Q7NXI6 · RRAAH_CHRVO

Function

function

Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Divalent metal cation.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site75-78substrate
Binding site97substrate
Binding site98a divalent metal cation (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4-hydroxy-4-methyl-2-oxoglutarate aldolase activity
Molecular Functionmetal ion binding
Molecular Functionoxaloacetate decarboxylase activity
Molecular Functionribonuclease inhibitor activity
Biological Processregulation of RNA metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase
  • EC number
  • Short names
    HMG aldolase
  • Alternative names
    • Oxaloacetate decarboxylase (OAA decarboxylase) (EC:4.1.1.112) . EC:4.1.1.112 (UniProtKB | ENZYME | Rhea)
    • Regulator of ribonuclease activity homolog
    • RraA-like protein

Gene names

    • Ordered locus names
      CV_1640

Organism names

Accessions

  • Primary accession
    Q7NXI6

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002096071-159Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase

Interaction

Subunit

Homotrimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the class II aldolase/RraA-like family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    159
  • Mass (Da)
    16,772
  • Last updated
    2003-12-15 v1
  • Checksum
    0364083114A98C2A
MSLATTDLCDAFDAEIQVLDPVFQSFGGHARFHGPIATLKLFEDNSLVRQMLGEPGNGRVLVVDGGGSRRCALLGDQLGELAVKNGWAGLVIDGCVRDSAALGKLPLGVKALAAHPRKSVKRDSGQRDLPLRVAGCDILPGQWLYADEDGVIVSGRPLG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE016825
EMBL· GenBank· DDBJ
AAQ59316.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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