Q7SFJ3 · SLX4_NEUCR

Function

function

Regulatory subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentSlx1-Slx4 complex
Molecular Function5'-flap endonuclease activity
Biological ProcessDNA recombination
Biological ProcessDNA repair
Biological ProcessDNA replication

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Structure-specific endonuclease subunit slx4

Gene names

    • Name
      slx4
    • ORF names
      NCU08628

Organism names

Accessions

  • Primary accession
    Q7SFJ3

Proteomes

    • Identifier
    • Component
      Chromosome 1, Linkage Group I

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003880341-1013Structure-specific endonuclease subunit slx4

Post-translational modification

Phosphorylated in response to DNA damage.

Keywords

Proteomic databases

Interaction

Subunit

Forms a heterodimer with slx1.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region63-263Disordered
Compositional bias76-106Polar residues
Compositional bias197-211Pro residues
Compositional bias218-232Basic and acidic residues
Compositional bias300-319Polar residues
Region300-329Disordered
Region374-401Disordered
Region502-541Disordered
Compositional bias512-534Basic and acidic residues
Region555-687Disordered
Compositional bias592-616Polar residues
Compositional bias640-675Polar residues
Region755-895Disordered
Compositional bias797-842Polar residues

Sequence similarities

Belongs to the SLX4 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,013
  • Mass (Da)
    109,921
  • Last updated
    2003-12-15 v1
  • Checksum
    3A657D707A10E02C
MAHNDTIDIISSSPEFPDISVLVAKAASKKSALRTGSNATPIPSDAVGLGTFTSAASIWHLSQVMDEEKPTKNSSSRPAKETPAIATSVSTVAVEVSATTTTAVSEEKPGKKPRKPRKKKDETTAAVDENAPPKPPARRGRPPKQKDVEGQPALPKSKATKPAAKPRASRKKAETVSKHFAASAHASTADPPEEPSKNPAASKPPKPIPVQNIDEPVDLEPAARRRLDWTPPPDDRPPPAAGNSSVVKELPSSTTAHTEPPVAFGKLLDTYGCEPETIQPSEGTKGNVLGKRKLIEMVATTTTTNTATDKLTSPETSPTKPKAPKKKPRTITDLATAAYRIQDPVDDSISTVAPKQDTLLGYIDVEDEDAAVKPGGAKTKAVSKKPAKARVSKKKPEPRKQLLLSPHSALRQVSGQNFVFGTSSQLVTEDTDLLRALHESMKTAGNAQESDPFMSSPVKFSNIASRSKMGNNKLWRVGARDEDGDLLDLEIFDLTEAVEVPEDVVQQADKPAVDVPEREASPRKQVEREAERAIGIFSSDPVATERLTITGPETLISTLSIKGKESVRRTTKSPPPNPVAPPRERTPQRARPPSRDSLSSRLRSPQTETSPRPTTPPRVSAVLDLDYDFDDYEPPPSNQEHYQLLEQSQKTSPSKTQQRKQQQQQQQQQQQQQKKRDPPPRPKYEVFTDAQLSREIASYGFKPIKKRAAMIRLLEQCWESKTGAATGKSTGLGDNTLQEGTGSLEPAHRSINSVAVSPDRGRGQTIQGAHMQEARAGIKMAASATKRPRKKAAVASASAPRTSTMENPPKAATAASTSTTTAPLPALSASTSKRQRRTSLSSIRPRPPILEIPDSDIDISDSDPFASSPPVSSPDASPPASQLFSTPEKHHQDHKHDLAAEMSLITDCEESLLDMTSRTPSEADLFKHITEAITTAPRTTNPSEPSWHEKILMYDPIILEELTAWLNTAGKGLDRVGWEGCEAGTEEVRRWCESKGVGWVWREGNRGQVRKRF

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias76-106Polar residues
Compositional bias197-211Pro residues
Compositional bias218-232Basic and acidic residues
Compositional bias300-319Polar residues
Compositional bias512-534Basic and acidic residues
Compositional bias592-616Polar residues
Compositional bias640-675Polar residues
Compositional bias797-842Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM002236
EMBL· GenBank· DDBJ
EAA35600.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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