Q7SY09 · AGRL4_DANRE

Function

function

Orphan receptor that plays a role in vessel formation.

Features

Showing features for site.

1727100200300400500600700
TypeIDPosition(s)Description
Site443-444Cleavage; by autolysis

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functioncalcium ion binding
Molecular FunctionG protein-coupled receptor activity
Biological Processadenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Processanimal organ development
Biological Processcell surface receptor signaling pathway

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Adhesion G protein-coupled receptor L4

Gene names

    • Name
      adgrl4
    • Synonyms
      eltd1
      , zgc:63629

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q7SY09
  • Secondary accessions
    • F1QUS5

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain20-467Extracellular
Transmembrane468-488Helical; Name=1
Topological domain489-496Cytoplasmic
Transmembrane497-517Helical; Name=2
Topological domain518-535Extracellular
Transmembrane536-556Helical; Name=3
Topological domain557-568Cytoplasmic
Transmembrane569-589Helical; Name=4
Topological domain590-609Extracellular
Transmembrane610-630Helical; Name=5
Topological domain631-654Cytoplasmic
Transmembrane655-675Helical; Name=6
Topological domain676-682Extracellular
Transmembrane683-703Helical; Name=7

Keywords

Phenotypes & Variants

Disruption phenotype

Morpholino knockdown of the protein causes dramatic vascular impairment in embryos.

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-19
ChainPRO_000043379420-726Adhesion G protein-coupled receptor L4
Disulfide bond56↔69
Disulfide bond63↔78
Disulfide bond106↔118
Disulfide bond112↔127
Disulfide bond408↔438
Disulfide bond426↔440

Post-translational modification

Autoproteolytically processed at the GPS region of the GAIN-B domain; this cleavage modulates receptor activity.

Keywords

Proteomic databases

Expression

Developmental stage

During gastrulation, expression is ubiquitously detected throughout the embryo. During development is detected in epithelial cells, blood precursor cells and developing vessels. By 48 hpf, weaker expression is still detected in epithelials cells.

Interaction

Subunit

Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain52-90EGF-like 1; calcium-binding
Domain102-139EGF-like 2; calcium-binding
Domain282-456GAIN-B
Region408-456GPS

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    727
  • Mass (Da)
    81,948
  • Last updated
    2015-09-16 v2
  • Checksum
    8054707A793E39A9
MKLLLFAAWFSSLLDPCRFLDICQSCHPNADCDDICKCRTGYTGNGISDCRDDNECETVPEICGLHANCTNYVGGYYCNCLSGFISNGTEQFQTNDGTSCNDINECEEDRKCGPNSKCHNNIGSFICSCLRGYTSPAGPWFMPNHGTDCIENSKIHCHQDHKCTKETVNSTLERMTNLSISERLKEIRYQTSAALSPVLLISYIEAMVSSKLNSGDVSKDSKEHVNETITNLVFSVNNLVEKDEKVEWKKINEDLRMYYVTKLLHTAEKETLALSAGYTHATQMQVHAGDVEMKLYTFEPRQAQKHPLSANIQGNSISLSTKKARHANNNGSTSVVFLIYHSIGDLLKPADDPGVADYSRYAAAGEITVNSPVIAAAISNQKTLPLNDVTFTLKHTQEIDPARDETKCAFWEYSPSMMGHWSLDGCIRTRVNTTHTSCSCNHLTHFAILMSSARANLLAHYNVLTRITQLGMVISLICLSMCIFTFWFFRDIQNTRTTIHKNLCCSLFMAQFIFLIGINKSAHKWFCSLIAGLLHYFFLAAFAWMCIEGIHLYLIVVGVIYNKGFLHRNFYAFGYGSPAVVVAISATLGYKYYGTSSVCWLSTENNFIWSFIGPAILIILVNLLAFAVIIYKVYRHTAVKKPEISHYENIRSCARGAIALLFVLGVTWAFGVMYILYETTLTAYLFTFANVFQGMFIFIFLCVLSRRIQEEYYRLFKNMPCCFECLR

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A140TAT8A0A140TAT8_DANREadgrl4735

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict153in Ref. 2; AAH55171
Sequence conflict214in Ref. 2; AAH55171
Sequence conflict257in Ref. 2; AAH55171
Sequence conflict410in Ref. 2; AAH55171
Sequence conflict615in Ref. 2; AAH55171

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CU464206
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC055171
EMBL· GenBank· DDBJ
AAH55171.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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