Q7SXL3 · TBP_DANRE

Function

function

General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II (By similarity).
Members of the TBP family are differentially required for transcription and development during early embryogenesis. Regulates mRNA levels in the early embryo by both transcriptional and post-transcriptional mechanisms. Required for transcription of a subset of genes at the mid-blastula transition (MBT). Negatively regulates the expression of other embryonic genes, including autoregulation of the tbp promoter itself. Also functions within a transcription-dependent mechanism to direct the temporally-regulated degradation of a subset of maternal mRNAs after the MBT. This is part of a general mechanism to regulate the maternal to zygotic transition and is required for normal embryonic development. Binds to promoters of a subset of genes. Required for gastrulation

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Cellular Componenttranscription factor TFIID complex
Molecular FunctionDNA binding
Molecular FunctionRNA polymerase II general transcription initiation factor activity
Molecular FunctionRNA polymerase III general transcription initiation factor activity
Biological ProcessDNA-templated transcription initiation
Biological Processgastrulation
Biological ProcessmRNA catabolic process
Biological Processtranscription by RNA polymerase II
Biological Processtranscription by RNA polymerase III

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    TATA-box-binding protein
  • Short names
    zTBP
  • Alternative names
    • TATA sequence-binding protein
    • TATA-binding factor
    • TATA-box factor
      (zfTBF
      )
    • Transcription initiation factor TFIID TBP subunit

Gene names

    • Name
      tbp
    • ORF names
      si:ch211-202m22.5

Organism names

  • Taxonomic identifier
  • Strains
    • Tuebingen
    • SJD
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q7SXL3
  • Secondary accessions
    • Q71H62

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003486081-302TATA-box-binding protein

Proteomic databases

Expression

Tissue specificity

Enriched in testis but hardly detectable in the ovary (at protein level).

Developmental stage

Expressed both maternally and zygotically. Expression is very low in the zygote, increasing from morula stage onward to reach a peak during early gastrulation. Levels then rapidly decline during neurula and organogenesis stages (at protein level). There is an inverse correlation between mRNA and protein levels at the late blastula and early gastrula stages.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, repeat.

TypeIDPosition(s)Description
Region1-22Disordered
Region50-81Disordered
Repeat128-2041
Repeat218-2952

Sequence similarities

Belongs to the TBP family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    302
  • Mass (Da)
    33,019
  • Last updated
    2003-10-01 v1
  • Checksum
    C63A6C1D2F7E1D50
MEQNNSLPPFAQGLASPQGAMTPGLPIFSPMMPYGTGLTPQPVQNSNSLSLLEEQQRQQQQQQAASQQQGGMVGGSGQTPQLYHSTQAVSTTTALPGNTPLYTTPLTPMTPITPATPASESSGIVPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRGEIYEAFENIYPILKGFRKTS

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict184in Ref. 2; AAQ07596

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY168633
EMBL· GenBank· DDBJ
AAO34524.1
EMBL· GenBank· DDBJ
mRNA
AF503449
EMBL· GenBank· DDBJ
AAQ07596.1
EMBL· GenBank· DDBJ
mRNA
AL772388
EMBL· GenBank· DDBJ
CAK04406.1
EMBL· GenBank· DDBJ
Genomic DNA
BC055549
EMBL· GenBank· DDBJ
AAH55549.1
EMBL· GenBank· DDBJ
mRNA
BC065860
EMBL· GenBank· DDBJ
AAH65860.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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