Q7SFJ3 · SLX4_NEUCR
- ProteinStructure-specific endonuclease subunit slx4
- Geneslx4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1013 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Regulatory subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | Slx1-Slx4 complex | |
Molecular Function | 5'-flap endonuclease activity | |
Biological Process | DNA recombination | |
Biological Process | DNA repair | |
Biological Process | DNA replication |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameStructure-specific endonuclease subunit slx4
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Sordariomycetidae > Sordariales > Sordariaceae > Neurospora
Accessions
- Primary accessionQ7SFJ3
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000388034 | 1-1013 | Structure-specific endonuclease subunit slx4 | ||
Post-translational modification
Phosphorylated in response to DNA damage.
Keywords
- PTM
Proteomic databases
Interaction
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 63-263 | Disordered | |||
Compositional bias | 76-106 | Polar residues | |||
Compositional bias | 197-211 | Pro residues | |||
Compositional bias | 218-232 | Basic and acidic residues | |||
Compositional bias | 300-319 | Polar residues | |||
Region | 300-329 | Disordered | |||
Region | 374-401 | Disordered | |||
Region | 502-541 | Disordered | |||
Compositional bias | 512-534 | Basic and acidic residues | |||
Region | 555-687 | Disordered | |||
Compositional bias | 592-616 | Polar residues | |||
Compositional bias | 640-675 | Polar residues | |||
Region | 755-895 | Disordered | |||
Compositional bias | 797-842 | Polar residues | |||
Sequence similarities
Belongs to the SLX4 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,013
- Mass (Da)109,921
- Last updated2003-12-15 v1
- Checksum3A657D707A10E02C
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 76-106 | Polar residues | |||
Compositional bias | 197-211 | Pro residues | |||
Compositional bias | 218-232 | Basic and acidic residues | |||
Compositional bias | 300-319 | Polar residues | |||
Compositional bias | 512-534 | Basic and acidic residues | |||
Compositional bias | 592-616 | Polar residues | |||
Compositional bias | 640-675 | Polar residues | |||
Compositional bias | 797-842 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CM002236 EMBL· GenBank· DDBJ | EAA35600.1 EMBL· GenBank· DDBJ | Genomic DNA |