Q7T0B0 · STK40_XENTR
- ProteinSerine/threonine-protein kinase 40
- Genestk40
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids443 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein kinase 40
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Silurana
Accessions
- Primary accessionQ7T0B0
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000252266 | 1-443 | Serine/threonine-protein kinase 40 | |||
Sequence: MKRRASERDAGETSARSKALCSSISGSNAKRAGPFILGPRLGNSPVPSIVQCLARKDGTDDFYQLKILSLEERGDKAGETQEERQGKMLLHTEYSLLSLLHNQDGVVHHHGLFQDRTCEIVEDLEANKLVRKMRKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLGERETVVIFYDVVRVVEALHKKNIVHRDLKLGNMVLNKRTHRITVTNFCLGKHLVSEDDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYSIPEDGRVSESTVCLIRKLLVLDPQQRLTASEVLESLGAIISSWQSMSSLSGPLQVVPDIDHLTSLENSQEAKVTEESSQYEFENYMRQQLLLAEEKNTIHEAKNFPQKRHFGNFPPIRRLGYDAQPVSPLDAAILAQRYLPPPHMALSNSH |
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-26 | Disordered | ||||
Sequence: MKRRASERDAGETSARSKALCSSISG | ||||||
Domain | 35-332 | Protein kinase | ||||
Sequence: FILGPRLGNSPVPSIVQCLARKDGTDDFYQLKILSLEERGDKAGETQEERQGKMLLHTEYSLLSLLHNQDGVVHHHGLFQDRTCEIVEDLEANKLVRKMRKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLGERETVVIFYDVVRVVEALHKKNIVHRDLKLGNMVLNKRTHRITVTNFCLGKHLVSEDDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYSIPEDGRVSESTVCLIRKLLVLDPQQRLTASEVLESLGAII |
Sequence similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length443
- Mass (Da)50,140
- Last updated2019-02-13 v2
- Checksum606C8D1B179D133E
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 16 | in Ref. 1; AAQ01592 | ||||
Sequence: R → K | ||||||
Sequence conflict | 71 | in Ref. 1; AAQ01592 | ||||
Sequence: E → D | ||||||
Sequence conflict | 73 | in Ref. 1; AAQ01592 | ||||
Sequence: R → K |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY336058 EMBL· GenBank· DDBJ | AAQ01592.1 EMBL· GenBank· DDBJ | mRNA | ||
AAMC01091013 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AAMC01091014 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC161237 EMBL· GenBank· DDBJ | AAI61237.1 EMBL· GenBank· DDBJ | mRNA |