Q7VRD6 · LPXD_BLOFL

  • Protein
    UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase
  • Gene
    lpxD
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the N-acylation of UDP-3-O-(hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.

Catalytic activity

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 3/6.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site240Proton acceptor

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular FunctionN-acyltransferase activity
Molecular FunctionUDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity
Biological Processlipid A biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase
  • EC number
  • Short names
    UDP-3-O-(3-OHC14)-GlcN N-acyltransferase
  • Alternative names
    • UDP-3-O-(3-hydroxytetradecanoyl)glucosamine N-acyltransferase

Gene names

    • Name
      lpxD
    • Ordered locus names
      Bfl281

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > ant endosymbionts > Candidatus Blochmanniella

Accessions

  • Primary accession
    Q7VRD6

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000596591-369UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase

Interaction

Subunit

Homotrimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the transferase hexapeptide repeat family. LpxD subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    369
  • Mass (Da)
    39,518
  • Last updated
    2003-10-01 v1
  • MD5 Checksum
    32413A3AAA5CE2FCE3BD91D8E428702B
MAVKISLVDLAQNIGAELHGDKNILITHVSSIKNAQVGHITFLKNSRFREQLKSCAASAVILSQDNLSFCRVSALVVKNPYLAYVKVAQLLDSSPKLNANIKSQSVIHSNSILGKDVGIGYNVIIESGVIISDNVKIESGCIIGKNVKIGIGTYLWSNVTVYHGVEIGEYCIIQSGSIIGSDGFGYIKNDGVWIKIPQLGKVSIGNNVEIGSCTTIDRGTLDDTCIGDGVIIDNQCQIAHNVAIGSHTAIAGGVIIAGSVVIGKSCMIGGASVINGHIRICDKVTITGMSMVMKSITTSGIYSSGIPVQPNFAWRRTAALVMRIHSIDKRIKDIEQKVNCFFYIVIVGFFIVLGLTGLFPLIYFFVKQG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX248583
EMBL· GenBank· DDBJ
CAD83352.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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