Q7TNC4 · LC7L2_MOUSE

  • Protein
    Putative RNA-binding protein Luc7-like 2
  • Gene
    Luc7l2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May bind to RNA via its Arg/Ser-rich domain.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnuclear speck
Cellular ComponentU1 snRNP
Cellular ComponentU2-type prespliceosome
Molecular Functionenzyme binding
Molecular FunctionmRNA binding
Biological ProcessmRNA splice site recognition

Names & Taxonomy

Protein names

  • Recommended name
    Putative RNA-binding protein Luc7-like 2
  • Alternative names
    • CGI-74 homolog

Gene names

    • Name
      Luc7l2

Organism names

  • Taxonomic identifier
  • Strains
    • NMRI
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q7TNC4
  • Secondary accessions
    • Q99LM5
    • Q99PC3

Proteomes

Organism-specific databases

Subcellular Location

Nucleus speckle
Nucleus, nucleoplasm
Note: Colocalizes with SCNM1 and SNRNP70 in nuclear speckles.

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001872831-392Putative RNA-binding protein Luc7-like 2
Modified residue18Phosphoserine
Modified residue2665-hydroxylysine; by JMJD6
Modified residue2695-hydroxylysine; by JMJD6

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

All isoforms are expressed in brain, kidney, heart, thymus, stomach, skeletal muscle, testis and spinal cord.

Gene expression databases

Interaction

Subunit

Interacts with SCNM1.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for coiled coil, compositional bias, region.

TypeIDPosition(s)Description
Coiled coil102-177
Compositional bias235-261Basic and acidic residues
Region235-392Disordered
Compositional bias262-328Basic residues
Compositional bias329-392Basic and acidic residues

Sequence similarities

Belongs to the Luc7 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing.

Q7TNC4-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    392
  • Mass (Da)
    46,583
  • Last updated
    2003-10-01 v1
  • Checksum
    1A5202B1F537A7CC
MSAQAQMRAMLDQLMGTSRDGDTTRQRIKFSDDRVCKSHLLNCCPHDVLSGTRMDLGECLKVHDLALRADYEIASKEQDFFFELDAMDHLQSFIADCDRRTEVSKKRLAETQEEISAEVAAKAERVHELNEEIGKLLAKVEQLGAEGNVEESQKVMDEVEKARAKKREAEEVYRNSMPASSFQQQKLRVCEVCSAYLGLHDNDRRLADHFGGKLHLGFIEIREKLEELKRVVAEKQEKRNQERLKRREEREREEREKLRRSRSHSKNPKRSRSREHRRHRSRSMSRERKRRTRSKSREKRHRHRSRSSSRSRSRSHQRSRHSSRDRSRERSKRRSSKERFRDQDLASRDRDRSSRDRSPRDRDRKDKKRSYESANGRSEDRRSSEEREAGEI

Q7TNC4-2

Q7TNC4-3

Q7TNC4-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E9Q715E9Q715_MOUSELuc7l2272
Q05CX5Q05CX5_MOUSELuc7l2339
E0CYQ8E0CYQ8_MOUSELuc7l280
E0CZB9E0CZB9_MOUSELuc7l299

Features

Showing features for sequence conflict, compositional bias, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict147in Ref. 2; AAH56383
Compositional bias235-261Basic and acidic residues
Sequence conflict245in Ref. 1; AAK01182
Sequence conflict259in Ref. 1; AAK01182
Alternative sequenceVSP_010218260-269in isoform 2 and isoform 4
Compositional bias262-328Basic residues
Compositional bias329-392Basic and acidic residues
Alternative sequenceVSP_010219335in isoform 2 and isoform 3
Alternative sequenceVSP_010220336-392in isoform 2 and isoform 3

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF318301
EMBL· GenBank· DDBJ
AAK01182.1
EMBL· GenBank· DDBJ
mRNA
BC002314
EMBL· GenBank· DDBJ
AAH02314.1
EMBL· GenBank· DDBJ
mRNA
BC056354
EMBL· GenBank· DDBJ
AAH56354.1
EMBL· GenBank· DDBJ
mRNA
BC056383
EMBL· GenBank· DDBJ
AAH56383.1
EMBL· GenBank· DDBJ
mRNA
BC056970
EMBL· GenBank· DDBJ
AAH56970.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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