Q7UG04 · MTXAW_RHOBA
- ProteinBifunctional methionine biosynthesis protein MetXA/MetW
- GenemetXA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids623 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
Catalytic activity
- acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine
Pathway
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 183 | Nucleophile | ||||
Sequence: S | ||||||
Binding site | 253 | substrate | ||||
Sequence: R | ||||||
Active site | 348 | |||||
Sequence: D | ||||||
Active site | 381 | |||||
Sequence: H | ||||||
Binding site | 382 | substrate | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | homoserine O-acetyltransferase activity | |
Biological Process | homoserine metabolic process | |
Biological Process | methionine biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional methionine biosynthesis protein MetXA/MetW
Including 2 domains:
- Recommended nameHomoserine O-acetyltransferase
- EC number
- Short namesHAT
- Alternative names
- Recommended nameProtein MetW
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Planctomycetota > Planctomycetia > Pirellulales > Pirellulaceae > Rhodopirellula
Accessions
- Primary accessionQ7UG04
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000440306 | 1-623 | Bifunctional methionine biosynthesis protein MetXA/MetW | |||
Sequence: MTSGRSTRVTMFESQASMGEPSNEDLSSTDDVRTDAPLAYAKYVTFDQSLPLERGGELPEIRCCYETWGTLNDDGSNAVLVCHAVSGDSHAARHDEDDQPGWWDGLIGPGLPIDTDRLFVVCPNVLGGCRGSTGPGDADPTSPDGKPYGANFPRITIGDIVEAQKLLADHLGIRQWRAVVGGSLGGHQVLQWINRYPDAAKTCVAIATSPRLNSQALGFDVIARNAIQTDPHYAGGQYYDKDQRPDTGLAIARMLGHITYLSVEAMEAKFDPDRHDPRQIASQFEQRFSIGSYLAHQGQKFTTRFDANSYVTLSMAMDLFDLGGTRLKLMETFDEATCDFLLISFSSDWLFPPAQSREIVNALTALDKRVTYAEITTNAGHDAFLIAKDIATYGPLIRERLRDTETHPAVPSDITLNVDEESILEIIPAGSSVLDLGCGNGQLLAAIRDRHRTPGPPTTEHRLMGVEVAQENLLATAMRGIDVIDYDLNHGLPAFIDDQFDYVILNATLQAVENVVELLNEMLRVGRHAIISFPNFAYRQLRDHYVTHGRSPKAPGEFDFDWHNTPNRRFPTIADVRDLLGQLNVVIDEEVFWDVDQGQRIEPDNDPNLNADTAVIAFHRENR |
Interaction
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-25 | Polar residues | ||||
Sequence: MTSGRSTRVTMFESQASMGEPSNED | ||||||
Region | 1-30 | Disordered | ||||
Sequence: MTSGRSTRVTMFESQASMGEPSNEDLSSTD | ||||||
Domain | 77-385 | AB hydrolase-1 | ||||
Sequence: NAVLVCHAVSGDSHAARHDEDDQPGWWDGLIGPGLPIDTDRLFVVCPNVLGGCRGSTGPGDADPTSPDGKPYGANFPRITIGDIVEAQKLLADHLGIRQWRAVVGGSLGGHQVLQWINRYPDAAKTCVAIATSPRLNSQALGFDVIARNAIQTDPHYAGGQYYDKDQRPDTGLAIARMLGHITYLSVEAMEAKFDPDRHDPRQIASQFEQRFSIGSYLAHQGQKFTTRFDANSYVTLSMAMDLFDLGGTRLKLMETFDEATCDFLLISFSSDWLFPPAQSREIVNALTALDKRVTYAEITTNAGHDAFL | ||||||
Region | 417-619 | MetW | ||||
Sequence: NVDEESILEIIPAGSSVLDLGCGNGQLLAAIRDRHRTPGPPTTEHRLMGVEVAQENLLATAMRGIDVIDYDLNHGLPAFIDDQFDYVILNATLQAVENVVELLNEMLRVGRHAIISFPNFAYRQLRDHYVTHGRSPKAPGEFDFDWHNTPNRRFPTIADVRDLLGQLNVVIDEEVFWDVDQGQRIEPDNDPNLNADTAVIAFH |
Sequence similarities
In the N-terminal section; belongs to the AB hydrolase superfamily. MetX family.
In the C-terminal section; belongs to the MetW family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length623
- Mass (Da)68,950
- Last updated2003-10-01 v1
- Checksum445E62055967CCF5
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-25 | Polar residues | ||||
Sequence: MTSGRSTRVTMFESQASMGEPSNED |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX294147 EMBL· GenBank· DDBJ | CAD78525.1 EMBL· GenBank· DDBJ | Genomic DNA |