Q7T2I5 · 3S1EC_LATSE
- ProteinErabutoxin c
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission. Binds to Torpedo marmorata nAChR (Kd=0.14 nM) (PubMed:7721859).
Features
Showing features for site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Site | 27 | Moderately important residue for binding to acetylcholine receptor | ||||
Sequence: H | ||||||
Site | 28 | Very important residue for binding to acetylcholine receptor | ||||
Sequence: Q | ||||||
Site | 29 | Key residue for binding to acetylcholine receptor | ||||
Sequence: S | ||||||
Site | 30 | Moderately important residue for binding to acetylcholine receptor | ||||
Sequence: S | ||||||
Site | 31 | Key residue for binding to acetylcholine receptor | ||||
Sequence: Q | ||||||
Site | 46 | Moderately important residue for binding to acetylcholine receptor | ||||
Sequence: Y | ||||||
Site | 48 | Key residue for binding to acetylcholine receptor | ||||
Sequence: K | ||||||
Site | 50 | Very important residue for binding to acetylcholine receptor | ||||
Sequence: W | ||||||
Site | 52 | Very important residue for binding to acetylcholine receptor | ||||
Sequence: D | ||||||
Site | 53 | Moderately important residue for binding to acetylcholine receptor | ||||
Sequence: F | ||||||
Site | 54 | Key residue for binding to acetylcholine receptor | ||||
Sequence: R | ||||||
Site | 55 | Moderately important residue for binding to acetylcholine receptor | ||||
Sequence: G | ||||||
Site | 57 | Very important residue for binding to acetylcholine receptor | ||||
Sequence: I | ||||||
Site | 59 | Very important residue for binding to acetylcholine receptor | ||||
Sequence: E | ||||||
Site | 68 | Very important residue for binding to acetylcholine receptor | ||||
Sequence: K |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | acetylcholine receptor inhibitor activity | |
Molecular Function | ion channel regulator activity | |
Molecular Function | toxin activity |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameErabutoxin c
- Short namesETXC; Ec
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Lepidosauria > Squamata > Bifurcata > Unidentata > Episquamata > Toxicofera > Serpentes > Colubroidea > Elapidae > Laticaudinae > Laticauda
Accessions
- Primary accessionQ7T2I5
- Secondary accessions
Subcellular Location
Phenotypes & Variants
Toxic dose
LD50 is 0.15 mg/kg by intramuscular injection into mice.
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-21 | |||||
Sequence: MKTLLLTLVVVTIVCLDLGYT | ||||||
Chain | PRO_0000035448 | 22-83 | Erabutoxin c | |||
Sequence: RICFNHQSSQPQTTKTCSPGESSCYHKQWSDFRGTIIERGCGCPTVKPGINLSCCESEVCNN | ||||||
Disulfide bond | 24↔45 | |||||
Sequence: CFNHQSSQPQTTKTCSPGESSC | ||||||
Disulfide bond | 38↔62 | |||||
Sequence: CSPGESSCYHKQWSDFRGTIIERGC | ||||||
Disulfide bond | 64↔75 | |||||
Sequence: CPTVKPGINLSC | ||||||
Disulfide bond | 76↔81 | |||||
Sequence: CESEVC |
Keywords
- PTM
Expression
Tissue specificity
Expressed by the venom gland.
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 24-38 | Loop I | ||||
Sequence: CFNHQSSQPQTTKTC | ||||||
Region | 39-44 | Stretch between loop I and loop II | ||||
Sequence: SPGESS | ||||||
Region | 45-62 | Loop II | ||||
Sequence: CYHKQWSDFRGTIIERGC | ||||||
Region | 64-75 | Loop III | ||||
Sequence: CPTVKPGINLSC |
Sequence similarities
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type I alpha-neurotoxin sub-subfamily.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length83
- Mass (Da)9,146
- Last updated2003-10-01 v1
- ChecksumBBB499DE67BE50E4
Keywords
- Technical term