Q7TSG1 · CE120_MOUSE
- ProteinCentrosomal protein of 120 kDa
- GeneCep120
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids988 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. Required for centriole duplication and maturation during mitosis and subsequent ciliogenesis. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | centriole | |
Cellular Component | centrosome | |
Cellular Component | cytoplasm | |
Biological Process | astral microtubule organization | |
Biological Process | cell population proliferation | |
Biological Process | centrosome cycle | |
Biological Process | cerebral cortex development | |
Biological Process | interkinetic nuclear migration | |
Biological Process | microtubule cytoskeleton organization | |
Biological Process | neurogenesis | |
Biological Process | positive regulation of centriole elongation | |
Biological Process | positive regulation of centrosome duplication | |
Biological Process | positive regulation of cilium assembly | |
Biological Process | positive regulation of establishment of protein localization | |
Biological Process | regulation of microtubule-based process | |
Biological Process | regulation of protein localization |
Names & Taxonomy
Protein names
- Recommended nameCentrosomal protein of 120 kDa
- Short namesCep120
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ7TSG1
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Regulates the localization of TACC3 to the centrosome in neural progenitors in vivo.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000348263 | 1-988 | Centrosomal protein of 120 kDa | |||
Sequence: MVPKSDQLLIVVSILEGRHFPKRPKHLLVVEAKFDGEQLATDPVDHTDQPEFATELAWEIDRKVLHQHRLQRTPIKLQCFALDPQTSAKETVGYIVLDLRTAQETKQAPKWYQLLSNKYTKFKAEVQISLTLETDTKAQVDSYKAKAAPPRDGKVLASLAGVDPKDIVAVLNEEGGYHQIGPAEHCTDPFILSVTIAFATQLEQLIPCTMKLPERQPEFFFYYSLLGNDVTNEPFSDLINPNFEPERASVRIRSSVEILRVYLALHSKLQIHLCCGDQSLGSTEIPLNGLLKKGSTEINQHPVTVEGAFTLDPPNRAKQKLAPVPLDLAPTVGVSVALQREGIDSQSLIELKTQNGHEAEHSQKRVLTPIKEKTLTGPKSPRESPAPPPPPNQTPPTKDDATESEVESLQYDKDPKPTVKGIGSVPASLAQPEATCGASEVVTSGQKIAVPAASHHFCFSVDLRSVHDLELSFPVNCILRYSYPFFGSAAPIMTNPPVEVRKNMEVFLPQSYCAFDFATMPHQLQDTFLRIPLLVELWHKDKMSKDLLLGVARIQLSNILSSEKTRFLGANGEQCWRQTYSESVPVIAAQGSNNRILDLSYTMTLEDYGLVKMREIFVSESSQGVPAVDQKPSSPPPAPCPSEIQMEPRETLEYKAALELEMWKEMQEDIFESQLKQKELAHMQALAEEWKKRDRERESLVKKKVAEYSILEGKLQKALTELETREQQLASAEAELQRERKELQLERERNLQELQDSVRRARDDCVYQVELERLKLKQLEEDKQRLQQQLNDAGNKYKTLEKEFQQFKDQQNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQESQMARLKKQQEELEQMRLRYLAAEEKETVRTEQQELLDIRNELNRLRQQEQNQYQDCKEIASGKLGSPRGSGLEEGLDDYLTRLIEERDTLMRTGVYNHEDRIISELDRQIREVLTKNSAS | ||||||
Modified residue | 934 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 938 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Ubiquitous. Highly expressed in brain, lung and kidney and weakly expressed in heart, liver, small intestine and limb (at protein level). Expressed in brain.
Developmental stage
Expressed in embryonic brain from 10.5 to 17.5 dpc. Expressed in neocortical neural progenitors at the ventrical surface at 12.5 dpc (at protein level). Expressed in brain, heart, lung, liver, kidney, small intestine and limb at 16.5 dpc.
Gene expression databases
Interaction
Subunit
Interacts with TACC2, TACC3, CCDC52, TALPID3.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q7TSG1 | Talpid3 E9PV87 | 3 | EBI-2553947, EBI-11692182 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-112 | C2 1 | ||||
Sequence: MVPKSDQLLIVVSILEGRHFPKRPKHLLVVEAKFDGEQLATDPVDHTDQPEFATELAWEIDRKVLHQHRLQRTPIKLQCFALDPQTSAKETVGYIVLDLRTAQETKQAPKWY | ||||||
Compositional bias | 354-368 | Basic and acidic residues | ||||
Sequence: QNGHEAEHSQKRVLT | ||||||
Region | 354-425 | Disordered | ||||
Sequence: QNGHEAEHSQKRVLTPIKEKTLTGPKSPRESPAPPPPPNQTPPTKDDATESEVESLQYDKDPKPTVKGIGSV | ||||||
Compositional bias | 381-396 | Pro residues | ||||
Sequence: PRESPAPPPPPNQTPP | ||||||
Compositional bias | 400-414 | Basic and acidic residues | ||||
Sequence: DATESEVESLQYDKD | ||||||
Domain | 435-569 | C2 2 | ||||
Sequence: TCGASEVVTSGQKIAVPAASHHFCFSVDLRSVHDLELSFPVNCILRYSYPFFGSAAPIMTNPPVEVRKNMEVFLPQSYCAFDFATMPHQLQDTFLRIPLLVELWHKDKMSKDLLLGVARIQLSNILSSEKTRFLG | ||||||
Region | 624-644 | Disordered | ||||
Sequence: GVPAVDQKPSSPPPAPCPSEI | ||||||
Coiled coil | 706-929 | |||||
Sequence: AEYSILEGKLQKALTELETREQQLASAEAELQRERKELQLERERNLQELQDSVRRARDDCVYQVELERLKLKQLEEDKQRLQQQLNDAGNKYKTLEKEFQQFKDQQNNKPEIRLQSEINLLTLEKVELERKLESATKSKLHYKQQWGRALKELARLKQREQESQMARLKKQQEELEQMRLRYLAAEEKETVRTEQQELLDIRNELNRLRQQEQNQYQDCKEIAS |
Sequence similarities
Belongs to the CEP120 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 4 isoforms produced by Alternative splicing.
Q7TSG1-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length988
- Mass (Da)112,579
- Last updated2003-10-01 v1
- ChecksumAF9A80D682A93953
Q7TSG1-2
- Name2
- Differences from canonical
- 913-988: LRQQEQNQYQDCKEIASGKLGSPRGSGLEEGLDDYLTRLIEERDTLMRTGVYNHEDRIISELDRQIREVLTKNSAS → YCPYNHSFSHQHRSDSQ
Q7TSG1-3
- Name3
Q7TSG1-4
- Name4
Features
Showing features for alternative sequence, compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_035126 | 1-901 | in isoform 4 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_035127 | 347-365 | in isoform 3 | |||
Sequence: SLIELKTQNGHEAEHSQKR → AGGDSAFTCQFSHARDDKR | ||||||
Compositional bias | 354-368 | Basic and acidic residues | ||||
Sequence: QNGHEAEHSQKRVLT | ||||||
Alternative sequence | VSP_035128 | 366-988 | in isoform 3 | |||
Sequence: Missing | ||||||
Compositional bias | 381-396 | Pro residues | ||||
Sequence: PRESPAPPPPPNQTPP | ||||||
Compositional bias | 400-414 | Basic and acidic residues | ||||
Sequence: DATESEVESLQYDKD | ||||||
Sequence conflict | 614 | in Ref. 1; BAC33092 | ||||
Sequence: R → G | ||||||
Alternative sequence | VSP_035129 | 902-911 | in isoform 4 | |||
Sequence: ELLDIRNELN → MNLLRRSLHP | ||||||
Alternative sequence | VSP_035130 | 913-988 | in isoform 2 | |||
Sequence: LRQQEQNQYQDCKEIASGKLGSPRGSGLEEGLDDYLTRLIEERDTLMRTGVYNHEDRIISELDRQIREVLTKNSAS → YCPYNHSFSHQHRSDSQ |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK038916 EMBL· GenBank· DDBJ | BAC30167.1 EMBL· GenBank· DDBJ | mRNA | ||
AK044808 EMBL· GenBank· DDBJ | BAC32100.1 EMBL· GenBank· DDBJ | mRNA | ||
AK044952 EMBL· GenBank· DDBJ | BAC32156.1 EMBL· GenBank· DDBJ | mRNA | ||
AK047594 EMBL· GenBank· DDBJ | BAC33092.1 EMBL· GenBank· DDBJ | mRNA | ||
AK079319 EMBL· GenBank· DDBJ | BAC37606.1 EMBL· GenBank· DDBJ | mRNA | ||
BC046493 EMBL· GenBank· DDBJ | AAH46493.1 EMBL· GenBank· DDBJ | mRNA | ||
BC048590 EMBL· GenBank· DDBJ | AAH48590.1 EMBL· GenBank· DDBJ | mRNA | ||
BC053439 EMBL· GenBank· DDBJ | AAH53439.1 EMBL· GenBank· DDBJ | mRNA |