Q7SZM5 · Q7SZM5_DANRE

Function

Catalytic activity

  • Cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln.
    EC:3.4.24.24 (UniProtKB | ENZYME | Rhea)

Cofactor

Protein has several cofactor binding sites:
Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Can bind about 5 Ca2+ ions per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Features

Showing features for binding site, active site.

165750100150200250300350400450500550600650
TypeIDPosition(s)Description
Binding site102Zn2+ 2 (UniProtKB | ChEBI); catalytic; in inhibited form
Binding site134Ca2+ 1 (UniProtKB | ChEBI)
Binding site168Ca2+ 2 (UniProtKB | ChEBI)
Binding site178Zn2+ 1 (UniProtKB | ChEBI)
Binding site180Zn2+ 1 (UniProtKB | ChEBI)
Binding site185Ca2+ 3 (UniProtKB | ChEBI)
Binding site186Ca2+ 3 (UniProtKB | ChEBI)
Binding site190Ca2+ 3 (UniProtKB | ChEBI)
Binding site193Zn2+ 1 (UniProtKB | ChEBI)
Binding site202Ca2+ 2 (UniProtKB | ChEBI)
Binding site204Ca2+ 2 (UniProtKB | ChEBI)
Binding site206Zn2+ 1 (UniProtKB | ChEBI)
Binding site208Ca2+ 3 (UniProtKB | ChEBI)
Binding site209Ca2+ 1 (UniProtKB | ChEBI)
Binding site211Ca2+ 3 (UniProtKB | ChEBI)
Binding site211Ca2+ 1 (UniProtKB | ChEBI)
Active site231
Active site404
Binding site473Ca2+ 4 (UniProtKB | ChEBI)
Binding site518Ca2+ 4 (UniProtKB | ChEBI)
Binding site520Ca2+ 5 (UniProtKB | ChEBI)
Binding site568Ca2+ 5 (UniProtKB | ChEBI)
Binding site615Ca2+ 4 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular matrix
Cellular Componentextracellular space
Cellular Componentsarcomere
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processcollagen catabolic process
Biological Processextracellular matrix organization
Biological Processhematopoietic stem cell migration
Biological Processlymph vessel development
Biological Processpositive regulation of transforming growth factor beta receptor signaling pathway
Biological Processproteolysis
Biological Processresponse to hypoxia
Biological Processretinal ganglion cell axon guidance
Biological Processtissue remodeling

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    72 kDa type IV collagenase
  • EC number
  • Alternative names
    • 72 kDa gelatinase
    • Matrix metalloproteinase-2

Gene names

    • Name
      mmp2
    • Synonyms
      wu:fa99h12
      , wu:fk89d01

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q7SZM5

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, modified residue.

TypeIDPosition(s)Description
Signal1-29
ChainPRO_503503583030-65772 kDa type IV collagenase
Disulfide bond233↔259
Disulfide bond247↔274
Disulfide bond291↔317
Disulfide bond305↔332
Disulfide bond349↔375
Disulfide bond363↔390
Disulfide bond466↔657
Modified residue549Phosphotyrosine; by PKDCC

Keywords

Family & Domains

Features

Showing features for motif, domain, repeat.

TypeIDPosition(s)Description
Motif100-107Cysteine switch
Domain228-276Fibronectin type-II
Domain286-334Fibronectin type-II
Domain344-392Fibronectin type-II
Repeat469-513Hemopexin
Repeat514-560Hemopexin
Repeat562-610Hemopexin
Repeat611-657Hemopexin

Sequence similarities

Belongs to the peptidase M10A family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    657
  • Mass (Da)
    74,276
  • Last updated
    2003-10-01 v1
  • Checksum
    09E4CC660B46B9EA
MLSVKFFRCRHIVLKVFLVQFLASLQTFAAPSPIIKFPGDDTAHTDKEVALHYLNKFYGCPKDRCNLMVLKDTLKKMQKFFALPETGEIDQKTVEIMKKPRCGVPDVANYNFFHRKPKWGQKNVTYRILGHTPDLDEDTIDDAFYRAFKVWSDVTPLKFTRIMDGEADIMINFGRNEHGDGYPFDGKDGLLAHAFAPGPGIGGDSHFDDDEQWTLGEGQVVKVKYGNAEGEFCKFPFLFMGKEYNSCTSQGRDDGFLWCSTTYNFDDDGKYGFCPHELLFTLGGNADGAPCKFPFTFQGDKYDSCTTSGRDDGYRWCATTEDYDKDKTYGFCPETAMSTSGGNSDGAPCVFPFKFLGDSYDSCTTSGRNDGKMWCAVTKSFDDDRKWGFCPDQGYSLFLVAAHEFGHALGLEHSDDPGALMAPIYTFTKTLRLSDDDVKGIQELYGEPTDKPLATHTPPVTPMDVCNENIIFDAVAQIRGEIFFFKDRFLFRTADVRKKPTGPMLVATFWSELPEKIDAAYENPLEERTVFFAGDEMWVYSASTLEREYPKKISSMGLPSDLHGIDAAYSFHKTKKTYIFAGNKFWRYNEAKKKMDPGFPKIIADSWTAVPDDLDGALSLNGDGHSYFFKDSHYLKMDDSTLKIIKVGEVKKDWLRC

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY324195
EMBL· GenBank· DDBJ
AAP74482.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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