Q7SXP9 · Q7SXP9_DANRE
- ProteinPhosphatidate cytidylyltransferase
- Genecds2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids444 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.
Catalytic activity
- 1,2-di-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + CTP + H+ = 1,2-di-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphateThis reaction proceeds in the forward direction.
- 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H+ = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphateThis reaction proceeds in the forward direction.
- 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H+ = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphateThis reaction proceeds in the forward direction.
- 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H+ = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphateThis reaction proceeds in the forward direction.
- 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CTP + H+ = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphateThis reaction proceeds in the forward direction.
- 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H+ = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphateThis reaction proceeds in the forward direction.
- 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CTP + H+ = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphateThis reaction proceeds in the forward direction.
- 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CTP + H+ = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphateThis reaction proceeds in the forward direction.
Pathway
Lipid metabolism.
Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | phosphatidate cytidylyltransferase activity | |
Biological Process | angiogenesis | |
Biological Process | CDP-diacylglycerol biosynthetic process | |
Biological Process | positive regulation of ERK1 and ERK2 cascade | |
Biological Process | positive regulation of vascular endothelial growth factor signaling pathway |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidate cytidylyltransferase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ7SXP9
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 68-87 | Helical | ||||
Sequence: WWVRGILTLAMISFFFFIIY | ||||||
Transmembrane | 93-116 | Helical | ||||
Sequence: LMMIVLCVQIKCFQEIITIGYSVY | ||||||
Transmembrane | 123-140 | Helical | ||||
Sequence: WFRTLSWYFLLCVNYFFY | ||||||
Transmembrane | 167-185 | Helical | ||||
Sequence: FISFALYLTGFCMFVLSLV | ||||||
Transmembrane | 192-214 | Helical | ||||
Sequence: QFYMFGWTHVTLLIVVTQSHLII | ||||||
Transmembrane | 220-241 | Helical | ||||
Sequence: GMIWFIVPISCVICNDIMAYMF | ||||||
Transmembrane | 262-286 | Helical | ||||
Sequence: FIGGFFSTIVFGILLSYVMAGYSYF | ||||||
Transmembrane | 334-356 | Helical | ||||
Sequence: FQIHSIALSSFASIMGPFGGFFA |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-45 | Basic and acidic residues | ||||
Sequence: MAELRQRGATDKELKHQHSEDKGSETEGKERDGASDSETKPEVPV | ||||||
Region | 1-48 | Disordered | ||||
Sequence: MAELRQRGATDKELKHQHSEDKGSETEGKERDGASDSETKPEVPVSAD |
Sequence similarities
Belongs to the CDS family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length444
- Mass (Da)51,067
- Last updated2003-10-01 v1
- ChecksumE920DAEA1C96F6DE
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-45 | Basic and acidic residues | ||||
Sequence: MAELRQRGATDKELKHQHSEDKGSETEGKERDGASDSETKPEVPV |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC055505 EMBL· GenBank· DDBJ | AAH55505.1 EMBL· GenBank· DDBJ | mRNA |