Using homology modeling molecular docking and molecular dynamics (MD) simulations this study investigates the effects of five natural umami ligands on the structural dynamics of T1R1-T1R3.
The data further reveal that the C terminus of the extracellular cysteine-rich domain needs to be properly folded for T1R3 dimerization and co-trafficking but not for surface expression of T1R2 alone. These results guided the modeling of the T1R2-T1R3 dimer in living cells.
Studied association of taste 1 receptor member 1 (TAS1R1) and taste 1 receptor member 3 (TAS1R3) single nucleotide polymorphisms (SNPs) with food choices at a buffet meal. and found certain TAS1R1 and TAS1R3 SNPs to be associated with fat and savoury-tasting and protein-rich food choices following a laboratory buffet in humans.
These studies are the first to demonstrate a protective effect of an artificial sweetener through the sweet taste receptor T1R3 on VEGF-induced vasculogenesis in a retinal microvascular endothelial cell line.
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