Q7TNS2 · MIC10_MOUSE

  • Protein
    MICOS complex subunit Mic10
  • Gene
    Micos10
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentMICOS complex
Cellular Componentmitochondrion
Biological Processcristae formation

Names & Taxonomy

Protein names

  • Recommended name
    MICOS complex subunit Mic10
  • Alternative names
    • Mitochondrial inner membrane organizing system protein 1

Gene names

    • Name
      Micos10
    • Synonyms
      Mic10, Minos1

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • DBA/2J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q7TNS2
  • Secondary accessions
    • A2ALL2
    • Q3U6N5

Proteomes

Organism-specific databases

Subcellular Location

Mitochondrion inner membrane
; Single-pass membrane protein
Note: The C-terminus is located in the intermembrane space, while the location of the N-terminus has not been determined yet. As some programs predict the presence of 2 closely apposed membrane domains, it has been proposed that the protein may cross the membrane twice and that both termini may face the intermembrane space.

Features

Showing features for transmembrane, topological domain.

Type
IDPosition(s)Description
Transmembrane17-36Helical
Topological domain37-76Mitochondrial intermembrane

Keywords

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain.

Type
IDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylserine
ChainPRO_00002216352-76MICOS complex subunit Mic10

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and MICOS13/MIC13 (By similarity).
This complex was also known under the names MINOS or MitOS complex (By similarity).
The MICOS complex associates with mitochondrial outer membrane proteins SAMM50, MTX1 and MTX2 (together described as components of the mitochondrial outer membrane sorting assembly machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane protein TMEM11 and with HSPA9 (By similarity).
The MICOS and SAM complexes together with DNAJC11 are part of a large protein complex spanning both membranes termed the mitochondrial intermembrane space bridging (MIB) complex. Interacts with IMMT/MIC60 and MICOS13/MIC13 (By similarity).
Interacts with APOO/MIC23/MIC26 and APOOL/MIC27 (By similarity).
Interacts with ARMC1 (By similarity).

Protein-protein interaction databases

Miscellaneous

Sequence

  • Sequence status
    Complete
  • Length
    76
  • Mass (Da)
    8,567
  • Last updated
    2003-10-01 v1
  • Checksum
    048EB353CD1506A3
MSESELGRKWDRCMADTVVKLGTGFGLGIVFSLTFFKRRMWPLAFGSGVGLGMAYSNCQHDFQAPYLLHGKYVKEQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK152509
EMBL· GenBank· DDBJ
BAE31274.1
EMBL· GenBank· DDBJ
mRNA
AK153063
EMBL· GenBank· DDBJ
BAE31689.1
EMBL· GenBank· DDBJ
mRNA
AK159100
EMBL· GenBank· DDBJ
BAE34816.1
EMBL· GenBank· DDBJ
mRNA
AK167818
EMBL· GenBank· DDBJ
BAE39842.1
EMBL· GenBank· DDBJ
mRNA
AL805923
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL807811
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC055791
EMBL· GenBank· DDBJ
AAH55791.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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