Q7NIR8 · Q7NIR8_GLOVI

Function

function

Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N1-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site16Nucleophile
Binding site252[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site299Mg2+ (UniProtKB | ChEBI)
Binding site361Mg2+ (UniProtKB | ChEBI)
Binding site362Mg2+ (UniProtKB | ChEBI)
Binding site398[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site449[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site452[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionamidophosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Biological Process'de novo' IMP biosynthetic process
Biological Processpurine nucleobase biosynthetic process
Biological Processpurine nucleotide biosynthetic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Amidophosphoribosyltransferase
  • EC number
  • Short names
    ATase
  • Alternative names
    • Glutamine phosphoribosylpyrophosphate amidotransferase
      (GPATase
      )

Gene names

    • Name
      purF

Organism names

Accessions

  • Primary accession
    Q7NIR8

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain16-237Glutamine amidotransferase type-2

Sequence similarities

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    478
  • Mass (Da)
    51,766
  • Last updated
    2003-12-15 v1
  • MD5 Checksum
    0C6FAAF74F0BE40074549673470354A1
MTYAAPSAPDKPEEACGVFGILAPGEAVAKLTYFGLFALQHRGQESAGIAVLDGDRLTMHKDMGLVSQVFDEALLNELQGQLAVGHTRYSTTGSSRKVNAQPVVSRTRLGPVVLAHNGNLVNAAQLREELLAREHTLLATTDSEEIVHAIGEAVDDGKGWVEGTVHALKRCRGAFSLVIGTPAGLMGTRDANGVRPLVIGTLKGRYVLASETCALSIIGAKYLRDVEPGELVFITESGLESHHWAKPEPRMCIFEMIYFARPDSRVNAESLYTYRERLGEILAQEAPVEADVVIPVPDSGTPAAIGYARASGILFQQGLIKNHYVGRTFIQPTQTMREAGIKMKLNPLPDVIEGKRIVIVDDSIVRGTTSRKIVQALRDSGAREVHMRISSPPVTHPCFYGIDTDSQDQLIAATKSVDEIARHIEVDSLAYLSVEGMLKATRTDGQGFCTACFTGDYPIPIPDAIRRTKLVLEKTAAS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BA000045
EMBL· GenBank· DDBJ
BAC90055.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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