Q7V9S8 · PANCY_PROMA
- ProteinBifunctional pantoate ligase/cytidylate kinase
- GenepanC/cmk
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids519 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
Catalyzes the transfer of a phosphate group from ATP to either CMP or dCMP to form CDP or dCDP and ADP, respectively.
Catalytic activity
- (R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H+
Pathway
Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 30-37 | ATP (UniProtKB | ChEBI) | ||||
Sequence: MGGLHQGH | ||||||
Active site | 37 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 66 | (R)-pantoate (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 66 | beta-alanine (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 155-158 | ATP (UniProtKB | ChEBI) | ||||
Sequence: GEKD | ||||||
Binding site | 161 | (R)-pantoate (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 192-195 | ATP (UniProtKB | ChEBI) | ||||
Sequence: CSSR |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | CMP kinase activity | |
Molecular Function | dCMP kinase activity | |
Molecular Function | pantoate-beta-alanine ligase activity | |
Biological Process | pantothenate biosynthetic process | |
Biological Process | pyrimidine nucleotide metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional pantoate ligase/cytidylate kinase
Including 2 domains:
- Recommended namePantothenate synthetase
- EC number
- Short namesPS
- Alternative names
- Recommended nameCytidylate kinase
- EC number
- Short namesCK
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Cyanobacteriota > Cyanophyceae > Synechococcales > Prochlorococcaceae > Prochlorococcus
Accessions
- Primary accessionQ7V9S8
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000239790 | 1-519 | Bifunctional pantoate ligase/cytidylate kinase | |||
Sequence: MNLTILRTKTALEDWCRQKHNHEINFVPTMGGLHQGHQELIKTARSFCKRKHSSQVLVSIFINPLQFDLEEDFKKYPRTFENDCKIAYEAGANAIWAPSFESVFPNGEEAHFKIQVPFSLNKYLCGASREGHFDGVATVVVRLLALVRPNRIFLGEKDWQQLVILRQLINDLGLPVLIHSIPTKRDQDGLPCSSRNVNLSKEERKKVVALPAVLQQAAQAFQENKPINLNNMKTTLEEHDLKVEYLETVDLKNLNPVNHDESKLCLLAAAVHCGNTRLIDHGFLMKRNPIVAIDGPAGAGKSTVTKKFAQKLGLIYLDTGAMYRAVTWLIQENNIDPQNSSELELILNDINLDICLSNTGNQQVLINGKDITTLIRSPTVTSQVSLVAAIGSVREKLTSQQKELGSKGGLVAEGRDIGTAVFPDAELKIFLTATAQERAKRRAIDLKKQGFSTPSLSELEKQIKERDRLDSSREIAPLSKAKDAQELITDGMNIEEVVELLINIFREKIPQEVWPTNAT |
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-282 | Pantoate--beta-alanine ligase | ||||
Sequence: MNLTILRTKTALEDWCRQKHNHEINFVPTMGGLHQGHQELIKTARSFCKRKHSSQVLVSIFINPLQFDLEEDFKKYPRTFENDCKIAYEAGANAIWAPSFESVFPNGEEAHFKIQVPFSLNKYLCGASREGHFDGVATVVVRLLALVRPNRIFLGEKDWQQLVILRQLINDLGLPVLIHSIPTKRDQDGLPCSSRNVNLSKEERKKVVALPAVLQQAAQAFQENKPINLNNMKTTLEEHDLKVEYLETVDLKNLNPVNHDESKLCLLAAAVHCGNTRLIDHG | ||||||
Region | 283-519 | Cytidylate kinase | ||||
Sequence: FLMKRNPIVAIDGPAGAGKSTVTKKFAQKLGLIYLDTGAMYRAVTWLIQENNIDPQNSSELELILNDINLDICLSNTGNQQVLINGKDITTLIRSPTVTSQVSLVAAIGSVREKLTSQQKELGSKGGLVAEGRDIGTAVFPDAELKIFLTATAQERAKRRAIDLKKQGFSTPSLSELEKQIKERDRLDSSREIAPLSKAKDAQELITDGMNIEEVVELLINIFREKIPQEVWPTNAT |
Sequence similarities
In the N-terminal section; belongs to the pantothenate synthetase family.
In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length519
- Mass (Da)58,064
- Last updated2003-10-01 v1
- Checksum268B7AFEF6EA074C
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE017126 EMBL· GenBank· DDBJ | AAQ00790.1 EMBL· GenBank· DDBJ | Genomic DNA |