Q7UFR2 · UVRB_RHOBA

Function

function

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site45-52ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentexcinuclease repair complex
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionDNA binding
Molecular Functionexcinuclease ABC activity
Biological Processnucleotide-excision repair
Biological ProcessSOS response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    UvrABC system protein B
  • Short names
    Protein UvrB
  • Alternative names
    • Excinuclease ABC subunit B

Gene names

    • Name
      uvrB
    • Ordered locus names
      RB8397

Organism names

Accessions

  • Primary accession
    Q7UFR2

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002260401-708UvrABC system protein B

Interaction

Subunit

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, motif, compositional bias, region.

TypeIDPosition(s)Description
Domain32-419Helicase ATP-binding
Motif98-121Beta-hairpin
Domain436-598Helicase C-terminal
Domain627-662UVR
Compositional bias668-682Basic and acidic residues
Region668-708Disordered
Compositional bias683-708Basic residues

Domain

The beta-hairpin motif is involved in DNA binding.

Sequence similarities

Belongs to the UvrB family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    708
  • Mass (Da)
    80,351
  • Last updated
    2003-10-01 v1
  • Checksum
    0A9DB5436BBCAABB
MSITKLAPAAFDLHQPFPPSGDQPAAIAKLIEGIQSGKTAQTLLGATGTGKTYTMANVIASVQRPALILSHNKTLAAQLYGEFKEFFPNNAVHYFVSYYDYYQPEAYIPQRDVYIEKDSSINEEIDRLRLATTSSLVSRRDVVIVASVSSIYGLGSPDDYRQLVVDLHQGEQTRRDHLLLKFVDLQYQRNDIQFERGKFRVRGDSIELWPSYEEFAYRIEMWGDEIEKISLIKPTSGETIKTVEHLYIYPCKHFVMPEDRIQRAIRLLREELTQQLEIFQSQGKLLEAQRLSARTKFDLEMLAEVGHCPGIENYSRPLSGKEPGATPDTLYDFFPKDFITFVDESHVTVPQVRAMYAGDRSRKITLVEHGFRLPCALDNRPLKFDEWEERTGQICFVSATPSDYELERTGGEVVEQIIRPTGLLDPEVEIVSARGQVTHLLEQVRIRAERDERVLVTALTKRLAEDLATYFQEQGVKCRWLHSELNAFERVDLLQELRAGQFDCLVGVNLLREGLDLPEVSLVAILDADKEGFLRSETSLIQTIGRAARNANSRVILYADKVTDSMQMAIDETERRRVIQMEYNAKHGIVPKTVRKSIRKGIDTEAANHKESTRKAQDSGEAIYITIEYVDKLEQEMLAAAEDLEFERAARLRDRVLQLKEHIGKPLSEVEIVDEKSAGKSGGRGRGRRGAKKKGASKGTKIPRPKRG

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias668-682Basic and acidic residues
Compositional bias683-708Basic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX294147
EMBL· GenBank· DDBJ
CAD78620.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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