHVLDMSIMLNNIPTRFHILSQKKNTLNMLFSIARGDSINNTTITPSEMKKWFNTNYHYIVPEFVQNQIFKLNCTQLLAEIDEALSLNHPIKPVLLGPLTYLWIGKTKETKEFDRLSLLPSLLLVYKEIFNILSKKNIQWIQIDEPALVLELPQTWLKAYLHAYDQLYQTKIKLLLTTYFGKIYHQLPIIKQLKVNGLHIDLTNCSDNDISLLHEQLPKKWILSAGIINGKNIWKTNLYDWFLKLNTITHQRSLWIGSSCSLLHSPIDLNIESKLNNNIKNWFAFAIQKCSEIKLLCDALNSNHNDNSDQQNILKKYYNTNIQRLNSNIINNPQVQERCKNIITLDHSRKTKHITRMKLQHNRFNLPLYPTTTIGSFPQTSEIRKLRLKFKNKQINEDYYYTHIQQYIKKIIQEQEKLDLDILVHGEPERNDMVEYFGENLKGFVSSQHGWIQSYGSRCIKPPIIIGDISRPIPITIPWINYAQSLTNKPVKGILTGPITIMTWSFAREDIPRHMIALQLALAIRDEVMDLEKSGIGVIQIDEPALREGLPLKKSEQSYYLKWAINTFKITVSSVKDNTQIHTHMCYSEFNEIIDDILKLDVDVISIESSRSDLQLLQFIKTAGKKLNEIGPGIYDIHSIHQPSINEIMDKLKKLLQYIPKDRLWINPDCGLKTRSWNEIRESLNNMVIAAKTLRINNGLNN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX248583
EMBL· GenBank· DDBJ
CAD83300.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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