Q7V735 · LAN43_PROMM

Function

function

Lanthionine-containing peptide (lantipeptide) with unknown function (Probable). Does not show antibiotic activity against Lactococcus lactis 117 and Bacillus subtilis 6633 bacteria (By similarity).
Organisms that produce this peptide live in oligotrophic environments at very dilute concentrations, suggesting this peptide is not secreted to influence other bacteria (Probable)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region

Names & Taxonomy

Protein names

  • Recommended name
    Lantipeptide prochlorosin 4.3
  • Short names
    Lantipeptide Pcn4.3

Gene names

    • Name
      ProcA4.3
    • Ordered locus names
      PMT_0926

Organism names

Accessions

  • Primary accession
    Q7V735

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for propeptide, modified residue, peptide, cross-link.

Type
IDPosition(s)Description
PropeptidePRO_00004503771-64
Modified residue652,3-didehydrobutyrine
PeptidePRO_000045037865-77Lantipeptide prochlorosin 4.3
Cross-link67↔70Lanthionine (Ser-Cys)
Cross-link72↔76Beta-methyllanthionine (Thr-Cys)

Post-translational modification

Cross-links are proved in vitro, when coepressed in E.coli with the ProcM lanthionine synthetase.
The lanthionine residue has both a DL configuration (with 2S,6R stereochemistry) and a LL configuration (with 2R,6R stereochemistry) (PubMed:22574919).
DL and LL diastomers have a 4:1 ratio (PubMed:22574919).
It is unknown whether nonenzymatic cyclization occur, but authors favor a model in which ProcM does generate all thioether cross-links (Probable). The beta-methyllanthionine residue has a DL configuration (with 2S,3S,6R stereochemistry) (PubMed:22574919).
Maturation of prochlorosin involves the enzymatic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteines. This is followed by membrane translocation and cleavage of the modified precursor.

Keywords

Expression

Induction

Down-regulated under nitrogen starvation.

Structure

Family & Domains

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    77
  • Mass (Da)
    8,100
  • Last updated
    2003-10-01 v1
  • Checksum
    763CF6554E7C6C56
MSEEQLKAFIAKVQADTSLQEQLKAEGADVVAIAKAAGFTITTEDLNSHRQNLTDDELEGVAGGTASGGCDTSMFCY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX548175
EMBL· GenBank· DDBJ
CAE21101.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help