Q7T7H5 · Q7T7H5_9HEPC
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids3033 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
Cofactor
Protein has several cofactor binding sites:
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Organism names
- Organism
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Hepacivirus > Hepacivirus hominis
Accessions
- Primary accessionQ7T7H5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Endoplasmic reticulum membrane ; Single-pass membrane protein
Endoplasmic reticulum membrane ; Single-pass type I membrane protein
Host endoplasmic reticulum membrane ; Multi-pass membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Single-pass membrane protein
Host endoplasmic reticulum membrane ; Single-pass type I membrane protein
Host mitochondrion membrane ; Single-pass type I membrane protein
Membrane ; Multi-pass membrane protein
Membrane ; Peripheral membrane protein
Membrane ; Single-pass membrane protein
Membrane ; Single-pass type I membrane protein
Mitochondrion membrane ; Single-pass type I membrane protein
Virion membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 722-744 | Helical | ||||
Sequence: WVVLLFLLLADARVCACLWMLII | ||||||
Transmembrane | 756-782 | Helical | ||||
Sequence: IILHSASAASANGLLWFFIFFTAAWYL | ||||||
Transmembrane | 789-808 | Helical | ||||
Sequence: VATYSVLGLWSFLLLVLALP | ||||||
Transmembrane | 820-839 | Helical | ||||
Sequence: GELGLVMIAIISIFTLTPAY | ||||||
Transmembrane | 846-865 | Helical | ||||
Sequence: SVWWLSYMLVLAEALIQQWA | ||||||
Transmembrane | 1663-1687 | Helical | ||||
Sequence: TWVLAGGVLAAVAAYCLATGCVSII | ||||||
Transmembrane | 1828-1849 | Helical | ||||
Sequence: AGATGFVVSGLVGAAVGSIGLG | ||||||
Transmembrane | 1855-1874 | Helical | ||||
Sequence: VLAGYGAGISGALVAFKIMS | ||||||
Transmembrane | 1886-1906 | Helical | ||||
Sequence: LLPAILSPGALVVGVICAAIL | ||||||
Transmembrane | 3013-3032 | Helical | ||||
Sequence: LLLLCLLLLSVGVGIFLLPA |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-79 | Disordered | ||||
Sequence: MSTNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRGRRQPIPKDRRSTGKSWGKP | ||||||
Compositional bias | 47-74 | Basic and acidic residues | ||||
Sequence: RATRKTSERSQPRGRRQPIPKDRRSTGK | ||||||
Domain | 903-1030 | Peptidase C18 | ||||
Sequence: AYLLRESLLRVPYFVRAHALLRVCTLVRHLAGAKYIQMLLITIGRWTGTYIYDHLSPLSTWAAQGLRDLAVAVEPVVFSPMEKKVIVWGAETVACGDILHGLPVSARLGREVLLGPADGYTSKGWKLL | ||||||
Domain | 1031-1212 | Peptidase S29 | ||||
Sequence: APITAYTQQTRGLLGAIVVSLTGRDKNEQAGQVQVLSSVTQSFLGTSISGVLWTVYHGAGNKTLAGPKGPVTQMYTSAEGDLVGWPSPPGTKSLDPCTCGAVDLYLVTRNADVIPVRRKDDRRGALLSPRPLSTLKGSSGGPVLCSRGHAVGLFRAAVCTRGVAKSIDFIPVESLDIAARSP | ||||||
Domain | 1221-1373 | Helicase ATP-binding | ||||
Sequence: PAVPQSYQVGYLHAPTGSGKSTKVPAAYASQGYKVLVLNPSVAATLGFGAYMSKAHGINPNIRTGVRTVTTGDPITYSTYGKFLADEGCSAGAYDVIICDECHAVDSTTILGIGTVLDQAETAGARLVVLATATPPGTVTTPHSNIEEVALGH | ||||||
Domain | 1365-1542 | Helicase C-terminal | ||||
Sequence: NIEEVALGHEGEIPFYGKAIPLAFIKGGRHLIFCHSKKKCDELAAALRGMGVNAVAYYRGLDVSVIPTQGDVVVVATDALMTGYTGDFDSVIDCNVAVTQIVDFSLDPTFTITTQTVPQDAVSRSQRRGRTGRGRLGIYRYVSSGERPSGMFDSVVLCECYDAGAAWYELTPAETTVR | ||||||
Region | 2194-2213 | Disordered | ||||
Sequence: LARGSPPSQASSSASQLSAP | ||||||
Compositional bias | 2198-2213 | Polar residues | ||||
Sequence: SPPSQASSSASQLSAP | ||||||
Region | 2314-2338 | Disordered | ||||
Sequence: CAFPPTSQTPVPPPRRRRAKVLTQD | ||||||
Region | 2355-2431 | Disordered | ||||
Sequence: LQDLNDSGHSTGADTGGDSVQQPSDETADSEAGSLSSMPPLEGEPGDPDLEFEPAGSTPPSEGECEAIDSDSKSWST | ||||||
Compositional bias | 2357-2388 | Polar residues | ||||
Sequence: DLNDSGHSTGADTGGDSVQQPSDETADSEAGS | ||||||
Domain | 2656-2774 | RdRp catalytic | ||||
Sequence: PMGFSYDTRCFDSTVTERDIRTEESIYQACSLPQEARTVIHSLTERLYVGGPMTNSKGQSCGYRRCRASGVFTTSMGNTMTCYIKALAACKAAGIVDPIMLVCGDDLVVISESQGNEED |
Sequence similarities
Belongs to the hepacivirus polyprotein family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length3,033
- Mass (Da)330,531
- Last updated2003-10-01 v1
- Checksum6350976D6C0500E5
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 47-74 | Basic and acidic residues | ||||
Sequence: RATRKTSERSQPRGRRQPIPKDRRSTGK | ||||||
Compositional bias | 2198-2213 | Polar residues | ||||
Sequence: SPPSQASSSASQLSAP | ||||||
Compositional bias | 2357-2388 | Polar residues | ||||
Sequence: DLNDSGHSTGADTGGDSVQQPSDETADSEAGS |