Q7SAJ6 · CHO2_NEUCR
- ProteinPhosphatidylethanolamine N-methyltransferase
- Genechol-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids965 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + H+ + S-adenosyl-L-homocysteine
Pathway
Phospholipid metabolism; phosphatidylcholine biosynthesis.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cortical endoplasmic reticulum | |
Cellular Component | endoplasmic reticulum membrane | |
Cellular Component | perinuclear endoplasmic reticulum | |
Molecular Function | phosphatidylethanolamine N-methyltransferase activity | |
Biological Process | methylation | |
Biological Process | phosphatidylcholine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidylethanolamine N-methyltransferase
- EC number
- Short namesPE methyltransferase ; PEAMT ; PEMT
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Sordariomycetidae > Sordariales > Sordariaceae > Neurospora
Accessions
- Primary accessionQ7SAJ6
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-91 | Lumenal | ||||
Sequence: MSSSAADPFAARLNSDVRQRHPTASATSKNVEGTSQQKQQQQQQQSEANAAASRVKKTYGKTPDGTVFVVPTTHDMVTQLLDPREPKNLSD | ||||||
Transmembrane | 92-112 | Helical | ||||
Sequence: VAVLAIIALHFLAAYYLPWGV | ||||||
Topological domain | 113-115 | Cytoplasmic | ||||
Sequence: KRP | ||||||
Transmembrane | 116-136 | Helical | ||||
Sequence: LFAAIFMFWRLAYNVGIGYLL | ||||||
Topological domain | 137-201 | Lumenal | ||||
Sequence: TIQSKYKLLVTWAKRWKLFENPATGKNPRPWLYNLLKKELETKIPQDYKFEEAPIEYNTWLTFRR | ||||||
Transmembrane | 202-222 | Helical | ||||
Sequence: VVDLILMCDFISYCLFAIVCA | ||||||
Topological domain | 223-229 | Cytoplasmic | ||||
Sequence: HKPDGEG | ||||||
Transmembrane | 230-250 | Helical | ||||
Sequence: LFMCFARWAAGITLVGFNLWV | ||||||
Topological domain | 251-279 | Lumenal | ||||
Sequence: KLDAHRVVKDYAWYWGDFFYLIEQELTFD | ||||||
Transmembrane | 280-300 | Helical | ||||
Sequence: GVFELAPHPMYSIGYAGYYGI | ||||||
Topological domain | 301-306 | Cytoplasmic | ||||
Sequence: SMMAAS | ||||||
Transmembrane | 307-327 | Helical | ||||
Sequence: YDVLFISIIAHAAQFAFLVIV | ||||||
Topological domain | 328-389 | Lumenal | ||||
Sequence: ENPHIEKTYNPPQPRVRCESEAGSQLQEFASEYSVPSTTGRHDNTPLPVHNLIGLKNLDFFR | ||||||
Transmembrane | 390-410 | Helical | ||||
Sequence: ITDVAIVLLCAYLAVVTMVTP | ||||||
Topological domain | 411-417 | Cytoplasmic | ||||
Sequence: NTRFYQA | ||||||
Transmembrane | 418-438 | Helical | ||||
Sequence: LFVLHALAWRLWYSAGLGVIL | ||||||
Topological domain | 439-467 | Lumenal | ||||
Sequence: TMQSEEKMFTRHFLKYGESVGEAWRQWKG | ||||||
Transmembrane | 468-488 | Helical | ||||
Sequence: IYHLSNCLCHASFIAASYKMY | ||||||
Topological domain | 489-496 | Cytoplasmic | ||||
Sequence: EFPADWTY | ||||||
Transmembrane | 497-517 | Helical | ||||
Sequence: GWALLKHVVGLSLIALQVWTA | ||||||
Topological domain | 518-573 | Lumenal | ||||
Sequence: TSIYESLGEFGWFYGDFFFDSKRQLTYTSIYRFLNNPERVFGTAGLWGAALITWSR | ||||||
Transmembrane | 574-594 | Helical | ||||
Sequence: AIFLMALAGHFLTLAFLAYVE | ||||||
Topological domain | 595-965 | Cytoplasmic | ||||
Sequence: KPHMQKVYGRNLRDDAGVTKFIKRSLPPPVTEWQQSIDKVLDETKHFIDEFVDAARSRLATGSSTIVKDTSALFNKYPARLTLSKISPDLAGYDPKHYGLSLAGTRVVGTNEKATGKESPNARVLKDVKTQAFEYGAPIRVKWTAPANHSKKDWVGLYMVTDNRSREVTEVPSLGRWVPTNPGEYDTTTDQGILVWDQPVEKKSEDTDLVEGEMVFEGDKLWWTQGVFEFRYHHGGGHHVMSISEPFEIQIPKFDDEHMGVDISGEVGERAVEAALLPVIRNCLDRDPDIAPSNAEERFGGHVERDGKYARRVVYAIRHMFGIDFAPAVVLADGNVRRLAWRICHAKEVLAPFSMSHTNGRTTPVDSKFSE |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000405900 | 1-965 | Phosphatidylethanolamine N-methyltransferase | |||
Sequence: MSSSAADPFAARLNSDVRQRHPTASATSKNVEGTSQQKQQQQQQQSEANAAASRVKKTYGKTPDGTVFVVPTTHDMVTQLLDPREPKNLSDVAVLAIIALHFLAAYYLPWGVKRPLFAAIFMFWRLAYNVGIGYLLTIQSKYKLLVTWAKRWKLFENPATGKNPRPWLYNLLKKELETKIPQDYKFEEAPIEYNTWLTFRRVVDLILMCDFISYCLFAIVCAHKPDGEGLFMCFARWAAGITLVGFNLWVKLDAHRVVKDYAWYWGDFFYLIEQELTFDGVFELAPHPMYSIGYAGYYGISMMAASYDVLFISIIAHAAQFAFLVIVENPHIEKTYNPPQPRVRCESEAGSQLQEFASEYSVPSTTGRHDNTPLPVHNLIGLKNLDFFRITDVAIVLLCAYLAVVTMVTPNTRFYQALFVLHALAWRLWYSAGLGVILTMQSEEKMFTRHFLKYGESVGEAWRQWKGIYHLSNCLCHASFIAASYKMYEFPADWTYGWALLKHVVGLSLIALQVWTATSIYESLGEFGWFYGDFFFDSKRQLTYTSIYRFLNNPERVFGTAGLWGAALITWSRAIFLMALAGHFLTLAFLAYVEKPHMQKVYGRNLRDDAGVTKFIKRSLPPPVTEWQQSIDKVLDETKHFIDEFVDAARSRLATGSSTIVKDTSALFNKYPARLTLSKISPDLAGYDPKHYGLSLAGTRVVGTNEKATGKESPNARVLKDVKTQAFEYGAPIRVKWTAPANHSKKDWVGLYMVTDNRSREVTEVPSLGRWVPTNPGEYDTTTDQGILVWDQPVEKKSEDTDLVEGEMVFEGDKLWWTQGVFEFRYHHGGGHHVMSISEPFEIQIPKFDDEHMGVDISGEVGERAVEAALLPVIRNCLDRDPDIAPSNAEERFGGHVERDGKYARRVVYAIRHMFGIDFAPAVVLADGNVRRLAWRICHAKEVLAPFSMSHTNGRTTPVDSKFSE |
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-55 | Disordered | ||||
Sequence: MSSSAADPFAARLNSDVRQRHPTASATSKNVEGTSQQKQQQQQQQSEANAAASRV | ||||||
Compositional bias | 18-52 | Polar residues | ||||
Sequence: RQRHPTASATSKNVEGTSQQKQQQQQQQSEANAAA |
Sequence similarities
Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length965
- Mass (Da)109,552
- Last updated2003-12-15 v1
- ChecksumEAA3EF9E29E795FE
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 18-52 | Polar residues | ||||
Sequence: RQRHPTASATSKNVEGTSQQKQQQQQQQSEANAAA |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX897675 EMBL· GenBank· DDBJ | CAE85544.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CM002239 EMBL· GenBank· DDBJ | EAA33479.1 EMBL· GenBank· DDBJ | Genomic DNA |