Essential maintenance is planned to begin on Fri Jan 24 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ in case of any outage.

Q7S6F3 · DBP9_NEUCR

Function

function

ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.

Catalytic activity

Features

Showing features for binding site.

167650100150200250300350400450500550600650
TypeIDPosition(s)Description
Binding site139-146ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnucleolus
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionDNA helicase activity
Molecular FunctionDNA/RNA helicase activity
Molecular FunctionRNA binding
Molecular FunctionRNA helicase activity
Biological Processmaturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent RNA helicase dbp-9
  • EC number

Gene names

    • Name
      dbp-9
    • ORF names
      NCU07070

Organism names

Accessions

  • Primary accession
    Q7S6F3

Proteomes

    • Identifier
    • Component
      Chromosome 5, Linkage Group VI

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002323441-676ATP-dependent RNA helicase dbp-9

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, motif, domain.

Type
IDPosition(s)Description
Region1-97Disordered
Compositional bias23-47Basic and acidic residues
Compositional bias48-65Polar residues
Compositional bias66-97Basic and acidic residues
Motif95-123Q motif
Domain126-304Helicase ATP-binding
Motif251-254DEAD box
Domain317-541Helicase C-terminal
Region410-444Disordered
Region633-676Disordered
Compositional bias646-676Basic residues

Domain

The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    676
  • Mass (Da)
    76,617
  • Last updated
    2003-12-15 v1
  • MD5 Checksum
    E90C62C8D9A2D657296B9875B9285780
MAKRKLNETDEPSVVTEPQTQKKTKKSSTEKKEKKEKKSKSQSVKPQEEKPEATQQQAQQQTEEEQELEQQLKDEQKQQDEKDEKKQSEKDDADLTFSDLGLDPRLVQAVAKQSFEKPTLVQRKAIPLALAGQDVLCKAKTGSGKTAAYVLPVLSGILKRKATDPTPFTSALILVPTRELADQVHKAIDAFSAFCTKDIQSAKLTDNVSDAVLRSLLANAPDVIVSTPARAWHNIESGALSVAKLQYLVLDEADLVLSYGYDEDMENIARSLPKGGVQTTMMSATLVSDELDTLKGFFCRNPTMLDLKEEFSNEDEKLTQFYVKCGEDDKWLISYLIFKLQLIKGPCLVFVADIDRAYRLKLFFEQFSIRSCVLNSELPINTRIKIIEEFNRGIYDIIIASDERSEVFLEDEKTEEKKEEQGEKKEGDEKKNGKGKKKKGRRDQEYGVSRGIDFKNVAAVINFDMPTSSSSYIHRIGRTARAGRAGIALSMVVPHDLFGKHKPTSIKQCEKDEKVLAKVMRQQAKLNRKLEPYNFNKDQMEAFRYRMNDALRAVTKVAIREARTRELRQELLRSETLKRYFEENPHELSHLRHDGELGTKMRQQAHLKHVPDYLLPQDGKNALTETQIGFVPFKKQGDDKKTRGKKGAKGGKGGHGKYKKGPGGRKNVLKTFRVRK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias23-47Basic and acidic residues
Compositional bias48-65Polar residues
Compositional bias66-97Basic and acidic residues
Compositional bias646-676Basic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM002241
EMBL· GenBank· DDBJ
EAA31099.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help