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Q7TPB0 · PLPR3_MOUSE

  • Protein
    Phospholipid phosphatase-related protein type 3
  • Gene
    Plppr3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

Caution

Has most probably no phospholipid phosphatase activity (By similarity).
This is supported by the fact that the phosphatase sequence motifs as well as the His residue acting as a nucleophile in active phosphatases of the PA-phosphatase related phosphoesterase family are not conserved (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Molecular Functionphosphatidate phosphatase activity
Biological Processphospholipid metabolic process

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phospholipid phosphatase-related protein type 3
  • Alternative names
    • Inactive phospholipid phosphatase PLPPR3
    • Lipid phosphate phosphatase-related protein type 3
    • Plasticity-related gene 2 protein
      (PRG-2
      )

Gene names

    • Name
      Plppr3
    • Synonyms
      Kiaa4076, Lppr3
      , Prg2

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q7TPB0
  • Secondary accessions
    • Q4V781
    • Q68FN2
    • Q6NZQ9

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane18-38Helical
Transmembrane70-90Helical
Transmembrane131-151Helical
Transmembrane205-225Helical
Transmembrane231-251Helical
Transmembrane261-281Helical

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation, modified residue.

Type
IDPosition(s)Description
ChainPRO_00003175301-716Phospholipid phosphatase-related protein type 3
Glycosylation167N-linked (GlcNAc...) asparagine
Glycosylation316N-linked (GlcNAc...) asparagine
Modified residue320Phosphoserine
Modified residue351Phosphoserine
Modified residue374Phosphothreonine
Modified residue426Phosphoserine
Modified residue505Phosphoserine
Modified residue641Phosphoserine

Keywords

Proteomic databases

PTM databases

Interaction

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region311-335Disordered
Region416-515Disordered
Compositional bias437-460Acidic residues
Region548-589Disordered
Compositional bias557-582Polar residues
Region630-651Disordered
Region663-693Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q7TPB0-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    716
  • Mass (Da)
    76,693
  • Last updated
    2003-10-01 v1
  • MD5 Checksum
    4A1D6BFF776A78CACFDCCCEC31A51A29
MLAMKEKNKTPKDSMTLLPCFYFVELPIVASSIVSLYFLELTDLFKPAKVGFQCYDRALSMPYVETNEELIPLLMLLSLAFAAPAASIMVGEGMVYCLQSRLWGRGPGGVEGSINAGGCNFNSFLRRTVRFVGVHVFGLCATALVTDVIQLATGYHTPFFLTVCKPNYTLLGTSCESNPYITQDICSGHDTHAILSARKTFPSQHATLSAFAAVYVSMYFNAVISDTTKLLKPILVFAFAIAAGVCGLTQITQYRSHPVDVYAGFLIGAGIAAYLACHAVGNFQAPPAEKVPTPAPAKDALRALTQRGHESMYQQNKSVSTDELGPPGRLEGVPRPVAREKTSLGSLKRASVDVDLLAPRSPMGKEGMVTFSNTLPRVSTPSLDDPARRHMTIHVPLDASRSRQLIGEWKQKSLEGRGLGLPDEASPVHLRAPAEQVAEEEEEEEEEEEEEEEEEEEEGPVPPSLYPTVQARPGLGPRVILPPRPGPQPLVHIPEEGVQAGAGLSPKSSSSSVRAKWLSVAEKGGGPVAVAPSQPRVANPPRLLQVIAMSKAAGGPKAETASSSSASSDSSQYRSPSDRDSASIVTIDAHAPHHPVVHLSAGSTPWEWKAKVVEGEGSYELGDLARGFRSSCKQPGMGPGSPVSDVDQEEPRFGAVATVNLATGEGLPPPGASEGALGAGSRESTLRRQVGGLAEREVEAEAESYYRRMQARRYQD

Q7TPB0-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 408-463: EWKQKSLEGRGLGLPDEASPVHLRAPAEQVAEEEEEEEEEEEEEEEEEEEEGPVPP → SSPAAHHRRRLGNPGNNRKQKNRAVSWQRNSGSGKKKKWEGRGGKKKVAKHRSVNT
    • 464-716: Missing

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E9QAX3E9QAX3_MOUSEPlppr3454
E9PZA9E9PZA9_MOUSEPlppr3217
E9PVZ4E9PVZ4_MOUSEPlppr3159
E9Q8U7E9Q8U7_MOUSEPlppr3266
E9Q4F1E9Q4F1_MOUSEPlppr363
A0A0R3P9D0A0A0R3P9D0_MOUSEPlppr3716

Features

Showing features for alternative sequence, compositional bias, sequence conflict.

Type
IDPosition(s)Description
Alternative sequenceVSP_031007408-463in isoform 2
Compositional bias437-460Acidic residues
Alternative sequenceVSP_031008464-716in isoform 2
Sequence conflict520in Ref. 2; AAH66006/AAH79534
Compositional bias557-582Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF541278
EMBL· GenBank· DDBJ
AAP57767.1
EMBL· GenBank· DDBJ
mRNA
BC066006
EMBL· GenBank· DDBJ
AAH66006.1
EMBL· GenBank· DDBJ
mRNA
BC079534
EMBL· GenBank· DDBJ
AAH79534.1
EMBL· GenBank· DDBJ
mRNA
BC098099
EMBL· GenBank· DDBJ
AAH98099.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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