Q7PYI7 · CRY1_ANOGA
- ProteinCryptochrome-1
- GeneCry1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids545 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Blue light-dependent regulator that is the input of the circadian feedback loop. Has no photolyase activity for cyclobutane pyrimidine dimers or 6-4 photoproducts. Regulation of expression by light suggests a role in photoreception for locomotor activity rhythms. Functions, together with per, as a transcriptional repressor required for the oscillation of peripheral circadian clocks and for the correct specification of clock cells. Genes directly activated by the transcription factors Clock (Clk) and cycle (cyc) are repressed by cry (By similarity).
Cofactor
Note: Binds 1 FAD per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 237 | FAD (UniProtKB | ChEBI) | |||
Binding site | 265 | FAD (UniProtKB | ChEBI) | |||
Binding site | 267 | FAD (UniProtKB | ChEBI) | |||
Binding site | 308 | FAD (UniProtKB | ChEBI) | |||
Binding site | 375 | FAD (UniProtKB | ChEBI) | |||
Binding site | 407-409 | FAD (UniProtKB | ChEBI) | |||
Binding site | 413 | FAD (UniProtKB | ChEBI) | |||
Binding site | 416 | FAD (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Cellular Component | perinuclear region of cytoplasm | |
Molecular Function | blue light photoreceptor activity | |
Molecular Function | DNA binding | |
Molecular Function | FAD binding | |
Molecular Function | flavin adenine dinucleotide binding | |
Biological Process | circadian regulation of gene expression | |
Biological Process | entrainment of circadian clock by photoperiod | |
Biological Process | negative regulation of DNA-templated transcription | |
Biological Process | nucleobase-containing compound metabolic process | |
Biological Process | regulation of circadian rhythm | |
Biological Process | response to stress |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCryptochrome-1
- Short namesagCRY1
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Anophelinae > Anopheles
Accessions
- Primary accessionQ7PYI7
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Nuclear translocation initiates after the perception of a light signal.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000348594 | 1-545 | Cryptochrome-1 | ||
Proteomic databases
Interaction
Subunit
Interacts with tim and per; promoted by light conditions.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 3-140 | Photolyase/cryptochrome alpha/beta | |||
Domain
FAD-binding region regulates cry stability, cry-tim interaction, and circadian photosensitivity.
Photolyase/cryptochrome alpha/beta domain is sufficient for light detection and phototransduction.
Sequence similarities
Belongs to the DNA photolyase class-1 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length545
- Mass (Da)62,497
- Last updated2007-10-23 v4
- Checksum88814BF4D3945D2E
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
DQ219482 EMBL· GenBank· DDBJ | ABB29886.1 EMBL· GenBank· DDBJ | mRNA | ||
AAAB01008987 EMBL· GenBank· DDBJ | EAA01270.4 EMBL· GenBank· DDBJ | Genomic DNA |