Q7TSG1 · CE120_MOUSE

  • Protein
    Centrosomal protein of 120 kDa
  • Gene
    Cep120
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcentriole
Cellular Componentcentrosome
Cellular Componentcytoplasm
Biological Processastral microtubule organization
Biological Processcell population proliferation
Biological Processcentrosome cycle
Biological Processcerebral cortex development
Biological Processinterkinetic nuclear migration
Biological Processmicrotubule cytoskeleton organization
Biological Processneurogenesis
Biological Processpositive regulation of centriole elongation
Biological Processpositive regulation of centrosome duplication
Biological Processpositive regulation of cilium assembly
Biological Processpositive regulation of establishment of protein localization
Biological Processregulation of microtubule-based process
Biological Processregulation of protein localization

Names & Taxonomy

Protein names

  • Recommended name
    Centrosomal protein of 120 kDa
  • Short names
    Cep120
  • Alternative names
    • Coiled-coil domain-containing protein 100

Gene names

    • Name
      Cep120
    • Synonyms
      Ccdc100

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q7TSG1
  • Secondary accessions
    • Q80Y93
    • Q80ZQ2
    • Q8BG01
    • Q8C580
    • Q8C8B6
    • Q8CAF2

Proteomes

Organism-specific databases

Subcellular Location

Note: Regulates the localization of TACC3 to the centrosome in neural progenitors in vivo.

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00003482631-988Centrosomal protein of 120 kDa
Modified residue934Phosphoserine
Modified residue938Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Ubiquitous. Highly expressed in brain, lung and kidney and weakly expressed in heart, liver, small intestine and limb (at protein level). Expressed in brain.

Developmental stage

Expressed in embryonic brain from 10.5 to 17.5 dpc. Expressed in neocortical neural progenitors at the ventrical surface at 12.5 dpc (at protein level). Expressed in brain, heart, lung, liver, kidney, small intestine and limb at 16.5 dpc.

Gene expression databases

Interaction

Subunit

Interacts with TACC2, TACC3, CCDC52, TALPID3.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q7TSG1Talpid3 E9PV873EBI-2553947, EBI-11692182

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain, compositional bias, region, coiled coil.

TypeIDPosition(s)Description
Domain1-112C2 1
Compositional bias354-368Basic and acidic residues
Region354-425Disordered
Compositional bias381-396Pro residues
Compositional bias400-414Basic and acidic residues
Domain435-569C2 2
Region624-644Disordered
Coiled coil706-929

Sequence similarities

Belongs to the CEP120 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing.

Q7TSG1-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    988
  • Mass (Da)
    112,579
  • Last updated
    2003-10-01 v1
  • Checksum
    AF9A80D682A93953
MVPKSDQLLIVVSILEGRHFPKRPKHLLVVEAKFDGEQLATDPVDHTDQPEFATELAWEIDRKVLHQHRLQRTPIKLQCFALDPQTSAKETVGYIVLDLRTAQETKQAPKWYQLLSNKYTKFKAEVQISLTLETDTKAQVDSYKAKAAPPRDGKVLASLAGVDPKDIVAVLNEEGGYHQIGPAEHCTDPFILSVTIAFATQLEQLIPCTMKLPERQPEFFFYYSLLGNDVTNEPFSDLINPNFEPERASVRIRSSVEILRVYLALHSKLQIHLCCGDQSLGSTEIPLNGLLKKGSTEINQHPVTVEGAFTLDPPNRAKQKLAPVPLDLAPTVGVSVALQREGIDSQSLIELKTQNGHEAEHSQKRVLTPIKEKTLTGPKSPRESPAPPPPPNQTPPTKDDATESEVESLQYDKDPKPTVKGIGSVPASLAQPEATCGASEVVTSGQKIAVPAASHHFCFSVDLRSVHDLELSFPVNCILRYSYPFFGSAAPIMTNPPVEVRKNMEVFLPQSYCAFDFATMPHQLQDTFLRIPLLVELWHKDKMSKDLLLGVARIQLSNILSSEKTRFLGANGEQCWRQTYSESVPVIAAQGSNNRILDLSYTMTLEDYGLVKMREIFVSESSQGVPAVDQKPSSPPPAPCPSEIQMEPRETLEYKAALELEMWKEMQEDIFESQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYSILEGKLQKALTELETREQQLASAEAELQRERKELQLERERNLQELQDSVRRARDDCVYQVELERLKLKQLEEDKQRLQQQLNDAGNKYKTLEKEFQQFKDQQNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQESQMARLKKQQEELEQMRLRYLAAEEKETVRTEQQELLDIRNELNRLRQQEQNQYQDCKEIASGKLGSPRGSGLEEGLDDYLTRLIEERDTLMRTGVYNHEDRIISELDRQIREVLTKNSAS

Q7TSG1-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 913-988: LRQQEQNQYQDCKEIASGKLGSPRGSGLEEGLDDYLTRLIEERDTLMRTGVYNHEDRIISELDRQIREVLTKNSAS → YCPYNHSFSHQHRSDSQ

Q7TSG1-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 347-365: SLIELKTQNGHEAEHSQKR → AGGDSAFTCQFSHARDDKR
    • 366-988: Missing

Q7TSG1-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for alternative sequence, compositional bias, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0351261-901in isoform 4
Alternative sequenceVSP_035127347-365in isoform 3
Compositional bias354-368Basic and acidic residues
Alternative sequenceVSP_035128366-988in isoform 3
Compositional bias381-396Pro residues
Compositional bias400-414Basic and acidic residues
Sequence conflict614in Ref. 1; BAC33092
Alternative sequenceVSP_035129902-911in isoform 4
Alternative sequenceVSP_035130913-988in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK038916
EMBL· GenBank· DDBJ
BAC30167.1
EMBL· GenBank· DDBJ
mRNA
AK044808
EMBL· GenBank· DDBJ
BAC32100.1
EMBL· GenBank· DDBJ
mRNA
AK044952
EMBL· GenBank· DDBJ
BAC32156.1
EMBL· GenBank· DDBJ
mRNA
AK047594
EMBL· GenBank· DDBJ
BAC33092.1
EMBL· GenBank· DDBJ
mRNA
AK079319
EMBL· GenBank· DDBJ
BAC37606.1
EMBL· GenBank· DDBJ
mRNA
BC046493
EMBL· GenBank· DDBJ
AAH46493.1
EMBL· GenBank· DDBJ
mRNA
BC048590
EMBL· GenBank· DDBJ
AAH48590.1
EMBL· GenBank· DDBJ
mRNA
BC053439
EMBL· GenBank· DDBJ
AAH53439.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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