Q7TN16 · HHIP_MOUSE

  • Protein
    Hedgehog-interacting protein
  • Gene
    Hhip
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Modulates hedgehog signaling in several cell types, including brain and lung through direct interaction with members of the hedgehog family. Soluble forms inhibit Shh-induced differentiation in the fibroblast cell line C3H/10T1/2.

Features

Showing features for binding site.

170050100150200250300350400450500550600650700
TypeIDPosition(s)Description
Binding site383Zn2+ (UniProtKB | ChEBI); ligand shared with SHH

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell surface
Cellular Componentextracellular region
Cellular Componentplasma membrane
Molecular Functionhedgehog family protein binding
Molecular Functionzinc ion binding
Biological Processanimal organ morphogenesis
Biological Processdorsal/ventral pattern formation
Biological Processepithelial tube branching involved in lung morphogenesis
Biological Processnegative regulation of angiogenesis
Biological Processnegative regulation of apoptotic process
Biological Processnegative regulation of signal transduction
Biological Processnegative regulation of smoothened signaling pathway
Biological Processneuroblast proliferation
Biological Processregulation of fibroblast growth factor receptor signaling pathway
Biological Processsignal transduction
Biological Processskeletal system morphogenesis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hedgehog-interacting protein
  • Short names
    HHIP; HIP

Gene names

    • Name
      Hhip
    • Synonyms
      Hip

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q7TN16
  • Secondary accessions
    • Q8C0B0
    • Q9WU59

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Peripheral membrane protein
Secreted
Note: The last 22 C-terminal amino acids may participate in cell membrane attachment.

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-17
ChainPRO_000000762418-700Hedgehog-interacting protein
Glycosylation99N-linked (GlcNAc...) asparagine
Disulfide bond216↔536
Disulfide bond218↔543
Disulfide bond402↔624
Glycosylation416N-linked (GlcNAc...) asparagine
Disulfide bond435↔452
Glycosylation447N-linked (GlcNAc...) asparagine
Glycosylation459N-linked (GlcNAc...) asparagine
Disulfide bond500↔594
Disulfide bond612↔623
Disulfide bond625↔634
Disulfide bond639↔649
Disulfide bond643↔655
Disulfide bond657↔666

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

In the adult brain, high expression found in the ventral cochlear nucleus, medial habenula, indusium griseum and tenia tecta. Some expression also in the caudate putamen, the nucleus accumbens, the ventral pallidum and in the superficial layers of the superior colliculus.

Developmental stage

First detected at 8.75 dpc, in the ventral midline of the neural tube and in the ventral medial somites. At 10.5 dpc, expression in the notochord is maintained in the caudal region. Expression is lost in the floor plate, but is retained in the ventral half of the neural tube and in the sclerotome of the adjacent somites. In the midbrain, expression confined to two lateral stripes adjacent to the floor plate. Also expressed in the gut mesenchyme along the length of the gastro-intestinal tract and in the mesenchyme of the posterior half of the limb. Expressed in the underlying mesenchyme of the epithelium of a number of tissues including lung, gut and whisker. Also expressed in the perichondrium and in the androgen-producing interstitial somatic cells of the developing testis.

Gene expression databases

Interaction

Subunit

Interacts with all three hedgehog family members, SHH, IHH and DHH.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region376-388Interaction with SHH zinc binding site
Domain607-634EGF-like 1
Domain635-667EGF-like 2

Domain

A flexible loop interacts with the SHH zinc binding site and contributes to zinc binding.

Sequence similarities

Belongs to the HHIP family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    700
  • Mass (Da)
    78,513
  • Last updated
    2005-03-29 v2
  • Checksum
    91007C5AF6070B80
MLKMLSFKLLLLAVALGFFEGDAKFGERNEGSGARRRRCLNGNPPKRLKRRDRRVMSQLELLSGGEILCGGFYPRVSCCLQSDSPGLGRLENKIFSATNNSECSRLLEEIQCAPCSPHSQSLFYTPERDVLDGDLALPLLCKDYCKEFFYTCRGHIPGLLQTTADEFCFYYARKDAGLCFPDFPRKQVRGPASNYLGQMEDYEKVGGISRKHKHNCLCVQEVMSGLRQPVSAVHSGDGSHRLFILEKEGYVKILTPEGELFKEPYLDIHKLVQSGIKGGDERGLLSLAFHPNYKKNGKLYVSYTTNQERWAIGPHDHILRVVEYTVSRKNPHQVDVRTARVFLEVAELHRKHLGGQLLFGPDGFLYIILGDGMITLDDMEEMDGLSDFTGSVLRLDVDTDMCNVPYSIPRSNPHFNSTNQPPEVFAHGLHDPGRCAVDRHPTDININLTILCSDSNGKNRSSARILQIIKGRDYESEPSLLEFKPFSNGPLVGGFVYRGCQSERLYGSYVFGDRNGNFLTLQQSPVTKQWQEKPLCLGASSSCRGYFSGHILGFGEDELGEVYILSSSKSMTQTHNGKLYKIVDPKRPLMPEECRVTVQPAQPLTSDCSRLCRNGYYTPTGKCCCSPGWEGDFCRIAKCEPACRHGGVCVRPNKCLCKKGYLGPQCEQVDRNVRRVTRAGILDQIIDMTSYLLDLTSYIV

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict29in Ref. 1; AAD31172
Sequence conflict473in Ref. 3; AAH53012
Sequence conflict607in Ref. 2; BAC27575

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF116865
EMBL· GenBank· DDBJ
AAD31172.1
EMBL· GenBank· DDBJ
mRNA
AK031841
EMBL· GenBank· DDBJ
BAC27575.1
EMBL· GenBank· DDBJ
mRNA
BC053012
EMBL· GenBank· DDBJ
AAH53012.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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