Q7PYI7 · CRY1_ANOGA

Function

function

Blue light-dependent regulator that is the input of the circadian feedback loop. Has no photolyase activity for cyclobutane pyrimidine dimers or 6-4 photoproducts. Regulation of expression by light suggests a role in photoreception for locomotor activity rhythms. Functions, together with per, as a transcriptional repressor required for the oscillation of peripheral circadian clocks and for the correct specification of clock cells. Genes directly activated by the transcription factors Clock (Clk) and cycle (cyc) are repressed by cry (By similarity).

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD per subunit.

Features

Showing features for binding site.

154550100150200250300350400450500
TypeIDPosition(s)Description
Binding site237FAD (UniProtKB | ChEBI)
Binding site265FAD (UniProtKB | ChEBI)
Binding site267FAD (UniProtKB | ChEBI)
Binding site308FAD (UniProtKB | ChEBI)
Binding site375FAD (UniProtKB | ChEBI)
Binding site407-409FAD (UniProtKB | ChEBI)
Binding site413FAD (UniProtKB | ChEBI)
Binding site416FAD (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Cellular Componentperinuclear region of cytoplasm
Molecular Functionblue light photoreceptor activity
Molecular FunctionDNA binding
Molecular FunctionFAD binding
Molecular Functionflavin adenine dinucleotide binding
Biological Processcircadian regulation of gene expression
Biological Processentrainment of circadian clock by photoperiod
Biological Processnegative regulation of DNA-templated transcription
Biological Processnucleobase-containing compound metabolic process
Biological Processregulation of circadian rhythm
Biological Processresponse to stress

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cryptochrome-1
  • Short names
    agCRY1

Gene names

    • Name
      Cry1
    • ORF names
      AGAP001958

Organism names

  • Taxonomic identifier
  • Strain
    • PEST
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Anophelinae > Anopheles

Accessions

  • Primary accession
    Q7PYI7
  • Secondary accessions
    • Q0QW08

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Nucleus
Note: Nuclear translocation initiates after the perception of a light signal.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003485941-545Cryptochrome-1

Proteomic databases

Interaction

Subunit

Interacts with tim and per; promoted by light conditions.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain3-140Photolyase/cryptochrome alpha/beta

Domain

FAD-binding region regulates cry stability, cry-tim interaction, and circadian photosensitivity.
Photolyase/cryptochrome alpha/beta domain is sufficient for light detection and phototransduction.

Sequence similarities

Belongs to the DNA photolyase class-1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    545
  • Mass (Da)
    62,497
  • Last updated
    2007-10-23 v4
  • Checksum
    88814BF4D3945D2E
MTINNILWFRHGLRLHDNPSLLEALKSDCVNQSSEAVKLFPIFIFDGESAGTRIVGYNRMKFLLESLADLDRQFRDLGGQLLVFRGDSVTVLRRLFEELNIKKLCYEQDCEPIWKERDDAVAKLCRTMDVRCVENVSHTLWNPIEVIQTNGDIPPLTYQMFLHTVNIIGDPPRPVGAPNFEYVEFGRVPALLASELKLCQQMPAPDDFGIHYDGNARIAFQKWIGGETRALEALGARLKQEEEAFREGYYLPTQAKPEILGPATSMSAALRFGCLSVRMFYWCVHDLFAKVQSNSQFKYPGGHHITGQLIWREYFYTMSVQNPHYGEMERNPICLNIPWYKPEDDSLTRWKEGRTGFPMIDAAMRQLLAEGWLHHILRNITATFLTRGGLWLSWEEGLQHFLKYLLDADWSVCAGNWMWVSSSAFERLLDSSKCTCPIALARRLDPKGDYVKRYLPELANYPAQFVHEPWKASREQQIEYGCVIGEKYPAPMVDLAIVSKRNAHTMASLREKLVDGGSTPPHCRPSDIEEIRQFFWLADDAATEA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ219482
EMBL· GenBank· DDBJ
ABB29886.1
EMBL· GenBank· DDBJ
mRNA
AAAB01008987
EMBL· GenBank· DDBJ
EAA01270.4
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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