Q7TSD4 · TBATA_MOUSE
- ProteinProtein TBATA
- GeneTbata
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids393 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Isoform 1 and isoform 2 may play a role in spermatid differentiation. Isoform 1 and isoform 2 regulate thymus function by modulating stromal cell proliferation via interference with the NEDD8 pathway.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Biological Process | spermatid differentiation |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameProtein TBATA
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ7TSD4
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Isoform 1
Note: Located throughout the cytosol of early round spermatids. By the end stages of round spermatid development, concentrated at the side of the cell near the nascent flagellum and in the manchette. In mature sperm, located in the principle piece of the tail.
Isoform 2
Note: Located throughout the cytosol of early round spermatids. By the end stages of round spermatid development, concentrated at the side of the cell near the nascent flagellum and in the manchette. In mature sperm, located in the principle piece of the tail.
Isoform 6
Isoform 7
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000351147 | 1-393 | Protein TBATA | ||
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in the subcapsular region of the thymus and lymph node (at protein level). Highly expressed in thymic cortical stromal cells and testis. Lower levels found in brain cortex, hippocampus, kidney, cerebellum, skeletal muscle, epididymis and ovary. No expression detected in other lymphoid organs including bone marrow and spleen. Isoform 1 and isoform 2 are expressed predominantly in testis. Isoform 3, isoform 4 and isoform 5 are expressed predominantly in thymus although isoform 3 is also expressed in testis. In the CNS, highly expressed in restricted areas, the cerebellum and hippocampus.
Induction
Up-regulated in aged mice (4 months of age or older).
Developmental stage
In testis, isoform 1 and isoform 2 are expressed only in the adult from postnatal week 7. Expression is detected in pachytene spermatocytes, increases greatly in round spermatids and is very strong in round/elongating and elongating spermatids. Expression is reduced in condensed spermatids and persists in spermatozoa. Isoform 3 is specifically expressed in round spermatids and is greatly reduced in spermatids under maturation (at protein level). Isoform 7 is detected in the embryo from day 10 while isoform 7 is not detected until day 12. In brain, predominantly expressed by granule cells during cerebellar development. Isoform 1 and isoform 3 are differentially expressed during cerebellar development.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-39 | Disordered | |||
Region | 168-188 | Disordered | |||
Compositional bias | 169-185 | Polar residues | |||
Region | 202-264 | Disordered | |||
Compositional bias | 204-222 | Basic and acidic residues | |||
Compositional bias | 236-264 | Polar residues | |||
Region | 340-393 | Disordered | |||
Compositional bias | 379-393 | Basic and acidic residues | |||
Sequence similarities
Belongs to the TBATA family.
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 8 isoforms produced by Alternative splicing.
Q7TSD4-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsEpsilon
- Length393
- Mass (Da)43,842
- Last updated2008-09-23 v2
- ChecksumED5BB0126B6A6947
Q7TSD4-2
- Name2
- SynonymsDelta
- Differences from canonical
- 98-131: Missing
Q7TSD4-3
- Name3
- SynonymsBeta
Q7TSD4-4
- Name4
- SynonymsAlpha
Q7TSD4-5
- Name5
- SynonymsGamma
Q7TSD4-6
- Name6
Q7TSD4-7
- Name7
Q7TSD4-8
- Name8
- SynonymsZeta
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1W2P7K0 | A0A1W2P7K0_MOUSE | Tbata | 64 | ||
A0A1W2P6T4 | A0A1W2P6T4_MOUSE | Tbata | 100 | ||
A0A1W2P7P7 | A0A1W2P7P7_MOUSE | Tbata | 66 | ||
A0A1W2P839 | A0A1W2P839_MOUSE | Tbata | 102 | ||
D6RH51 | D6RH51_MOUSE | Tbata | 166 | ||
F6RYN6 | F6RYN6_MOUSE | Tbata | 157 |
Sequence caution
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Alternative sequence | VSP_052935 | 1-14 | in isoform 3, isoform 4, isoform 6, isoform 7 and isoform 8 | ||
Alternative sequence | VSP_052937 | 98-131 | in isoform 2, isoform 3, isoform 5 and isoform 7 | ||
Alternative sequence | VSP_052936 | 98-166 | in isoform 8 | ||
Alternative sequence | VSP_052938 | 167-393 | in isoform 8 | ||
Compositional bias | 169-185 | Polar residues | |||
Alternative sequence | VSP_052939 | 184 | in isoform 4 | ||
Alternative sequence | VSP_052940 | 185 | in isoform 3 | ||
Compositional bias | 204-222 | Basic and acidic residues | |||
Alternative sequence | VSP_052941 | 212-226 | in isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7 | ||
Alternative sequence | VSP_052942 | 227-393 | in isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7 | ||
Compositional bias | 236-264 | Polar residues | |||
Compositional bias | 379-393 | Basic and acidic residues | |||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF257502 EMBL· GenBank· DDBJ | AAG37103.1 EMBL· GenBank· DDBJ | mRNA | ||
AF257503 EMBL· GenBank· DDBJ | AAG37104.1 EMBL· GenBank· DDBJ | mRNA | ||
AF521591 EMBL· GenBank· DDBJ | AAP50907.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AF521592 EMBL· GenBank· DDBJ | AAP50908.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AY243457 EMBL· GenBank· DDBJ | AAP41210.2 EMBL· GenBank· DDBJ | mRNA | ||
AY243458 EMBL· GenBank· DDBJ | AAP41211.1 EMBL· GenBank· DDBJ | mRNA | Frameshift | |
AY243459 EMBL· GenBank· DDBJ | AAP41212.1 EMBL· GenBank· DDBJ | mRNA | ||
EU622858 EMBL· GenBank· DDBJ | ACD01420.1 EMBL· GenBank· DDBJ | mRNA | ||
AK038284 EMBL· GenBank· DDBJ | BAC29958.1 EMBL· GenBank· DDBJ | mRNA |