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Q7S6N6 · PABP_NEUCR

Function

function

Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasmic stress granule
Cellular Componentcytosol
Cellular Componentnucleus
Cellular Componentribonucleoprotein complex
Molecular FunctionmRNA 3'-UTR binding
Molecular Functionpoly(A) binding
Molecular Functionpoly(U) RNA binding
Biological ProcessmRNA processing
Biological ProcessmRNA transport
Biological Processregulation of translation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Polyadenylate-binding protein, cytoplasmic and nuclear
  • Short names
    PABP; Poly(A)-binding protein
  • Alternative names
    • Polyadenylate tail-binding protein

Gene names

    • Name
      pabp-1
    • Synonyms
      pab1
    • ORF names
      NCU04799

Organism names

Accessions

  • Primary accession
    Q7S6N6

Proteomes

    • Identifier
    • Component
      Chromosome 5, Linkage Group VI

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002953961-764Polyadenylate-binding protein, cytoplasmic and nuclear

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, domain, compositional bias.

Type
IDPosition(s)Description
Region36-56Disordered
Domain60-138RRM 1
Domain148-225RRM 2
Domain241-318RRM 3
Domain344-462RRM 4
Region375-420Disordered
Compositional bias379-420Basic and acidic residues
Region587-634Disordered
Domain657-734PABC
Region735-764Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    764
  • Mass (Da)
    82,317
  • Last updated
    2003-12-15 v1
  • MD5 Checksum
    E2F1ED6892CEB19475EB9142F200CCB2
MAATSTAAVDQLAADLGNTSLDNKAAAPAPIDTSAVPEAQAEGAEAAPTPTAAPHPQASASLYVGELDPSVTEAMLFELFSQIGSVASIRVCRDAVTRRSLGYAYVNYNTTADGEKALEELNYTLIKGRPCRIMWSQRDPALRKTGAGNIFIKNLDAAIDNKALHDTFAAFGNILSCKVAQDEHGNSKGYGFVHYETDEAASQAIKHVNGMLLNEKKVYVGHHIPKKDRQSKFEEMKANFTNVYVKNINNEVTDEEFRELFAKFGEVTSSSLARDQEGKSRGFGFVNFTTHEAAAQAVDELNGKDFRGQDLYVGRAQKKHEREEELRKSYEAARLEKANKYQGVNLYIKNLGDDVDDDKLRAMFSEYGPITSAKVMRDSLIEGSEEKDEKDKENKKEGETKEEEQNEGSEKKTEKKGDRKLGKSKGFGFVCFSNPDDATKAVTEMNQRMVDGKPLYVALAQRKDVRKSQLEASIQARNQLRMQQAAAQAGMPQQYMQAPVYYAGQQPGFMPAPGGRGVPFPQGGIVPGVQGGRPGQYPYQQGGRGGVPPQQMPPMGYPINQFGPGAFPPNTPQYMAAMGQVGALGGGRGGPAGRGPQGIPAGIPQGLQGGPAVPGYPPAGRPQNGGGRGTPRGNANFMAAGRGASPIPGAPADLSAGSFLQAQLATTQDPQAQKQIIGENLFPKIQAIQPALAGKITGMLLEMDNAELINLFEDDNALNVKVQEALAVYDEYLKTQGQQPTQQPAEANGEQPKAEEQKPEEQKA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias379-420Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM002241
EMBL· GenBank· DDBJ
EAA31189.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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