Q7SIF4 · AIOA_ALCFA

  • Protein
    Arsenite oxidase subunit AioA
  • Gene
    aioA
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Involved in the detoxification of arsenic. Oxidizes As(III)O33- (arsenite) to the somewhat less toxic As(V)O43- (arsenate).

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
[3Fe-4S] cluster (UniProtKB | Rhea| CHEBI:21137 )

Note: Binds 1 [3Fe-4S] cluster per subunit.
Mo-bis(molybdopterin guanine dinucleotide) (UniProtKB | Rhea| CHEBI:60539 )

Note: Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site22[3Fe-4S] cluster (UniProtKB | ChEBI)
Binding site25[3Fe-4S] cluster (UniProtKB | ChEBI)
Binding site29[3Fe-4S] cluster (UniProtKB | ChEBI)
Site100Involved in charge transfer
Binding site196substrate
Binding site204substrate
Binding site420substrate
Binding site424substrate

GO annotations

AspectTerm
Cellular Componentoxidoreductase complex
Molecular Function3 iron, 4 sulfur cluster binding
Molecular Functionarsenate reductase (azurin) activity
Molecular Functionmetal ion binding
Molecular Functionmolybdopterin cofactor binding
Biological Processcellular respiration

Keywords

Enzyme and pathway databases

Protein family/group databases

    • 5.A.3.6.1the prokaryotic molybdopterin-containing oxidoreductase (pmo) family

Names & Taxonomy

Protein names

  • Recommended name
    Arsenite oxidase subunit AioA
  • EC number
  • Short names
    AOI
  • Alternative names
    • Arsenite oxidase Mo-pterin subunit

Gene names

    • Name
      aioA
    • Synonyms
      aoxB, asoA

Organism names

  • Taxonomic identifier
  • Strain
    • CCUG 2071 / LMG 3368 / NCIMB 8687
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Alcaligenaceae > Alcaligenes

Accessions

  • Primary accession
    Q7SIF4
  • Secondary accessions
    • Q6WB60
    • Q9R5F9

Subcellular Location

PTM/Processing

Features

Showing features for initiator methionine, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
ChainPRO_00000632402-826Arsenite oxidase subunit AioA

Interaction

Subunit

Heterodimer consisting of a large and a small subunit.

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    826
  • Mass (Da)
    92,395
  • Last updated
    2012-01-25 v2
  • Checksum
    56AFA94C70E82575
MSRPNDRITLPPANAQRTNMTCHFCIVGCGYHVYKWPELQEGGRAPEQNALGLDFRKQLPPLAVTLTPAMTNVVTEHNGRRYNIMVVPDKACVVNSGLSSTRGGKMASYMYTPTGDGKQRLKAPRLYAADQWVDTTWDHAMALYAGLIKKTLDKDGPQGVFFSCFDHGGAGGGFENTWGTGKLMFSAIQTPMVRIHNRPAYNSECHATREMGIGELNNAYEDAQLADVIWSIGNNPYESQTNYFLNHWLPNLQGATTSKKKERFPNENFPQARIIFVDPRETPSVAIARHVAGNDRVLHLAIEPGTDTALFNGLFTYVVEQGWIDKPFIEAHTKGFDDAVKTNRLSLDECSNITGVPVDMLKRAAEWSYKPKASGQAPRTMHAYEKGIIWGNDNYVIQSALLDLVIATHNVGRRGTGCVRMGGHQEGYTRPPYPGDKKIYIDQELIKGKGRIMTWWGCNNFQTSNNAQALREAILQRSAIVKQAMQKARGATTEEMVDVIYEATQNGGLFVTSINLYPTKLAEAAHLMLPAAHPGEMNLTSMNGERRIRLSEKFMDPPGTAMADCLIAARIANALRDMYQKDGKAEMAAQFEGFDWKTEEDAFNDGFRRAGQPGAPAIDSQGGSTGHLVTYDRLRKSGNNGVQLPVVSWDESKGLVGTEMLYTEGKFDTDDGKAHFKPAPWNGLPATVQQQKDKYRFWLNNGRNNEVWQTAYHDQYNSLMQERYPMAYIEMNPDDCKQLDVTGGDIVEVYNDFGSTFAMVYPVAEIKRGQTFMLFGYVNGIQGDVTTDWTDRNIIPYYKGTWGDIRKVGSMEEFKRTVSFKSRRFA

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict2-3in Ref. 2; AA sequence and 3; AA sequence
Sequence conflict40in Ref. 2; AA sequence
Sequence conflict64in Ref. 2; AA sequence
Sequence conflict78-83in Ref. 2; AA sequence
Sequence conflict119in Ref. 2; AA sequence
Sequence conflict122in Ref. 2; AA sequence
Sequence conflict131in Ref. 2; AA sequence
Sequence conflict154in Ref. 2; AA sequence
Sequence conflict793in Ref. 2; AA sequence
Sequence conflict812in Ref. 2; AA sequence
Sequence conflict826in Ref. 2; AA sequence

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY297781
EMBL· GenBank· DDBJ
AAQ19838.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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