Q7V3E0 · FABH_PROMP
- ProteinBeta-ketoacyl-[acyl-carrier-protein] synthase III
- GenefabH
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids335 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
Catalytic activity
- malonyl-[ACP] + acetyl-CoA + H+ = 3-oxobutanoyl-[ACP] + CO2 + CoA
Pathway
Lipid metabolism; fatty acid biosynthesis.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 119 | ||||
Active site | 261 | ||||
Active site | 291 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 3-oxoacyl-[acyl-carrier-protein] synthase activity | |
Molecular Function | beta-ketoacyl-acyl-carrier-protein synthase III activity | |
Biological Process | fatty acid biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBeta-ketoacyl-[acyl-carrier-protein] synthase III
- EC number
- Short namesBeta-ketoacyl-ACP synthase III ; KAS III
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Cyanobacteriota > Cyanophyceae > Synechococcales > Prochlorococcaceae > Prochlorococcus
Accessions
- Primary accessionQ7V3E0
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000110454 | 1-335 | Beta-ketoacyl-[acyl-carrier-protein] synthase III | ||
Interaction
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 262-266 | ACP-binding | |||
Domain
The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.
Sequence similarities
Belongs to the thiolase-like superfamily. FabH family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length335
- Mass (Da)36,465
- Last updated2003-10-01 v1
- MD5 ChecksumA935FF8FBBB7E61A52A141B016159C32
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX548174 EMBL· GenBank· DDBJ | CAE18595.1 EMBL· GenBank· DDBJ | Genomic DNA |