Q7T3Q3 · Q7T3Q3_DANRE
- ProteinCannabinoid receptor
- Genecnr1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids475 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
G-protein coupled receptor for cannabinoids. Mediates many cannabinoid-induced effects in the central nervous system (CNS), as well as in peripheral tissues. Signaling typically involves reduction in cyclic AMP.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | cytoplasm | |
Cellular Component | mitochondrial outer membrane | |
Cellular Component | plasma membrane | |
Cellular Component | presynapse | |
Molecular Function | cannabinoid receptor activity | |
Molecular Function | G protein-coupled receptor activity | |
Biological Process | adenylate cyclase-activating G protein-coupled receptor signaling pathway | |
Biological Process | axonal fasciculation | |
Biological Process | axonogenesis | |
Biological Process | lipid biosynthetic process | |
Biological Process | liver development | |
Biological Process | methionine metabolic process | |
Biological Process | positive regulation of feeding behavior | |
Biological Process | regulation of metabolic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCannabinoid receptor
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ7T3Q3
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 125-149 | Helical | ||||
Sequence: LAIAVLSLTLGTFTVLENLVVLCVI | ||||||
Transmembrane | 161-183 | Helical | ||||
Sequence: YHFIGSLAIADLLGSVIFVYSFL | ||||||
Transmembrane | 195-220 | Helical | ||||
Sequence: NVFLFKLGGVTASFTASVGSLFLTAI | ||||||
Transmembrane | 241-263 | Helical | ||||
Sequence: AVIAFCMMWAISIIIAVLPLLGW | ||||||
Transmembrane | 283-307 | Helical | ||||
Sequence: YLMFWIGVTSVLVLFIIYAYMYILW | ||||||
Transmembrane | 353-373 | Helical | ||||
Sequence: LVLILVVLVICWGPLLAIMVY | ||||||
Transmembrane | 385-407 | Helical | ||||
Sequence: TVFAFCSMLTLLNSTVNPIIYAL |
Keywords
- Cellular component
PTM/Processing
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 141-405 | G-protein coupled receptors family 1 profile | ||||
Sequence: ENLVVLCVILQSRTLRCRPSYHFIGSLAIADLLGSVIFVYSFLDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYVSIHRPLSYRRIVTRTKAVIAFCMMWAISIIIAVLPLLGWNCKRLNSVCSDIFPLIDENYLMFWIGVTSVLVLFIIYAYMYILWKAHHHAVRMLRRTSQKSLVVHSADGTKVQTPRPDQARMDIRLAKTLVLILVVLVICWGPLLAIMVYDLFWRMGDNIKTVFAFCSMLTLLNSTVNPIIY |
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Length475
- Mass (Da)53,044
- Last updated2003-10-01 v1
- Checksum98FEF62D883605D4
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX537259 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AY148349 EMBL· GenBank· DDBJ | AAN46748.1 EMBL· GenBank· DDBJ | mRNA |