Q7SZ10 · PP1GB_XENLA

  • Protein
    Serine/threonine-protein phosphatase PP1-gamma catalytic subunit B
  • Gene
    ppp1cc-b
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis (By similarity).
Promotes nuclear envelope reassembly by targeting nuclear membrane vesicles to chromatin at the end of mitosis. Acts by dephosphorylating membrane proteins such as lamin B receptor (lbr) to regulate the binding of membrane proteins to chromatin (By similarity).

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 manganese ions per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site64Mn2+ 1 (UniProtKB | ChEBI)
Binding site66Mn2+ 1 (UniProtKB | ChEBI)
Binding site92Mn2+ 1 (UniProtKB | ChEBI)
Binding site92Mn2+ 2 (UniProtKB | ChEBI)
Binding site124Mn2+ 2 (UniProtKB | ChEBI)
Active site125Proton donor
Binding site173Mn2+ 2 (UniProtKB | ChEBI)
Binding site248Mn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcleavage furrow
Cellular Componentkinetochore
Cellular Componentmidbody
Cellular Componentmitochondrion
Cellular Componentnuclear speck
Cellular Componentnucleolus
Molecular Functionmetal ion binding
Molecular Functionmyosin phosphatase activity
Molecular Functionprotein serine/threonine phosphatase activity
Biological Processcell division
Biological Processglycogen metabolic process
Biological Processmitotic nuclear membrane reassembly
Biological Processprotein dephosphorylation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Serine/threonine-protein phosphatase PP1-gamma catalytic subunit B
  • Short names
    PP-1G-B
  • Alternative names
    • Protein phosphatase 1 zeta
      (xPP1-zeta
      ) (EC:3.1.3.16) . EC:3.1.3.16 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      ppp1cc-b

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus

Accessions

  • Primary accession
    Q7SZ10
  • Secondary accessions
    • A4PB28

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003656351-323Serine/threonine-protein phosphatase PP1-gamma catalytic subunit B

Expression

Gene expression databases

    • 380598Expressed in egg cell and 19 other cell types or tissues

Interaction

Subunit

PP1 comprises a catalytic subunit, ppp1c1, ppp1cb or ppp1cc, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then is complexed to one or several targeting or regulatory subunits.

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region301-323Disordered

Sequence similarities

Belongs to the PPP phosphatase family. PP-1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    323
  • Mass (Da)
    36,938
  • Last updated
    2003-10-01 v1
  • Checksum
    38D4C5DE036A8C2D
MADVDKLNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAEKKKPNASRPVTPPRGIITKQAKK

Sequence caution

The sequence BAF51555.1 differs from that shown. Reason: Erroneous termination Truncated C-terminus.
The sequence BAF51555.1 differs from that shown. Reason: Frameshift

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB106882
EMBL· GenBank· DDBJ
BAF51555.1
EMBL· GenBank· DDBJ
mRNA Sequence problems.
BC054188
EMBL· GenBank· DDBJ
AAH54188.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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