Q7V735 · LAN43_PROMM
- ProteinLantipeptide prochlorosin 4.3
- GeneProcA4.3
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Lanthionine-containing peptide (lantipeptide) with unknown function (Probable). Does not show antibiotic activity against Lactococcus lactis 117 and Bacillus subtilis 6633 bacteria (By similarity).
Organisms that produce this peptide live in oligotrophic environments at very dilute concentrations, suggesting this peptide is not secreted to influence other bacteria (Probable)
Organisms that produce this peptide live in oligotrophic environments at very dilute concentrations, suggesting this peptide is not secreted to influence other bacteria (Probable)
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region |
Names & Taxonomy
Protein names
- Recommended nameLantipeptide prochlorosin 4.3
- Short namesLantipeptide Pcn4.3
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Cyanobacteriota > Cyanophyceae > Synechococcales > Prochlorococcaceae > Prochlorococcus
Accessions
- Primary accessionQ7V735
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for propeptide, modified residue, peptide, cross-link.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Propeptide | PRO_0000450377 | 1-64 | |||
Modified residue | 65 | 2,3-didehydrobutyrine | |||
Peptide | PRO_0000450378 | 65-77 | Lantipeptide prochlorosin 4.3 | ||
Cross-link | 67↔70 | Lanthionine (Ser-Cys) | |||
Cross-link | 72↔76 | Beta-methyllanthionine (Thr-Cys) | |||
Post-translational modification
Cross-links are proved in vitro, when coepressed in E.coli with the ProcM lanthionine synthetase.
The lanthionine residue has both a DL configuration (with 2S,6R stereochemistry) and a LL configuration (with 2R,6R stereochemistry) (PubMed:22574919).
DL and LL diastomers have a 4:1 ratio (PubMed:22574919).
It is unknown whether nonenzymatic cyclization occur, but authors favor a model in which ProcM does generate all thioether cross-links (Probable). The beta-methyllanthionine residue has a DL configuration (with 2S,3S,6R stereochemistry) (PubMed:22574919).
DL and LL diastomers have a 4:1 ratio (PubMed:22574919).
It is unknown whether nonenzymatic cyclization occur, but authors favor a model in which ProcM does generate all thioether cross-links (Probable). The beta-methyllanthionine residue has a DL configuration (with 2S,3S,6R stereochemistry) (PubMed:22574919).
Maturation of prochlorosin involves the enzymatic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteines. This is followed by membrane translocation and cleavage of the modified precursor.
Keywords
- PTM
Expression
Induction
Down-regulated under nitrogen starvation.
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length77
- Mass (Da)8,100
- Last updated2003-10-01 v1
- Checksum763CF6554E7C6C56
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX548175 EMBL· GenBank· DDBJ | CAE21101.1 EMBL· GenBank· DDBJ | Genomic DNA |