Q7VRD6 · LPXD_BLOFL
- ProteinUDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase
- GenelpxD
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids369 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the N-acylation of UDP-3-O-(hydroxytetradecanoyl)glucosamine using 3-hydroxytetradecanoyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
Catalytic activity
- a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + a (3R)-hydroxyacyl-[ACP] = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + holo-[ACP] + H+
- UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine + (3R)-hydroxytetradecanoyl-[ACP] = UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine + holo-[ACP] + H+
Pathway
Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 3/6.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 240 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | N-acyltransferase activity | |
Molecular Function | UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity | |
Biological Process | lipid A biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase
- EC number
- Short namesUDP-3-O-(3-OHC14)-GlcN N-acyltransferase
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > ant endosymbionts > Candidatus Blochmanniella
Accessions
- Primary accessionQ7VRD6
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000059659 | 1-369 | UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase | ||
Interaction
Structure
Sequence
- Sequence statusComplete
- Length369
- Mass (Da)39,518
- Last updated2003-10-01 v1
- MD5 Checksum32413A3AAA5CE2FCE3BD91D8E428702B
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX248583 EMBL· GenBank· DDBJ | CAD83352.1 EMBL· GenBank· DDBJ | Genomic DNA |