Q7TT41 · MOXD2_MOUSE

  • Protein
    DBH-like monooxygenase protein 2
  • Gene
    Moxd2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

Cofactor

Cu2+ (UniProtKB | Rhea| CHEBI:29036 )

Note: Binds 2 copper ions per subunit.

Features

Showing features for active site, binding site.

161950100150200250300350400450500550600
TypeIDPosition(s)Description
Active site209
Binding site241Cu cation A (UniProtKB | ChEBI)
Binding site242Cu cation A (UniProtKB | ChEBI)
Binding site309Cu cation A (UniProtKB | ChEBI)
Active site390
Binding site390Cu cation B (UniProtKB | ChEBI)
Binding site392Cu cation B (UniProtKB | ChEBI)
Binding site465Cu cation B (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentextracellular space
Cellular Componentsecretory granule membrane
Molecular Functioncopper ion binding
Molecular Functiondopamine beta-monooxygenase activity
Biological Processdopamine catabolic process
Biological Processnorepinephrine biosynthetic process
Biological Processoctopamine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DBH-like monooxygenase protein 2
  • EC number
  • Alternative names
    • Dopamine-beta-hydroxylase-like protein

Gene names

    • Name
      Moxd2
    • Synonyms
      Dbhl, Dbhl1

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q7TT41
  • Secondary accessions
    • Q91XT2

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain22-594Extracellular
Transmembrane595-615Helical
Topological domain616-619Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_000030522422-619DBH-like monooxygenase protein 2
Disulfide bond211↔261
Disulfide bond248↔271
Glycosylation250N-linked (GlcNAc...) asparagine
Disulfide bond366↔481
Glycosylation405N-linked (GlcNAc...) asparagine
Disulfide bond444↔466
Glycosylation477N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed at low levels in thymus and testis.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain40-156DOMON

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    619
  • Mass (Da)
    69,397
  • Last updated
    2003-10-01 v1
  • Checksum
    74518832AD5E1A63
MACVLLFRLFLLLVLAAFSQGKRLGPTSPLRYSRFLDPSRAVFLRWDFDYEAEIITFELQVQTTGWVGLGITDRYTFVGSDLVVGGVLPNGNVYFSDQHLLDEDTLEQDGSQDAELLRLTEDAVSTTMRFSRPFRTCDPHDRDITSDTMRVLAAYGPDDIPKMSREHTFVKSIFLLQMLQYDDQDAPEDTIIHDLKISNFIIPEDDTTYACTFLPLPIVSKKHHIYKFEPILVERNETMVHHVLVYACGNSSVLPTGIGECYGSDPAFSLCSHVIAGWAVGGLSYQFPDDVGISIGTPFDPQWIRLEIHYSNFQNLPGIRDTSGMRLFYTSHLRKYDMGVLQLGISVFPIHFIPPGAEAFLSYGLCKTDKFEELNGAPVSDIYISACLLHTHLAGRSLQALQYRNGTQLQVVCKDFSYDFNLQESRDLPHPVVIKPGDELLIECHYQTLDRDFMTFGGASTINEMCLIFFFYYPRINISSCMGYPDIIYVTNELGEEASENPMENLMVLDNVEWTPENIKKAEKACKESQQTVLIKTIDEEVENTTGWIPDIIPTPRGPCLESTGGKVEPQDNTPAGFRAVPLALSGSNTATLRPLPMIAVLFLQGSLSCLLAMLQTGV

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict289in Ref. 2; BAB62024
Sequence conflict561in Ref. 2; BAB62024

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE000663
EMBL· GenBank· DDBJ
AAB69054.1
EMBL· GenBank· DDBJ
Genomic DNA
AB065134
EMBL· GenBank· DDBJ
BAB62024.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp