Q7SXP9 · Q7SXP9_DANRE

Function

function

Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.

Catalytic activity

  • 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H+ = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H+ = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
    This reaction proceeds in the forward direction.
  • 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H+ = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
    This reaction proceeds in the forward direction.
  • 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H+ = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H+ = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H+ = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H+ = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
    This reaction proceeds in the forward direction.
  • 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H+ = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
    This reaction proceeds in the forward direction.
  • a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H+ = a CDP-1,2-diacyl-sn-glycerol + diphosphate
    This reaction proceeds in the forward direction.
    EC:2.7.7.41 (UniProtKB | ENZYME | Rhea)

Pathway

Lipid metabolism.
Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionphosphatidate cytidylyltransferase activity
Biological Processangiogenesis
Biological ProcessCDP-diacylglycerol biosynthetic process
Biological Processpositive regulation of ERK1 and ERK2 cascade
Biological Processpositive regulation of vascular endothelial growth factor signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphatidate cytidylyltransferase
  • EC number

Gene names

    • Name
      cds2
    • Synonyms
      zgc:66134

Organism names

  • Taxonomic identifier
  • Strain
    • AB
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q7SXP9

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane68-87Helical
Transmembrane93-116Helical
Transmembrane123-140Helical
Transmembrane167-185Helical
Transmembrane192-214Helical
Transmembrane220-241Helical
Transmembrane262-286Helical
Transmembrane334-356Helical

Keywords

  • Cellular component

Family & Domains

Features

Showing features for compositional bias, region.

TypeIDPosition(s)Description
Compositional bias1-45Basic and acidic residues
Region1-48Disordered

Sequence similarities

Belongs to the CDS family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    444
  • Mass (Da)
    51,067
  • Last updated
    2003-10-01 v1
  • Checksum
    E920DAEA1C96F6DE
MAELRQRGATDKELKHQHSEDKGSETEGKERDGASDSETKPEVPVSADDTPEVLNKALSGLSSRWKNWWVRGILTLAMISFFFFIIYLGPMVLMMIVLCVQIKCFQEIITIGYSVYHSYDLPWFRTLSWYFLLCVNYFFYGETVTDYFFTLVQREEPLRILSKYHRFISFALYLTGFCMFVLSLVKKHYRLQFYMFGWTHVTLLIVVTQSHLIIHNLFEGMIWFIVPISCVICNDIMAYMFGFFFGRTPLIKLSPKKTWEGFIGGFFSTIVFGILLSYVMAGYSYFVCPVEFNNDSNRFTVDCQPSELFQLQDYSLPSVLQSITGWTTVKLYPFQIHSIALSSFASIMGPFGGFFASGFKRAFKIKDFANTIPGHGGIMDRFDCQYLMATFVNVYIASFIRGPNPSKVIQQLLALRPDQQLHIFNSLKAHLTEKGLLPALEEAA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-45Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BC055505
EMBL· GenBank· DDBJ
AAH55505.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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