Q7TSI0 · ZNF12_MOUSE

  • Protein
    Zinc finger protein 12
  • Gene
    Znf12
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Transcriptional repressor which suppresses activation protein 1 (AP-1)- and serum response element (SRE)-mediated transcriptional activity.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcentrosome
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Functionmetal ion binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processnegative regulation of DNA-templated transcription
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Zinc finger protein 12

Gene names

    • Name
      Znf12
    • Synonyms
      Zfp12

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q7TSI0
  • Secondary accessions
    • Q8C7Q7

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, cross-link.

TypeIDPosition(s)Description
ChainPRO_00004028331-686Zinc finger protein 12
Cross-link173Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Cross-link203Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Cross-link218Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Cross-link261Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Cross-link303Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Cross-link317Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Cross-link331Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Cross-link359Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Cross-link541Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias, zinc finger.

TypeIDPosition(s)Description
Domain8-79KRAB
Region90-129Disordered
Compositional bias95-113Polar residues
Region174-198Disordered
Zinc finger263-285C2H2-type 1
Zinc finger291-313C2H2-type 2
Zinc finger319-341C2H2-type 3
Zinc finger347-369C2H2-type 4
Zinc finger375-397C2H2-type 5
Zinc finger403-425C2H2-type 6
Zinc finger431-453C2H2-type 7
Zinc finger459-481C2H2-type 8
Zinc finger487-509C2H2-type 9
Zinc finger515-537C2H2-type 10
Zinc finger543-565C2H2-type 11
Zinc finger571-593C2H2-type 12
Zinc finger599-621C2H2-type 13
Zinc finger627-649C2H2-type 14
Zinc finger655-677C2H2-type 15

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q7TSI0-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    686
  • Mass (Da)
    78,617
  • Last updated
    2003-10-01 v1
  • Checksum
    A391CBF8D69FE3E4
MNTSLGPLSFKDVAVAFSQEEWQQLDPEERTTYRDVMLETYSNLVSVGYDIIKPDVIIKLEQGEEPWIVEGAFSPQSYPDEIRHMSRLMEEDQGGEENQSSSAVFSYRSRADASSKATDGETKPFPSQKALPQCNSCEKSLMCVSAFIRSDGSYAKLRPNVCAGCGKPLPCSKPEETHPGGESYEFSGDGDEDPLGEEGVYQKGHFLEEPFEYVECQKSFPKGTVFLNHLEEEPCDWNDAEVAFLQTSDLSAHQDSLMEMKPYECQQCGKSFCKKSKFVIHQRTHTGEKPFKCSQCGKSFCQKGTLTVHQRTHTGEKPYECTECGKTFYQKLHLIQHQRTHSGEKPYKCGYCGKSFCQKTHLTQHQRTHSGERPYVCHDCGKTFSQKSALNDHQKIHTGVKLYKCSECGKCFCRKSTLTTHMRTHTGEKPYECNECGKFFSRLSYLTVHYRTHSGEKPYECAECGKSFYLNSALMRHQRVHTGEKPYECNECGKLFSQLSYLTVHHRTHSGVKPYECSECGKTFYQNSALCRHRRIHRGEKPYECYICGKFFSQMSYLTIHHRIHSGEKPYECRECGKSFCQNSALNRHQRTHTGEKAYECYECGKCFSQMSYLTIHHRIHSGEKPFECNECGKAFSRMSYLTVHHRTHSGEKPYECTECGKKFYHKSAFNSHQRTHRRGSGNGVD

Q7TSI0-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
M0QWS1M0QWS1_MOUSEZfp1272
E0CYZ8E0CYZ8_MOUSEZfp1247

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_04033648-79in isoform 2
Compositional bias95-113Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK049650
EMBL· GenBank· DDBJ
BAC33859.1
EMBL· GenBank· DDBJ
mRNA
CH466529
EMBL· GenBank· DDBJ
EDL19061.1
EMBL· GenBank· DDBJ
Genomic DNA
CH466529
EMBL· GenBank· DDBJ
EDL19062.1
EMBL· GenBank· DDBJ
Genomic DNA
BC053080
EMBL· GenBank· DDBJ
AAH53080.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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