Q7S2A9 · TOF1_NEUCR
- ProteinTopoisomerase 1-associated factor 1
- Genetof-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1235 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Forms a fork protection complex (FPC) with csm-3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | replication fork protection complex | |
Molecular Function | DNA binding | |
Biological Process | DNA repair | |
Biological Process | DNA replication checkpoint signaling | |
Biological Process | meiotic cell cycle | |
Biological Process | replication fork arrest |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameTopoisomerase 1-associated factor 1
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Sordariomycetidae > Sordariales > Sordariaceae > Neurospora
Accessions
- Primary accessionQ7S2A9
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000301744 | 1-1235 | Topoisomerase 1-associated factor 1 | ||
Proteomic databases
Interaction
Subunit
Component of the fork protection complex (FPC) consisting of tof-1 and csm-3.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 327-357 | Disordered | |||
Region | 584-610 | Disordered | |||
Region | 812-841 | Disordered | |||
Region | 897-1235 | Disordered | |||
Compositional bias | 908-933 | Basic and acidic residues | |||
Compositional bias | 934-948 | Acidic residues | |||
Compositional bias | 987-1043 | Basic and acidic residues | |||
Compositional bias | 1080-1099 | Basic and acidic residues | |||
Compositional bias | 1100-1117 | Acidic residues | |||
Compositional bias | 1126-1146 | Basic residues | |||
Compositional bias | 1157-1171 | Acidic residues | |||
Sequence similarities
Belongs to the timeless family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,235
- Mass (Da)140,517
- Last updated2003-12-15 v1
- Checksum433E3344D9F4974E
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 908-933 | Basic and acidic residues | |||
Compositional bias | 934-948 | Acidic residues | |||
Compositional bias | 987-1043 | Basic and acidic residues | |||
Compositional bias | 1080-1099 | Basic and acidic residues | |||
Compositional bias | 1100-1117 | Acidic residues | |||
Compositional bias | 1126-1146 | Basic residues | |||
Compositional bias | 1157-1171 | Acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX842620 EMBL· GenBank· DDBJ | CAE76157.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CM002240 EMBL· GenBank· DDBJ | EAA29535.1 EMBL· GenBank· DDBJ | Genomic DNA |