Q7TPV2 · DZIP3_MOUSE
- ProteinE3 ubiquitin-protein ligase DZIP3
- GeneDzip3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1204 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA.
Catalytic activity
Pathway
Protein modification; protein ubiquitination.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | metal ion binding | |
Molecular Function | phosphatase binding | |
Molecular Function | polyubiquitin modification-dependent protein binding | |
Molecular Function | RNA binding | |
Molecular Function | ubiquitin protein ligase activity | |
Molecular Function | ubiquitin-protein transferase activity | |
Biological Process | protein polyubiquitination |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameE3 ubiquitin-protein ligase DZIP3
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ7TPV2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000055899 | 1-1204 | E3 ubiquitin-protein ligase DZIP3 | |||
Sequence: MDSLAEEFFVSGNPDVEEQTKEETEIIAEKPVTQLDKQKMDISADPEPVNALLEIKKVLNPISALPKGVFPNIEKFIQEDFSFQTMQREVTTHSQTGEEIVPALTLHFLITQLEMALRNIQASNYTAQQINVGYYLTLLFLYGVALTERAKKEDCIEAENKFLVMKMVIQESEICENFMCLVYFGRGLLRCAQKRYNGALLEFYKSLQEIGDTDDNWFEVDPTDDEDLPTTFKDSLNNFIKTTESNIMKETICSYLDCERSCEADILKNTNYKGFFQLMCSKSCCIYFHKICWKKFKNLKYPGESDQSFSGQKCLKEGCPGDMVRMLQCDVPGIVKILFEVVRKDEYITIENLGASYKNLMSLELTDTDIRPKFNLKPNTKDEVPIFKLDYNYFYHLLHIIIISGTDMVRQIFDEAMPPTLLKKELLIHKNVLEPYYNHLWTNHPLGGSWHLLYPPNKELPQSKQFDLCLLLALIKHLNVFPAPRKGWDMEPPSSDLSKSADILRLCKYRDILLSEILMNGLTELQFNSIWKKVSDILLRLGMKQDDLDKVKENPIENISLDYHQLSIYLGIPVPEIIQRMLSCYQQGITLQSITGSQRLDVEEFQNDEEDLSPPVMEYNIDVKSNTEIQLAEINKDVASIPSESSTESVKDLQEVKSKTKKKKRTKSNKKDKDSEDEQVSYMVEKDDQLETEQVDVNTLSTYMKTDTSDAQEDSAAEDKFCSLDELHILDMVEQGSSGKESTDFKETEKERLAHQHQLYKLQYECEDYKRQLKTVTFRWQENQMLIKKKEKIIVSLNQQVAFGINKMSKLQRQIHAKDDEIKNLKDQLSLKRSQWEMEKHNLESTVKTYLNKLNAETSRALTAEVYFLQCRRDFGLLHLEQTEKECLNQLARVTHMAASNLESLQLKAAVDSWNAIVADVRNKIAFLRTQYNEQINKVKQGFALSTLPPVQLPPPPPSPEILIQQFLGRPLVKESFFRPILTVPQMPAVCPGVISAAVQPRPPLMPGITWAMPTPIGDTVSPSASLCSEPLMINWERITDRLKTAFPQQTRKELTDFLQQLKDSHGKSVSRLTFDEIVYKISQMIEPKKSESEEKSAQDGNNASPSHTASQPNAPQDPKSAQGSATWEGDKDMDNEEEEEEPCVICHENLSPENLSVLPCAHKFHSQCIRPWLMQQGTCPTCRLHVLQPEEFPGHPNGQLPKI |
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, coiled coil, compositional bias, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-22 | Disordered | ||||
Sequence: MDSLAEEFFVSGNPDVEEQTKE | ||||||
Region | 640-681 | Disordered | ||||
Sequence: SIPSESSTESVKDLQEVKSKTKKKKRTKSNKKDKDSEDEQVS | ||||||
Coiled coil | 746-861 | |||||
Sequence: KETEKERLAHQHQLYKLQYECEDYKRQLKTVTFRWQENQMLIKKKEKIIVSLNQQVAFGINKMSKLQRQIHAKDDEIKNLKDQLSLKRSQWEMEKHNLESTVKTYLNKLNAETSRA | ||||||
Coiled coil | 906-941 | |||||
Sequence: QLKAAVDSWNAIVADVRNKIAFLRTQYNEQINKVKQ | ||||||
Region | 1088-1141 | Disordered | ||||
Sequence: PKKSESEEKSAQDGNNASPSHTASQPNAPQDPKSAQGSATWEGDKDMDNEEEEE | ||||||
Compositional bias | 1098-1124 | Polar residues | ||||
Sequence: AQDGNNASPSHTASQPNAPQDPKSAQG | ||||||
Zinc finger | 1144-1184 | RING-type; atypical | ||||
Sequence: CVICHENLSPENLSVLPCAHKFHSQCIRPWLMQQGTCPTCR |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q7TPV2-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length1,204
- Mass (Da)138,021
- Last updated2004-07-19 v2
- Checksum9522730708DB570C
Q7TPV2-2
- Name2
- Differences from canonical
- 382-587: Missing
Q7TPV2-3
- Name3
- Differences from canonical
- 1-889: Missing
- 890-899: QLARVTHMAA → MFPLCLLFYI
- 1135-1153: DNEEEEEEPCVICHENLSP → VRPNLLTVNTFRSERKRMV
- 1154-1204: Missing
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for alternative sequence, sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_010973 | 1-889 | in isoform 3 | |||
Sequence: Missing | ||||||
Sequence conflict | 306 | in Ref. 2; AAH52893 | ||||
Sequence: D → G | ||||||
Alternative sequence | VSP_010977 | 382-587 | in isoform 2 | |||
Sequence: Missing | ||||||
Sequence conflict | 650 | in Ref. 2; AAH52893 | ||||
Sequence: V → I | ||||||
Alternative sequence | VSP_010974 | 890-899 | in isoform 3 | |||
Sequence: QLARVTHMAA → MFPLCLLFYI | ||||||
Compositional bias | 1098-1124 | Polar residues | ||||
Sequence: AQDGNNASPSHTASQPNAPQDPKSAQG | ||||||
Alternative sequence | VSP_010975 | 1135-1153 | in isoform 3 | |||
Sequence: DNEEEEEEPCVICHENLSP → VRPNLLTVNTFRSERKRMV | ||||||
Alternative sequence | VSP_010976 | 1154-1204 | in isoform 3 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK122344 EMBL· GenBank· DDBJ | BAC65626.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
BC052893 EMBL· GenBank· DDBJ | AAH52893.1 EMBL· GenBank· DDBJ | mRNA | ||
BC117953 EMBL· GenBank· DDBJ | AAI17954.1 EMBL· GenBank· DDBJ | mRNA | ||
BC117954 EMBL· GenBank· DDBJ | AAI17955.1 EMBL· GenBank· DDBJ | mRNA | ||
AK039172 EMBL· GenBank· DDBJ | BAC30265.1 EMBL· GenBank· DDBJ | mRNA | ||
BI736207 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
CN535823 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
BG070132 EMBL· GenBank· DDBJ | - | mRNA | No translation available. |