Q7N7H2 · IXTPA_PHOLL

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site8-13substrate
Binding site40Mg2+ (UniProtKB | ChEBI)
Active site69Proton acceptor
Binding site69Mg2+ (UniProtKB | ChEBI)
Binding site70substrate
Binding site154-157substrate
Binding site177substrate
Binding site182-183substrate

GO annotations

AspectTerm
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Ordered locus names
      plu1177

Organism names

Accessions

  • Primary accession
    Q7N7H2

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001782061-197dITP/XTP pyrophosphatase

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    197
  • Mass (Da)
    21,163
  • Last updated
    2003-12-15 v1
  • Checksum
    609475040F2821A0
MQKVVLATGNPGKVRELAQLLADFGLDIVAQTELGVDSAEETGLTFIENAILKARHAAQVTGLPAIADDSGLSVDILGGAPGIYSARYAGENATDQQNLEKLLDTMKDIPDDQRQAQFNCVLVYIRHAEDPTPLVFHGRWPGFIAHKSAGNGGFGYDPIFYIPELGCTAAELTGEQKNAVSHRGQALKMMLDTLRNA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX571862
EMBL· GenBank· DDBJ
CAE13471.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp