Q7Q2T8 · AMPN_ANOGA

Function

Catalytic activity

  • Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.
    EC:3.4.11.2 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Biotechnology

Potential vaccine candidate (PubMed:26075520).
Antibodies against ANP1 prevent parasite P.falciparum development in the mosquito midgut (PubMed:26075520).

pH Dependence

Optimum pH is 6-7.5.

Features

Showing features for binding site, active site, site.

Type
IDPosition(s)Description
Binding site199substrate
Binding site330substrate
Binding site331substrate
Binding site333substrate
Binding site366substrate
Binding site366Zn2+ (UniProtKB | ChEBI); catalytic
Active site367
Binding site370Zn2+ (UniProtKB | ChEBI); catalytic
Binding site389substrate
Binding site389Zn2+ (UniProtKB | ChEBI); catalytic
Site452Transition state stabilizer

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentextracellular space
Cellular Componentmembrane
Cellular Componentplasma membrane
Cellular Componentside of membrane
Molecular Functionidentical protein binding
Molecular Functionmetalloaminopeptidase activity
Molecular Functionmetallopeptidase activity
Molecular Functionpeptide binding
Molecular Functionzinc ion binding
Biological Processpeptide catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aminopeptidase N
  • EC number
  • Short names
    AnAPN1
  • Alternative names
    • Alanyl aminopeptidase N

Gene names

    • Name
      APN1
    • ORF names
      AgaP_AGAP004809

Organism names

  • Taxonomic identifier
  • Strain
    • PEST
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Anophelinae > Anopheles

Accessions

  • Primary accession
    Q7Q2T8

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, lipidation, propeptide.

Type
IDPosition(s)Description
Signal1-19
ChainPRO_501458808520-997Aminopeptidase N
Disulfide bond736↔743
Disulfide bond772↔808
Lipidation997GPI-anchor amidated aspartate
PropeptidePRO_0000457487998-1020Removed in mature form

Keywords

Proteomic databases

Interaction

Subunit

Homodimer.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY Q7Q2T8APN1 Q7Q2T82EBI-16161420, EBI-16161420

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region958-981Disordered

Sequence similarities

Belongs to the peptidase M1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    1,020
  • Mass (Da)
    113,244
  • Last updated
    2007-10-23 v4
  • MD5 Checksum
    81AE84BB1BA6AADFBC8AAA53DD559AE6
MVRLLLLVSLGLCCLLASADRPPYKSSGIYEEEPQLPGASDLSGGVASDEIGVAPAQAVDERYRLPTTSIPIHYDLHLRTEIHRNERTFTGTVGIQLQVVQATDKLVMHNRGLVMSSAKVSSLPNGVTGAPTLIGDVQYSTDTTFEHITFTSPTILQPGTYLLEVAFQGRLATNDDGFYVSSYVADNGERRYLATTQFESTSARMAFPCYDEPGLKATFTVSITHSLSYKAISNMPQKTTTDIETDMRTTFFEKTPAMSTYLLAFVVSDFQLRLSGAQRVYVRPNAFNEATFALEAGVKILKVLDDHLGIPYDTYMPKLDQIAIPDFAAGAMENWGLVTYREQALLFNPAVSTYRGKTNVATTIAHEYAHQWFGNLVSPEWWEYIWLNEGFATLYEFYALDMAYPGQEYWELFNQQVIQYAMGQDGQASTRPMNWNAATPGEISALFDRVAYDKSGSVLNMMRHVLGDDNWKAGLKAYLTDRALQGAVDEQLYAGLQSAIEGKGVLPNGVTVAQIMRTWTNEAGYPVLNVRRSYDTGDVIISQERFYNDRKVPNTNIWMIPYNYVHQAKADFNEFDDFQWLATKAARIETTVPANEWIVFNKQQVGYYRVNYDEHNWELITNALHENWASIHRLNRAQLIDDAYWLARSGRLDLRVALRFMTYLRNEREYAPWTAANVALTYFNNRLRGTAEYHNFLIFVDALIEDIYSLLTIDAVSPDDTLLHKYLVQTISTWACSMGYTDCLMKTAALLKAEASGTGPAVHPDIASVTYCYGMRSALESEFQYLYRKMMNSKNLAERTMLIDSLGCSNNKEFLKAFLTTALGSGTGVEINYRADERRRVVQAIYSGGRTGVDALIEFLMDPALVNEFVSTLSTSTLNSALSAIASRTNNVEEMNKLNALITALGSRVNSQTAANLRTTAQANLDWVNGFEGLMLSNFLAEFAAETLLTTTAAPETTTVTAGPTTTTTTPSSAVTTTTGPTSVTTTVVQTTTEEDDGAATIGLSIAALLVSITVHLLMG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAAB01008968
EMBL· GenBank· DDBJ
EAA13235.4
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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