Q7TS63 · ZFAT_MOUSE
- ProteinZinc finger protein ZFAT
- GeneZfat
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1237 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 273 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 276 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 289 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 293 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 301 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 304 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 317 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 321 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 328 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 331 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 344 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 349 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 356 | Zn2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 359 | Zn2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 372 | Zn2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 377 | Zn2+ 4 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 406 | Zn2+ 5 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 409 | Zn2+ 5 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 422 | Zn2+ 5 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 426 | Zn2+ 5 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 460 | Zn2+ 6 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 463 | Zn2+ 6 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 476 | Zn2+ 6 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 481 | Zn2+ 6 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 767 | Zn2+ 7 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 770 | Zn2+ 7 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 783 | Zn2+ 7 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 788 | Zn2+ 7 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 795 | Zn2+ 8 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 800 | Zn2+ 8 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 813 | Zn2+ 8 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 817 | Zn2+ 8 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 827 | Zn2+ 9 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 830 | Zn2+ 9 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 843 | Zn2+ 9 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 848 | Zn2+ 9 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 877 | Zn2+ 10 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 880 | Zn2+ 10 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 894 | Zn2+ 10 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 898 | Zn2+ 10 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 906 | Zn2+ 11 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 909 | Zn2+ 11 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 922 | Zn2+ 11 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 926 | Zn2+ 11 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 934 | Zn2+ 12 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 937 | Zn2+ 12 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 950 | Zn2+ 12 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 953 | Zn2+ 12 (UniProtKB | ChEBI) | ||||
Sequence: L |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription activator activity, RNA polymerase II-specific | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | hematopoietic progenitor cell differentiation | |
Biological Process | hemopoiesis | |
Biological Process | regulation of DNA-templated transcription | |
Biological Process | spongiotrophoblast layer development |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameZinc finger protein ZFAT
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ7TS63
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000047567 | 1-1237 | Zinc finger protein ZFAT | |||
Sequence: METRTAENTAIFMCKCCNLFSPNQSELVTHVSEKHGEEGVNVDDVIIPLRPLNTPENPNPSKGGDEFLVMKRKRGRPKGSTKKPSTEEEVVENLVSPSEDGPLATEEGSRLAPSSLECSKCCRKFSNTRQLRKHICIIVLNLGEEDGDAGNESDLDLEKTYKEDDREKASKRPRAQKTEKVQKISGKEAGQLSGAKKPIISVVLTAHEAIPGATKIIPVEAGPPETGAPPPETTAADLVPRRGYQEYAIQQTPYEQPMKSSRLGPTQLKIFTCEYCNKVFKFKHSLQAHLRIHTNEKPYKCSQCSYASAIKANLNVHLRKHTGEKFACDYCSFTCLSKGHLKVHIERVHKKIKQHCRFCKKKYSDVKNLIKHIRDMHDPQDKKVKEALDELRLMTREGKRQLLYDCHICERKFKNELDRDRHMLVHGDKWPFACELCGHGATKYQALELHVRKHPFVYVCALCLKKFVSSIRLRSHIREVHGAAQETLVFTSSINQSFCLLEPGGDIQQEALGDQLQLAAEEFVCPEIDVRKEEACPGEAQPEVGLRELVVPGDAHAPPPGPLATPQSESSSLSPCKLETTVVSSDLNSLGVVSDDFLLKSDTSSAEPPAAAEATSDTQHRDSAQTQGEEVTLLLAKAKSAGPDPESSPGGRQKVGALPASESDSSTCLRANPTEASDLLPTVTDGGDLGVCQPDSCTPSSEHHPGSTAFMKVLDSLQKKQMNTSLCERIRKVYGDLECEYCGKLFWYQVHFDMHVRTHTREHLYYCSQCHYSSITKNCLKRHVIQKHSNILLKCPTDGCDYSTPDKYKLQAHLKVHTELDKRSYSCPVCEKSFSEDRLIKSHIKTNHPEVSMNTISEVLGRRVQLKGLIGKRAMKCPYCDFYFMKNGSDLQRHIWAHEGVKPFKCSLCEYATRSKSNLKAHMNRHSTEKTHLCDMCGKKFKSKGTLKSHKLLHTSDGKQFKCTVCDYTAAQKPQLLRHMEQHASFKPFRCAHCHYSCNISGSLKRHYNRKHPNEEYTNVGSGELAAEALIQQGGLKCPVCSFVYGTKWEFNRHLKNKHGLKVVEIDGDPKWEPAAETPEEPSTQYLYITEAEDVQGTQAAVAALQDLRYTSESGDRLDPTAVNILQQIIELGSETHDAAAVASVVAMAPGTVTVVKQVTDEEPSSNHTVMIQETLQQASVELAEQHHLVVSSDDVEGIETVTVYTQGGEASEFIVYVQEAVQPVEEQVGEQPAPEL |
Proteomic databases
PTM databases
Expression
Tissue specificity
Detected in spleen and thymus but not in liver, muscle, heart, kidney, brain, bone marrow or pancreas. Expressed in CD19+, CD4+ and CD8+ lymphocytes but not in CD11b+ lymphocytes or peritoneal macrophages (at protein level).
Developmental stage
Up-regulated during the transition from CD4-/CD8- to CD4+/CD8+ thymocytes.
Gene expression databases
Structure
Family & Domains
Features
Showing features for zinc finger, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Zinc finger | 12-35 | C2H2-type 1 | ||||
Sequence: FMCKCCNLFSPNQSELVTHVSEKH | ||||||
Region | 50-110 | Disordered | ||||
Sequence: RPLNTPENPNPSKGGDEFLVMKRKRGRPKGSTKKPSTEEEVVENLVSPSEDGPLATEEGSR | ||||||
Zinc finger | 116-141 | C2H2-type 2; degenerate | ||||
Sequence: LECSKCCRKFSNTRQLRKHICIIVLN | ||||||
Region | 147-188 | Disordered | ||||
Sequence: GDAGNESDLDLEKTYKEDDREKASKRPRAQKTEKVQKISGKE | ||||||
Compositional bias | 153-184 | Basic and acidic residues | ||||
Sequence: SDLDLEKTYKEDDREKASKRPRAQKTEKVQKI | ||||||
Zinc finger | 271-293 | C2H2-type 3 | ||||
Sequence: FTCEYCNKVFKFKHSLQAHLRIH | ||||||
Zinc finger | 299-321 | C2H2-type 4 | ||||
Sequence: YKCSQCSYASAIKANLNVHLRKH | ||||||
Zinc finger | 326-349 | C2H2-type 5 | ||||
Sequence: FACDYCSFTCLSKGHLKVHIERVH | ||||||
Zinc finger | 354-377 | C2H2-type 6 | ||||
Sequence: QHCRFCKKKYSDVKNLIKHIRDMH | ||||||
Zinc finger | 404-426 | C2H2-type 7 | ||||
Sequence: YDCHICERKFKNELDRDRHMLVH | ||||||
Zinc finger | 432-454 | C2H2-type 8 | ||||
Sequence: FACELCGHGATKYQALELHVRKH | ||||||
Zinc finger | 458-481 | C2H2-type 9 | ||||
Sequence: YVCALCLKKFVSSIRLRSHIREVH | ||||||
Region | 551-576 | Disordered | ||||
Sequence: VPGDAHAPPPGPLATPQSESSSLSPC | ||||||
Region | 601-671 | Disordered | ||||
Sequence: SDTSSAEPPAAAEATSDTQHRDSAQTQGEEVTLLLAKAKSAGPDPESSPGGRQKVGALPASESDSSTCLRA | ||||||
Compositional bias | 608-630 | Polar residues | ||||
Sequence: PPAAAEATSDTQHRDSAQTQGEE | ||||||
Zinc finger | 737-759 | C2H2-type 10 | ||||
Sequence: LECEYCGKLFWYQVHFDMHVRTH | ||||||
Zinc finger | 765-788 | C2H2-type 11 | ||||
Sequence: YYCSQCHYSSITKNCLKRHVIQKH | ||||||
Zinc finger | 793-817 | C2H2-type 12 | ||||
Sequence: LKCPTDGCDYSTPDKYKLQAHLKVH | ||||||
Zinc finger | 825-848 | C2H2-type 13 | ||||
Sequence: YSCPVCEKSFSEDRLIKSHIKTNH | ||||||
Zinc finger | 875-898 | C2H2-type 14; degenerate | ||||
Sequence: MKCPYCDFYFMKNGSDLQRHIWAH | ||||||
Zinc finger | 904-926 | C2H2-type 15 | ||||
Sequence: FKCSLCEYATRSKSNLKAHMNRH | ||||||
Zinc finger | 932-954 | C2H2-type 16 | ||||
Sequence: HLCDMCGKKFKSKGTLKSHKLLH | ||||||
Zinc finger | 961-983 | C2H2-type 17 | ||||
Sequence: FKCTVCDYTAAQKPQLLRHMEQH | ||||||
Zinc finger | 989-1012 | C2H2-type 18 | ||||
Sequence: FRCAHCHYSCNISGSLKRHYNRKH | ||||||
Zinc finger | 1036-1059 | C2H2-type 19 | ||||
Sequence: LKCPVCSFVYGTKWEFNRHLKNKH |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q7TS63-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length1,237
- Mass (Da)137,883
- Last updated2008-07-22 v2
- Checksum085176A902B319E9
Q7TS63-2
- Name2
- Differences from canonical
- 144-150: Missing
- 1063-1073: Missing
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
E0CX30 | E0CX30_MOUSE | Zfat | 1152 |
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_034940 | 144-150 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 153-184 | Basic and acidic residues | ||||
Sequence: SDLDLEKTYKEDDREKASKRPRAQKTEKVQKI | ||||||
Compositional bias | 608-630 | Polar residues | ||||
Sequence: PPAAAEATSDTQHRDSAQTQGEE | ||||||
Alternative sequence | VSP_034941 | 1063-1073 | in isoform 2 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
EU221277 EMBL· GenBank· DDBJ | ABY67968.1 EMBL· GenBank· DDBJ | mRNA | ||
BC053930 EMBL· GenBank· DDBJ | AAH53930.1 EMBL· GenBank· DDBJ | mRNA |