Q7SXN4 · CPEB4_DANRE
- ProteinCytoplasmic polyadenylation element-binding protein 4
- Genecpeb4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids635 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Sequence-specific RNA-binding protein that binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | dendrite | |
Cellular Component | dendritic spine | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | growth cone | |
Cellular Component | neuron projection | |
Cellular Component | nucleus | |
Cellular Component | perinuclear region of cytoplasm | |
Cellular Component | postsynaptic density | |
Cellular Component | synapse | |
Molecular Function | mRNA 3'-UTR binding | |
Molecular Function | mRNA regulatory element binding translation repressor activity | |
Molecular Function | ribosome binding | |
Molecular Function | translation factor activity, RNA binding | |
Biological Process | cellular response to amino acid stimulus | |
Biological Process | cellular response to decreased oxygen levels | |
Biological Process | cellular response to glucose starvation | |
Biological Process | ionotropic glutamate receptor signaling pathway | |
Biological Process | negative regulation of cytoplasmic translation | |
Biological Process | negative regulation of neuron apoptotic process | |
Biological Process | response to ischemia |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameCytoplasmic polyadenylation element-binding protein 4
- Short namesCPE-BP4; CPE-binding protein 4; CPEB-4
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ7SXN4
Proteomes
Organism-specific databases
Subcellular Location
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000269266 | 1-635 | Cytoplasmic polyadenylation element-binding protein 4 | ||
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 1-70 | Disordered | |||
Compositional bias | 11-31 | Polar residues | |||
Region | 149-284 | Disordered | |||
Compositional bias | 199-236 | Polar residues | |||
Compositional bias | 257-284 | Polar residues | |||
Compositional bias | 337-351 | Basic and acidic residues | |||
Region | 337-369 | Disordered | |||
Domain | 378-469 | RRM 1 | |||
Domain | 486-568 | RRM 2 | |||
Sequence similarities
Belongs to the RRM CPEB family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length635
- Mass (Da)70,733
- Last updated2003-10-01 v1
- Checksum7D49E294200D94BF
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M6Z9E0 | A0A8M6Z9E0_DANRE | cpeb4a | 519 | ||
A0A8M3AHT9 | A0A8M3AHT9_DANRE | cpeb4a | 711 | ||
A0A8M6Z2L6 | A0A8M6Z2L6_DANRE | cpeb4a | 511 | ||
F1QCY1 | F1QCY1_DANRE | cpeb4a | 703 |
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 11-31 | Polar residues | |||
Compositional bias | 199-236 | Polar residues | |||
Compositional bias | 257-284 | Polar residues | |||
Compositional bias | 337-351 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BC055522 EMBL· GenBank· DDBJ | AAH55522.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |